Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/10656
Título
TAP-independent human histocompatibility complex-Cw1 antigen processing of an HIV envelope protein conserved peptide.
Autor(es)
Lorente, Elena ISCIII | Infantes, Susana ISCIII | Barnea, Eilon | Beer, Ilan | Garcia, Ruth ISCIII | Admon, Arie | Lasala, Fatima | Jimenez, Mercedes ISCIII | Lopez, Daniel ISCIII
Fecha de publicación
2011-01-14
Cita
AIDS . 2011 Jan 14;25(2):265-9.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Individuals with nonfunctional transporters associated with antigen processing (TAP) complexes are not particularly susceptible to viral infections or neoplasms. Therefore, their immune system must be reasonably efficient, and the present, though reduced, cytolytic CD8 αβ T subpopulation specific for TAP-independent antigens may be sufficient to establish an immune defense protecting against viral infections in these individuals. The objective of the present study was to identify TAP-independent ligands from HIV gp160 protein. An analysis and comparison of complex human histocompatibility complex (HLA)-bound peptide pools isolated from large quantities of healthy or HIV gp160-expressing human cells was performed using mass spectrometry and bioinformatics tools. A conserved TAP-independent HLA peptide ligand endogenously processed and presented in infected human cells was identified. This ligand originates from the envelope protein bound to the HLA-Cw1 class I molecule with high affinity. It was concluded that HLA class I peptides derived from a large fraction of the N-terminal HIV envelope protein could be presented even in the absence of the TAP complex.
MESH
ATP Binding Cassette Transporter, Subfamily B, Member 3 | ATP-Binding Cassette Transporters | HLA-C Antigens | Humans | Lymphocyte Activation | Major Histocompatibility Complex | Protein Binding | Viral Proteins
Versión en línea
DOI
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