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dc.contributor.authorPaulos, Silvia
dc.contributor.authorCardona, Guillermo A
dc.contributor.authorFernández-Crespo, Juan C
dc.contributor.authorStensvold, Christen R
dc.contributor.authorKöster, Pamela Carolina 
dc.contributor.authorLucio, Aida de 
dc.contributor.authorHernandez-De-Mingo, Marta 
dc.contributor.authorCarmena, David 
dc.date.accessioned2020-06-15T08:54:15Z
dc.date.available2020-06-15T08:54:15Z
dc.date.issued2018
dc.identifier.citationZoonoses Public Health . 2018 Dec;65(8):993-1002.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/10402
dc.description.abstractBlastocystis sp. is probably the most common enteric parasite in humans globally. Although the role of Blastocystis in human disease is still controversial, epidemiological and experimental evidence suggests that pathogenicity may be associated with certain subtypes of the protist. Since the life cycle of Blastocystis is maintained through still elusive pathways, companion animals have attracted the attention of researchers as potential reservoirs of human infections. In order to evaluate the risk of zoonotic transmission of Blastocystis, we investigated the occurrence and molecular diversity of this microorganism in human, canine and feline populations sharing temporal and spatial settings in the province of Álava, northern Spain. A total of 268 (including 179 human, 55 canine and 34 feline) faecal specimens were obtained from 63 family households during February-December 2014. Detection of Blastocystis was achieved by PCR amplification and sequencing of small subunit rRNA genes. Blastocystis was found in 35.2% (95% CI: 0.29%-0.42%) of the human stool samples analysed, but not in any of the canine or feline faecal specimens investigated. Out of the 63 PCR-positive human samples, 84.1% (53/63) were successfully subtyped, allowing the identification of the subtypes ST2 (62.3%), ST3 (17.0%), ST1 (13.2%) and ST4 (7.5%). No mixed subtype infections were identified. Blastocystis carriage was independent of the gender and region of origin of the affected individuals, but children in the age groups of >5-10 years and >10-15 years were significantly more affected by the protist. None of the risk factors considered (water-use practices, contact with livestock, contact with individual undergoing diarrhoeal episodes) were associated with increased prevalence of Blastocystis. Our data demonstrate that pet dogs and cats play a negligible role as natural reservoirs of human Blastocystis infection in this geographic region, although the applicability of these results should be corroborated in future molecular epidemiological studies.es_ES
dc.description.sponsorshipFunding Information: Health Institute Carlos III, Ministry of Economy and Competitiveness. Grant Number: CP12/03081es_ES
dc.language.isoenges_ES
dc.publisherWiley es_ES
dc.type.hasVersionAMes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAnimals es_ES
dc.subject.meshAnimals, Domestic es_ES
dc.subject.meshBlastocystis es_ES
dc.subject.meshBlastocystis Infections es_ES
dc.subject.meshCat Diseases es_ES
dc.subject.meshCats es_ES
dc.subject.meshDNA, Protozoan es_ES
dc.subject.meshDisease Reservoirs es_ES
dc.subject.meshDog Diseases es_ES
dc.subject.meshDogs es_ES
dc.subject.meshFamily Characteristics es_ES
dc.subject.meshFeces es_ES
dc.subject.meshGenetic Variation es_ES
dc.subject.meshHumans es_ES
dc.subject.meshPolymerase Chain Reaction es_ES
dc.subject.meshPrevalence es_ES
dc.subject.meshRisk Factors es_ES
dc.subject.meshSpain es_ES
dc.subject.meshZoonoses es_ES
dc.titleOccurrence and subtype distribution of Blastocystis sp. in humans, dogs and cats sharing household in northern Spain and assessment of zoonotic transmission risk.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID30198123es_ES
dc.format.volume65es_ES
dc.format.number8es_ES
dc.format.page993-1002es_ES
dc.identifier.doi10.1111/zph.12522es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderMinisterio de Economía y Competitividad (España) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1863-2378es_ES
dc.relation.publisherversionhttps://doi.org/10.1111/zph.12522es_ES
dc.identifier.journalZoonoses and public healthes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/CP12/03081es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución-NoComercial-CompartirIgual 4.0 Internacional