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dc.contributor.authorGalan, Iñaki 
dc.contributor.authorValencia-Martín, J L
dc.contributor.authorGuallar-Castillón, P
dc.contributor.authorRodríguez-Artalejo, Fernando
dc.date.accessioned2020-06-05T09:59:07Z
dc.date.available2020-06-05T09:59:07Z
dc.date.issued2014-02
dc.identifier.citationNutr Metab Cardiovasc Dis . 2014 Feb;24(2):189-97.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/10285
dc.description.abstractTo estimate the association between patterns of alcohol consumption and biomarkers of coronary heart disease (CHD) risk. Cross-sectional study among 10,793 individuals representative of the Spanish population aged ≥ 18 years. The threshold between moderate and heavy drinking was 40 g of alcohol/day in men and 24 g/day in women. Binge drinking was defined as intake of ≥ 80 g of alcohol in men and ≥ 60 g in women at any drinking occasion in the preceding 30 days. Analyses were performed with generalized linear models with adjustment for the main confounders, and results were expressed as the percentage change in the geometric mean (PCGM). Compared to non-drinkers, moderate and heavy drinkers had progressively higher serum HDL-cholesterol, with a PCGM ranging from 4.8% (95% CI: 3.7-6.0%) in moderate drinkers without binge drinking (MNB) to 9.6% (5.1-14.2%) in heavy drinkers with binge drinking (HB). Fibrinogen decreased progressively with alcohol intake, from -2.2% (-3.1 to -1.3%) in MNB to -5.8% (-9.4 to -2.0%) in HB. Leptin, glycated hemoglobin and the HOMA-index also decreased with increasing alcohol intake, and particularly with binge drinking. Moderate alcohol intake is associated with improved HDL-cholesterol, fibrinogen and markers of glucose metabolism, which is consistent with the reduced CHD risk of moderate drinkers in many studies. Heavy and binge drinking were also associated with favorable levels of CHD biomarkers; since these drinking patterns produce substantial health harms, our results should not be used to promote alcohol consumption.es_ES
dc.description.sponsorshipThis work was supported by Grant 06/2010 from the Plan Nacional sobre Drogas, Ministry of Health.es_ES
dc.language.isoenges_ES
dc.publisherElsevier es_ES
dc.type.hasVersionSMURes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshAdult es_ES
dc.subject.meshAged es_ES
dc.subject.meshAlcohol Drinking es_ES
dc.subject.meshAlcoholic Intoxication es_ES
dc.subject.meshBiomarkers es_ES
dc.subject.meshBlood Glucose es_ES
dc.subject.meshCholesterol, HDL es_ES
dc.subject.meshCoronary Disease es_ES
dc.subject.meshCross-Sectional Studies es_ES
dc.subject.meshFemale es_ES
dc.subject.meshFibrinogen es_ES
dc.subject.meshGlycated Hemoglobin A es_ES
dc.subject.meshHomeostasis es_ES
dc.subject.meshHumans es_ES
dc.subject.meshInsulin Resistance es_ES
dc.subject.meshLeptin es_ES
dc.subject.meshLinear Models es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshRisk Factors es_ES
dc.subject.meshSpain es_ES
dc.subject.meshYoung Adult es_ES
dc.titleAlcohol drinking patterns and biomarkers of coronary risk in the Spanish population.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID24418385es_ES
dc.format.volume24es_ES
dc.format.number2es_ES
dc.format.page189-97es_ES
dc.identifier.doi10.1016/j.numecd.2013.07.002es_ES
dc.contributor.funderMinisterio de Sanidad y Consumo (España) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1590-3729es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.numecd.2013.07.002es_ES
dc.identifier.journalNutrition, metabolism, and cardiovascular diseases : NMCDes_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/06/2010es_ES
dc.rights.accessRightsopen accesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 Internacional