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dc.contributor.authorDomingo-Relloso, Arce
dc.contributor.authorGrau-Perez, Maria
dc.contributor.authorGalan-Chilet, Inmaculada
dc.contributor.authorGarrido-Martinez, Maria J
dc.contributor.authorTormos, Carmen
dc.contributor.authorNavas-Acien, Ana
dc.contributor.authorGomez-Ariza, Jose L
dc.contributor.authorMonzo-Beltran, Lidia
dc.contributor.authorSaez-Tormo, Guillermo
dc.contributor.authorGarcia-Barrera, Tamara
dc.contributor.authorDueñas Laita, Antonio
dc.contributor.authorBriongos Figuero, Laisa S
dc.contributor.authorMartin-Escudero, Juan C
dc.contributor.authorChaves, F Javier
dc.contributor.authorRedon, Josep
dc.contributor.authorTellez-Plaza, Maria 
dc.date.accessioned2020-06-01T07:56:13Z
dc.date.available2020-06-01T07:56:13Z
dc.date.issued2019
dc.identifier.citationEnviron Int . 2019 Feb;123:171-180.es_ES
dc.identifier.issn0160-4120es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/10235
dc.description.abstractFew studies have investigated the role of exposure to metals and metal mixtures on oxidative stress in the general population. We evaluated the cross-sectional association of urinary metal and metal mixtures with urinary oxidative stress biomarkers, including oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8‑oxo‑7,8‑dihydroguanine (8-oxo-dG), in a representative sample of a general population from Spain (Hortega Study). Urine antimony (Sb), barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), molybdenum (Mo), vanadium (V) and zinc (Zn) were measured by ICPMS in 1440 Hortega Study participants. The geometric mean ratios (GMRs) of GSSG/GSH comparing the 80th to the 20th percentiles of metal distributions were 1.15 (95% confidence intervals [95% CI]: 1.03-1.27) for Mo, 1.17 (1.05-1.31) for Ba, 1.23 (1.04-1.46) for Cr and 1.18 (1.00-1.40) for V. For MDA, the corresponding GMRs (95% CI) were 1.13 (1.03-1.24) for Zn and 1.12 (1.02-1.23) for Cd. In 8-oxo-dG models, the corresponding GMR (95% CI) were 1.12 (1.01-1.23) for Zn and 1.09 (0.99-1.20) for Cd. Cr for GSSG/GSH and Zn for MDA and 8-oxo-dG drove most of the observed associations. Principal component (PC) 1 (largely reflecting non-essential metals) was positively associated with GSSG/GSH. The association of PC2 (largely reflecting essential metals) was positive for GSSG/GSH but inverse for MDA. Urine Ba, Cd, Cr, Mo, V and Zn were positively associated with oxidative stress measures at metal exposure levels relevant for the general population. The potential health consequences of environmental, including nutritional, exposure to these metals warrants further investigation.es_ES
dc.description.sponsorshipThis work was supported by the Strategic Action for Research in Health Sciences [CP12/03080, PI10/0082, PI13/01848, PI07/0497 and PI11/00726]; GRUPOS 03/101, PROMETEO/2009/029 and 2005/027, AMP07/075 and ACOMP/2013/039 from the Valencia Government; GRS/279/A/08 from Castilla-Leon Government; European Network of Excellence Ingenious Hypercare (EPSS-037093) from the European Commission; Retics (PREDIMED RD06/0045/0006); CIBER Fisiopatología Obesidad y Nutrición (CIBERobn) [CIBER-02-08-2009, CB06/03 and CB12/03/30016] and CIBER de Diabetes y Enfermedades Metabólicas Relacionadas (CIBERDEM CB07/0/018). The Strategic Action for Research in Health sciences, Retics, CIBEROBN and CIBERDEM are initiatives from Carlos III Health Institute Madrid and the Spanish Ministry of Economy and Competitiveness and co-funded with European Funds for Regional Development (FEDER). The authors declare they have no actual or potential competing financial interests.es_ES
dc.language.isoenges_ES
dc.publisherElsevier es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshOxidative Stress es_ES
dc.subject.mesh8-Hydroxy-2'-Deoxyguanosine es_ES
dc.subject.meshAdult es_ES
dc.subject.meshAged es_ES
dc.subject.meshBiomarkers es_ES
dc.subject.meshCross-Sectional Studies es_ES
dc.subject.meshDeoxyguanosine es_ES
dc.subject.meshEnvironmental Pollutants es_ES
dc.subject.meshFemale es_ES
dc.subject.meshGlutathione es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMale es_ES
dc.subject.meshMalondialdehyde es_ES
dc.subject.meshMetals, Heavy es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshSpain es_ES
dc.titleUrinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID30529889es_ES
dc.format.volume123es_ES
dc.format.page171-180es_ES
dc.identifier.doi10.1016/j.envint.2018.11.055es_ES
dc.contributor.funderGeneralitat Valenciana (España) 
dc.contributor.funderJunta de Castilla y León (España) 
dc.contributor.funderEuropean Network of Excellence EUROPRISE
dc.contributor.funderRedes Temáticas de Investigación Cooperativa en Salud (RETICS) (España) 
dc.contributor.funderCentro de Investigación Biomedica en Red - CIBER
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1873-6750es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.envint.2018.11.055es_ES
dc.identifier.journalEnvironment internationales_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/CP12/03080es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI10/0082es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI13/01848es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI07/0497es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI11/00726es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/GRUPOS 03/101es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PROMETEO/2009/029es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/2005/027es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/AMP07/07es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/ACOMP/2013/039es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/GRS/279/A/08es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/EPSS-037093es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PREDIMED RD06/0045/0006es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/CIBER-02-08-2009es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/CB06/03es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/CB12/03/30016es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/CB07/0/018es_ES
dc.rights.accessRightsopen accesses_ES


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