Systemic AL amyloidosis is a challenging disease for which many patients are considered frail in daily clinical practice. However, no study has so far addressed frailty and its impact on the outcome of these patients. We built a simple score to predict mortality based on three frailty-associated va...

Cardiovascular disease is the leading cause of death worldwide with myocardial infarction being the most prevalent. Currently, no cure is available to either prevent or revert the massive death of cardiomyocytes that occurs after a myocardial infarction. Adult mammalian hearts display a limited reg...

La Comisión Interministerial de Biomonitorización Humana (CIBMH) emana del Plan Estratégico de Salud y Medio Ambiente (PESMA), como una herramienta para la implementación de la biomonitorización humana (BMH) a nivel nacional, asegurando su integración con las estrategias europeas. La BMH tiene como...

Although cases of Legionnaires’ disease are notifiable, data on the phenotypic and genotypic characterisation of clinical isolates are limited. This retrospective study aims to report the results of the characterisation of Legionella clinical isolates in Spain from 2012 to 2022. Monoclonal antibodi...

El Instituto de Salud Carlos III (ISCIII) ha dado a conocer los proyectos ganadores de la tercera convocatoria de Investigación e Innovación Responsable (RRI) en Salud 2024, que tiene como objetivo reconocer, apoyar y fomentar el trabajo que realizan los Institutos de Investigación Sanitaria (IIS) ...

La intervención “Rutas Escolares Saludables” es el resultado de los procesos de co-creación y prototipado llevados a cabo en el Laboratorio ciudadano URBANMADLAB, creado en el marco del proyecto europeo H2020 URBANOME. El objetivo principal de la intervención es el de promover una mejora de la cali...

Legionellers' desease accounts for 1-8 % of cases of severe community-acquired pneumonia (CAP). Legionella spp. Is the causative organism that can result in respiratory failure, multi-organ dysfunction, sepsis, and death. Therefore, rapid diagnosis and efficient treatment are crucial. We report the...

Background: Cancer patients often have weakened immune systems, resulting in a lower response to vaccines, especially those receiving immunosuppressive oncological treatment (OT). We aimed to assess the impact of OT on the humoral and T-cell response to the B.1 lineage and Omicron variant following...

Alternative splicing of messenger RNA can generate an array of mature transcripts, but it is not clear how many go on to produce functionally relevant protein isoforms. There is only limited evidence for alternative proteins in proteomics analyses and data from population genetic variation studies ...