Now showing items 1-20 of 6681

    DNA methylation and cancer incidence: lymphatic-hematopoietic versus solid cancers in the Strong Heart Study. 

    Epigenetic alterations may contribute to early detection of cancer. We evaluated the association of blood DNA methylation with lymphatic-hematopoietic cancers and, for comparison, with solid cancers. We also evaluated the predictive ability of DNA methylation for lymphatic-hematopoietic cancers. B...

    Toll-Like Receptors in Acute Kidney Injury. 

    Acute kidney injury (AKI) is an important health problem, affecting 13.3 million individuals/year. It is associated with increased mortality, mainly in low- and middle-income countries, where renal replacement therapy is limited. Moreover, survivors show adverse long-term outcomes, including increa...

    Pneumococcal Choline-Binding Proteins Involved in Virulence as Vaccine Candidates. 

    Streptococcus pneumoniae is a pathogen responsible for millions of deaths worldwide. Currently, the available vaccines for the prevention of S. pneumoniae infections are the 23-valent pneumococcal polysaccharide-based vaccine (PPV-23) and the pneumococcal conjugate vaccines (PCV10 and PCV13). These...

    Population genomics of the pathogenic yeast Candida tropicalis identifies hybrid isolates in environmental samples. 

    Candida tropicalis is a human pathogen that primarily infects the immunocompromised. Whereas the genome of one isolate, C. tropicalis MYA-3404, was originally sequenced in 2009, there have been no large-scale, multi-isolate studies of the genetic and phenotypic diversity of this species. Here, we u...

    Senescent accelerated prone 8 (SAMP8) mice as a model of age dependent neuroinflammation 

    Aging and age-related diseases are strong risk factors for the development of neurodegenerative diseases. Neuroinflammation (NIF), as the brain's immune response, plays an important role in aged associated degeneration of central nervous system (CNS). There is a need for well characterized animal m...

    Low sensitivity of conventional fungal agars in fungemia by Rhodotorula mucilaginosa: description of two cases 

    Although most bloodstream yeast infections are caused by Candida spp., infections by rare or less common species have increased in recent years. Diagnosis of infections caused by these species is difficult due to the lack of specific symptoms and adequate diagnostic tools. We describe two cases of...

    Medicina y Seguridad del trabajo [246] 

    Número completo de : Medicina y seguridad del trabajo Vol.63 Nª 246 (2017)

    Trabajos de altura. Cuando un arnés sostiene la vida 

    [ES] Los datos de siniestralidad actuales revelan que el índice de incidencia de accidentes con baja en jornada de trabajo en el sector de la construcción ha disminuido significativamente en los últimos años. Sin embargo, este indicador sigue siendo más elevado que en el resto de sectores de prod...

    Exposición a pesticidas en el ámbito laboral, expresión genética y enfermedad de Parkinson 

    [ES] Introducción: Varias exposiciones ocupacionales pueden aumentar el riesgo de desarrollar la enfermedad de Parkinson. La exposición a pesticidas es un conocido factor de riesgo, pero no es suficiente para causar EP. Otros factores, como la susceptibilidad de diferentes variantes genéticas s...

    Obtaining EHR-derived datasets for COVID-19 research within a short time: a flexible methodology based on Detailed Clinical Models. 

    COVID-19 ranks as the single largest health incident worldwide in decades. In such a scenario, electronic health records (EHRs) should provide a timely response to healthcare needs and to data uses that go beyond direct medical care and are known as secondary uses, which include biomedical research...

    Recommendations from the European Commission Initiative on Breast Cancer for multigene testing to guide the use of adjuvant chemotherapy in patients with early breast cancer, hormone receptor positive, HER-2 negative. 

    Predicting the risk of recurrence and response to chemotherapy in women with early breast cancer is crucial to optimise adjuvant treatment. Despite the common practice of using multigene tests to predict recurrence, existing recommendations are inconsistent. Our aim was to formulate healthcare reco...

    Enfermedades actuales asociadas a los factores de riesgo laborales de la industria de la construcción en México 

    [ES] Resumen: La industria de la construcción es sin lugar a dudas una de las mayores generadoras de riesgos de trabajo, sin embargo, los programas de prevención no hacen evidente dicha situación. Los trabajadores de la industria de la construcción laboran bajo condiciones precarias, carecen de...

    Invisibilización del riesgo de accidente biológico en paramédicos de hospital de alta complejidad en Colombia 

    [ES] Objetivo: Comprender los significados y las prácticas del personal paramédico con relación al accidente biológico en un hospital de alta complejidad de la ciudad de Medellín-Colombia. Metodología: Desde un enfoque histórico hermenéutico utilizando herramientas de la teoría fundamentada, se ...

    Estrategia Iberoamericana de Seguridad y Salud en el Trabajo: políticas públicas para un trabajo decente 

    [ES] A través del presente artículo, se pretende realizar una revisión del marco institucional global y regional en materia de seguridad y salud en el trabajo con un enfoque de derechos humanos, cuyo eje central serán las estrategias adoptadas para la generación de políticas públicas, enfocadas en ...

    Nuevas aportaciones a la evaluación de la investigación: la declaración de San Francisco 

    [ES] Nuevas aportaciones a la evaluación de la investigación: la declaración de San Francisco [EN] New Contributions to the Evaluation of Research: the Statement of Saint Francis

    Retorno al trabajo tras cáncer de mama 

    [ES] El cáncer de mama frecuentemente es causa de largos procesos de baja. La duración media de las bajas por cáncer de mama es de unos 320 días, estando entre los tres procesos principales que causan bajas de más de 365 días junto con la lumbalgia y el trastorno ansioso depresivo. Cada año se prod...

    Occupational status and nutrition profile and health of public municipal employees 

    [EN] Background: Unhealthy lifestyles occur more often in low–socioeconomic status (SES) groups. The assessment of isolated factors reduces the understanding of the problem instead of clarifying the dynamic interaction of these factors in influencing the health.Objective: To study the relations...

    The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation. 

    Neuroblastoma is a highly metastatic tumor that emerges from neural crest cell progenitors. Focal Adhesion Kinase (FAK) is a regulator of cell migration that binds to the receptor Neogenin-1 and is upregulated in neuroblastoma. Here, we show that Netrin-1 ligand binding to Neogenin-1 leads to FAK a...

    Detection of asymptomatic Leishmania infection in Bangladesh by antibody and antigen diagnostic tools shows an association with post-kala-azar dermal leishmaniasis (PKDL) patients. 

    Asymptomatic Leishmania infections outnumber clinical infections on the Indian subcontinent (ISC), where disease reservoirs are anthroponotic. Diagnostics which detect active asymptomatic infection, which are suitable for monitoring and surveillance, may be of benefit to the visceral leishmaniasis ...

    Polyresistant Mycobacterium bovis Infection in Human and Sympatric Sheep, Spain, 2017-2018. 

    The main etiologic agent of tuberculosis (TB) in livestock is Mycobacterium bovis; human TB cases caused by M. bovis are rare. Analysis of a TB outbreak caused by polyresistant M. bovis involving a human and sympatric sheep in Spain suggests local circulation of drug-resistant M. bovis strains amon...