Now showing items 1-20 of 8322

    Early innate immune response triggered by the human respiratory syncytial virus and its regulation by ubiquitination/deubiquitination processes 

    The human respiratory syncytial virus (HRSV) causes severe lower respiratory tract infections in infants and the elderly. An exuberant inadequate immune response is behind most of the pathology caused by the HRSV. The main targets of HRSV infection are the epithelial cells of the respiratory tract,...

    Effect of the topical administration of corticosteroids and tuberculin pre-sensitisation on the diagnosis of tuberculosis in goats 

    Background: Caprine tuberculosis (TB) is a zoonosis caused by members of the Mycobacterium tuberculosis complex (MTBC). Caprine TB control and eradication programmes have traditionally been based on intradermal tuberculin tests and slaughterhouse surveillance. However, this strategy has limitations...

    Plasma miRNA profile at COVID-19 onset predicts severity status and mortality 

    Background: MicroRNAs (miRNAs) have a crucial role in regulating immune response against infectious diseases, showing changes early in disease onset and before the detection of the pathogen. Thus, we aimed to analyze the plasma miRNA profile at COVID-19 onset to identify miRNAs as early prognostic ...

    Cyst detection and viability assessment of Balantioides coli in environmental samples: Current status and future needs 

    The ciliate Balantioides coli is a human enteric parasite that can cause life-threatening infections. It is a food- and waterborne parasite, with cysts being the infective stage. Despite its importance as a potential pathogen, few reports have investigated its presence in environmental samples, and...

    Suicidal and accidental drug poisoning mortality among older adults and working-age individuals in Spain between 2000 and 2018 

    Background: Although medication poisoning in older adults is considered an increasingly important, but preventable cause of death, it has received relatively little attention. We explored recent trends and correlates of suicidal and accidental fatal drug poisonings among older and working-age indiv...

    Regional excess mortality during the 2020 COVID-19 pandemic in five European countries 

    The impact of the COVID-19 pandemic on excess mortality from all causes in 2020 varied across and within European countries. Using data for 2015-2019, we applied Bayesian spatio-temporal models to quantify the expected weekly deaths at the regional level had the pandemic not occurred in England, Gr...

    Healthy lifestyle, metabolomics and incident type 2 diabetes in a population-based cohort from Spain 

    Background: The contribution of metabolomic factors to the association of healthy lifestyle with type 2 diabetes risk is unknown. We assessed the association of a composite measure of lifestyle with plasma metabolite profiles and incident type 2 diabetes, and whether relevant metabolites can explai...

    Vigilancia centinela de Infección Respiratoria Aguda en Atención Primaria (IRAs) y en Hospitales (IRAG) Gripe, COVID-19 y otros virus respiratorios Semana 04/2022 (del 24 al 30 de enero 2022) Nº 65. 3 de febrero de 2022 

    En la semana 04/2022 la tasa global de IRAS se sitúa en 2.080 casos por 100.000 h, frente a 3.007 casos por 100.00 h la semana previa. Por grupos de edad, las mayores tasas de incidencia continúan observándose en los menores de 15 años (4.403 casos/100.000 h en el grupo de 0-4 años y 3.819 casos/10...

    Vigilancia centinela de Infección Respiratoria Aguda en Atención Primaria (IRAs) y en Hospitales (IRAG) Gripe, COVID-19 y otros virus respiratorios Semana 03/2022 (del 17 al 23 de enero 2022) Nº 64. 27 de enero de 2022 

    En la semana 03/2022 la tasa global de IRAS se sitúa en 1.832 casos por 100.000 h, frente a 1.967 casos por 100.00 h la semana previa. Por grupos de edad, las mayores tasas de incidencia continúan observándose en los menores de 15 años (3.748 casos/100.000 h en el grupo de 0-4 años). Esta semana se...

    Vigilancia centinela de Infección Respiratoria Aguda en Atención Primaria (IRAs) y en Hospitales (IRAG) Gripe, COVID-19 y otros virus respiratorios Semana 02/2022 (del 10 al 16 de enero 2022) Nº 63. 20 de enero de 2022 

    En la semana 02/2022 la tasa global de IRAS se sitúa en 1.613 casos por 100.000 h, similar a la de la semana previa. Por grupos de edad, las mayores tasas de incidencia se observan en los menores de 15 años (2.490 casos/100.000 h en el grupo de 5-14 años). Esta semana se han notificado 1.575 detecc...

    Vigilancia centinela de Infección Respiratoria Aguda en Atención Primaria (IRAs) y en Hospitales (IRAG) Gripe, COVID-19 y otros virus respiratorios Semana 01/2022 (del 3 al 9 de enero 2022) Nº 62. 13 de enero de 2022 

    En la semana 01/2022 la tasa global de IRAS se sitúa en 1.298 casos por 100.000 h. Por grupos de edad, esta semana, las mayores tasas de incidencia continúan observándose en el grupo de 15-44 años (1.566 casos/100.000 h). Esta semana se han notificado 1.298 detecciones de SARS-CoV-2 y una de virus ...

    Building a model of health technology assessment cooperation: lessons learned from EUnetHTA joint action 3 

    Objective: The European Network for Health Technology Assessment (EUnetHTA) was established in 2006. During its final project phase (joint action 3 [JA3]), it undertook an activity to define the scientific and technical principles of a model of health technology assessment (HTA) cooperation in Euro...

    Surveillance of leishmaniasis cases from 15 European centres, 2014 to 2019: a retrospective analysis 

    Background: Surveillance of human leishmaniasis in Europe is mostly limited to country-specific information from autochthonous infections in the southern part. As at the end of 2021, no integrated analysis has been performed for cases seen across centres in different European countries.AimTo provid...

    Semi-supervised incremental learning with few examples for discovering medical association rules 

    Background: Association Rules are one of the main ways to represent structural patterns underlying raw data. They represent dependencies between sets of observations contained in the data. The associations established by these rules are very useful in the medical domain, for example in the predicti...

    Predicted impact of the viral mutational landscape on the cytotoxic response against SARS-CoV-2 

    The massive assessment of immune evasion due to viral mutations that increase COVID-19 susceptibility can be computationally facilitated. The adaptive cytotoxic T response is critical during primary infection and the generation of long-term protection. Here, potential HLA class I epitopes in the SA...

    DBP rs7041 and DHCR7 rs3829251 are Linked to CD4+ Recovery in HIV Patients on Antiretroviral Therapy 

    Background: The lack of the recovery of CD4+ T-cells (CD4+ recovery) among immunodeficiency virus (HIV)-infected patients on antiretroviral therapy (ART) is not well known. We aimed to analyze the association between single nucleotide polymorphisms (SNPs) underlying vitamin D metabolism and the CD4...

    Health and economic impact of seasonal influenza mass vaccination strategies in European settings: A mathematical modelling and cost-effectiveness analysis 

    Introduction: Despite seasonal influenza vaccination programmes in most countries targeting individuals aged ≥ 65 (or ≥ 55) years and high risk-groups, significant disease burden remains. We explored the impact and cost-effectiveness of 27 vaccination programmes targeting the elderly and/or childre...

    Perimeter confinements of basic health zones and COVID-19 incidence in Madrid, Spain 

    Background: A unique policy of perimeter closures of Basic Health Zones (small administrative health units) was implemented in the Autonomous Community of Madrid from September 21st 2020 to May 23rd 2021 to face the COVID-19 pandemic. Aim: To assess the impact of local perimeter confinements on the...

    Impact of environmental and individual factors on COVID-19 mortality in children and adolescents in Mexico: An observational study 

    Background: During the Covid-19 pandemic, children and adolescents faced poverty, potentially dying from preventable causes, or missing out essential vaccines. The aim of this study was to assess potential environmental and individual factors associated to COVID-19 mortality in children and adolesc...

    Characterisation of tetraspanins from Schistosoma haematobium and evaluation of their potential as novel diagnostic markers 

    Schistosoma haematobium is the leading cause of urogenital schistosomiasis and it is recognised as a class 1 carcinogen due to the robust association of infection with bladder cancer. In schistosomes, tetraspanins (TSPs) are abundantly present in different parasite proteomes and could be potential ...