Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/9801
Título
The Neutrophil Life Cycle
Autor(es)
Fecha de publicación
2019-07
Cita
Trends Immunol. 2019; 40(7):584-597
Idioma
Inglés
Tipo de documento
journal article
Resumen
Neutrophils are recognized as an essential part of the innate immune response, but an active debate still exists regarding the life cycle of these cells. Neutrophils first differentiate in the bone marrow through progenitor intermediaries before entering the blood, in a process that gauges the extramedullary pool size. Once believed to be directly eliminated in the marrow, liver, and spleen, neutrophils, after circulating for less than 1 day, are now known to redistribute into multiple tissues with poorly understood kinetics. In this review, we provide an update on the dynamic distribution of neutrophils across tissues in health and disease, and emphasize differences between humans and model organisms. We further highlight issues to be addressed to exploit the unique features of neutrophils in the clinic.
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DOI
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