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dc.contributor.authorGomez-Moreno, Diego 
dc.contributor.authorAdrover, Jose M 
dc.contributor.authorHidalgo, Andrés
dc.identifier.citationEur J Clin Invest. 2018; 48(2):e12940es_ES
dc.description.abstractVascular inflammation underlies most forms of cardiovascular disease, which remains a prevalent cause of death among the global population. Advances in the biology of neutrophils, as well as insights into their dynamics in tissues, have revealed that these cells are prominent drivers of vascular inflammation though derailed activation within blood vessels. The development of powerful imaging techniques, as well as identification of cells and molecules that regulate their activation within vessels, including platelets and catecholamines, has been instrumental to better understand the mechanisms through which neutrophils protect or damage the organism. Other advances in our understanding of how these leucocytes exert detrimental functions on neighbouring cells, including the formation of DNA-based extracellular traps, constitute milestones in defining neutrophil-driven inflammation. Here, we review emerging mechanisms that regulate intravascular activation and effector functions of neutrophils, and discuss specific pathologies in which these processes are relevant. We argue that identification of pathways and mechanisms specifically engaged within the vasculature may provide effective therapies to treat this prevalent group of pathologies.es_ES
dc.description.sponsorshipWe wish to thank our funding sources: CIBERES for early funding and fellowship LACAIXA-SO16 to D.G-M., fellowship BES-2013–065550 to J.M.A.; grants SAF201565607-R and PCIN-2014-103 from Ministerio de Economia, Industria y Competitividad (MEIC), and co-funding by Fondo Europeo de Desarrollo Regional (FEDER) to A.H. The CNIC is supported by the MEIC and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (MEIC award SEV-2015-0505). The authors declare no conflicts of interest.es_ES
dc.subjectadrenergic signallinges_ES
dc.subjectcardiovascular diseasees_ES
dc.subjectneutrophil extracellular trapses_ES
dc.subjectvascular inflammationes_ES
dc.subject.meshAnemia, Sickle Cell es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshAtherosclerosis es_ES
dc.subject.meshBlood Platelets es_ES
dc.subject.meshDisease Models, Animales_ES
dc.subject.meshEndothelium, Vascular es_ES
dc.subject.meshExtracellular Traps es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMice es_ES
dc.subject.meshNeutrophil Infiltration es_ES
dc.subject.meshNeutrophils es_ES
dc.subject.meshReactive Oxygen Species es_ES
dc.subject.meshReperfusion Injury es_ES
dc.subject.meshSignal Transduction es_ES
dc.subject.meshVasculitis es_ES
dc.subject.meshVenous Thrombosis es_ES
dc.titleNeutrophils as effectors of vascular inflammationes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.format.volume48 Suppl 2es_ES
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España)es_ES
dc.contributor.funderCentro de Investigación Biomedica en Red - CIBERes_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderFundación ProCNICes_ES
dc.identifier.journalEuropean journal of clinical investigationes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmunees_ES

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional