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dc.contributor.author | Iborra, Salvador | |
dc.contributor.author | Izquierdo-Fernandez, Helena Maria | |
dc.contributor.author | Martinez-Lopez, Maria | |
dc.contributor.author | Blanco-Menendez, Noelia | |
dc.contributor.author | Reis e Sousa, Caetano | |
dc.contributor.author | Sancho, David | |
dc.date.accessioned | 2020-04-23T09:19:51Z | |
dc.date.available | 2020-04-23T09:19:51Z | |
dc.date.issued | 2012-05 | |
dc.identifier.citation | J Clin Invest. 2012; 122(5):1628-43 | es_ES |
dc.identifier.issn | 0021-9738 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/9713 | |
dc.description.abstract | In order to prime T cells, DCs integrate signals emanating directly from pathogens and from their noxious action on the host. DNGR-1 (CLEC9A) is a DC-restricted receptor that detects dead cells. Therefore, we investigated the possibility that DNGR-1 affects immunity to cytopathic viruses. DNGR-1 was essential for cross-presentation of dying vaccinia virus-infected (VACV-infected) cells to CD8(+) T cells in vitro. Following injection of VACV or VACV-infected cells into mice, DNGR-1 detected the ligand in dying infected cells and mediated cross-priming of anti-VACV CD8(+) T cells. Loss of DNGR-1 impaired the CD8+ cytotoxic response to VACV, especially against those virus strains that are most dependent on cross-presentation. The decrease in total anti-VACV CTL activity was associated with a profound increase in viral load and delayed resolution of the primary lesion. In addition, lack of DNGR-1 markedly diminished protection from infection induced by vaccination with the modified vaccinia Ankara (MVA) strain. DNGR-1 thus contributes to anti-VACV immunity, following both primary infection and vaccination. The non-redundant ability of DNGR-1 to regulate cross-presentation of viral antigens suggests that this form of regulation of antiviral immunity could be exploited for vaccination. | es_ES |
dc.description.sponsorship | Work in D. Sancho’s laboratory is funded by the CNIC and grants from the Spanish Ministry of Science and Innovation (SAF-2010-15120) and the European Research Council (ERC Starting Independent Researcher Grant 2010, ERC-2010-StG 260414). D. Sancho is the recipient of a Ramón y Cajal fellowship (RYC-2009-04235) from the Spanish Ministry of Science and Innovation. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society for Clinical Investigation (ASCI) | es_ES |
dc.type.hasVersion | AM | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Adaptive Immunity | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Antigen Presentation | es_ES |
dc.subject.mesh | Antigens, Viral | es_ES |
dc.subject.mesh | Apoptosis | es_ES |
dc.subject.mesh | CD8-Positive T-Lymphocytes | es_ES |
dc.subject.mesh | Cells, Cultured | es_ES |
dc.subject.mesh | Dendritic Cells | es_ES |
dc.subject.mesh | Gene Knockout Techniques | es_ES |
dc.subject.mesh | Interferon-gamma | es_ES |
dc.subject.mesh | Intracellular Signaling Peptides and Proteins | es_ES |
dc.subject.mesh | Lectins, C-Type | es_ES |
dc.subject.mesh | Lysosomes | es_ES |
dc.subject.mesh | Mice | es_ES |
dc.subject.mesh | Mice, Inbred C57BL | es_ES |
dc.subject.mesh | Mice, Transgenic | es_ES |
dc.subject.mesh | Necrosis | es_ES |
dc.subject.mesh | Protein-Tyrosine Kinases | es_ES |
dc.subject.mesh | Receptors, Immunologic | es_ES |
dc.subject.mesh | Syk Kinase | es_ES |
dc.subject.mesh | Vaccinia | es_ES |
dc.subject.mesh | Vaccinia virus | es_ES |
dc.subject.mesh | Viral Load | es_ES |
dc.subject.mesh | Cross-Priming | es_ES |
dc.title | The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 22505455 | es_ES |
dc.format.volume | 122 | es_ES |
dc.format.number | 5 | es_ES |
dc.format.page | 1628-43 | es_ES |
dc.identifier.doi | 10.1172/JCI60660 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1558-8238 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1172/JCI60660 | es_ES |
dc.identifier.journal | The Journal of clinical investigation | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Inmunobiología | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/260414 | es_ES |
dc.rights.accessRights | open access | es_ES |