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dc.contributor.author | Conejero, Laura | |
dc.contributor.author | Khouili, Sofia C. | |
dc.contributor.author | Martinez-Cano, Sarai | |
dc.contributor.author | Izquierdo-Fernandez, Helena Maria | |
dc.contributor.author | Brandi, Paola | |
dc.contributor.author | Sancho, David | |
dc.date.accessioned | 2020-04-23T08:15:13Z | |
dc.date.available | 2020-04-23T08:15:13Z | |
dc.date.issued | 2017-05-18 | |
dc.identifier.citation | JCI Insight. 2017; 2(10):90420 | es_ES |
dc.identifier.issn | 2379-3708 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/9705 | |
dc.description.abstract | DCs are necessary and sufficient for induction of allergic airway inflammation. CD11b+ DCs direct the underlying Th2 immunity, but debate surrounds the function of CD103+ DCs in lung immunity and asthma after an allergic challenge. We challenged Batf3-/- mice, which lacked lung CD103+ DCs, with the relevant allergen house dust mite (HDM) as a model to ascertain their role in asthma. We show that acute and chronic HDM exposure leads to defective Th1 immunity in Batf3-deficient mice. In addition, chronic HDM challenge in Batf3-/- mice results in increased Th2 and Th17 immune responses and exacerbated airway inflammation. Mechanistically, Batf3 absence does not affect induction of Treg or IL-10 production by lung CD4+ T cells following acute HDM challenge. Batf3-dependent CD103+ migratory DCs are the main source of IL-12p40 in the mediastinal lymph node DC compartment in the steady state. Moreover, CD103+ DCs selectively increase their IL-12p40 production upon HDM administration. In vivo IL-12 treatment reverts exacerbated allergic airway inflammation upon chronic HDM challenge in Batf3-/- mice, restraining Th2 and Th17 responses without triggering Th1 immunity. These results suggest a protective role for lung CD103+ DCs to HDM allergic airway inflammation through the production of IL-12. | es_ES |
dc.description.sponsorship | We are grateful to members of the DS lab for discussions and critical reading of the manuscript. We thank the staff at the CNIC facilities for technical support, Jesus Sanchez-Ruiz for the graphical illustration, Ruth Conde-Garrosa for technical assistance, Antonio Molina-Iracheta for histological quantification and analysis, and Simon Bartlett for editorial assistance. LC is the recipient of a European Respiratory Society Fellowship (RESPIRE2-2013-3708). Work in the DS laboratory is funded by the CNIC and grants from the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) and European Fund for Regional Development (FEDER) (SAF-2013-42920-R and SAF-2016-79040-R); the European Commission (635122-PROCROP H2020); and the Fondation ACTERIA. The CNIC is supported by the MEIC and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society for Clinical Investigation (ASCI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Immunology | es_ES |
dc.subject | Inflammation | es_ES |
dc.title | Lung CD103+ dendritic cells restrain allergic airway inflammation through IL-12 production | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 28515363 | es_ES |
dc.format.volume | 2 | es_ES |
dc.format.number | 10 | es_ES |
dc.format.page | 90420 | es_ES |
dc.identifier.doi | 10.1172/jci.insight.90420 | es_ES |
dc.contributor.funder | European Respiratory Society | |
dc.contributor.funder | Ministerio de Economía, Industria y Competitividad (España) | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Unión Europea. Comisión Europea | |
dc.contributor.funder | Fundación ProCNIC | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2379-3708 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1172/jci.insight.90420 | es_ES |
dc.identifier.journal | JCI insight | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Inmunobiología | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/635122 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF-2013-42920-R | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF-2016-79040-R | es_ES |
dc.rights.accessRights | open access | es_ES |