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dc.contributor.authorConejero, Laura 
dc.contributor.authorKhouili, Sofia C. 
dc.contributor.authorMartinez-Cano, Sarai 
dc.contributor.authorIzquierdo-Fernandez, Helena Maria 
dc.contributor.authorBrandi, Paola 
dc.contributor.authorSancho, David 
dc.date.accessioned2020-04-23T08:15:13Z
dc.date.available2020-04-23T08:15:13Z
dc.date.issued2017-05-18
dc.identifier.citationJCI Insight. 2017; 2(10):90420es_ES
dc.identifier.issn2379-3708es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9705
dc.description.abstractDCs are necessary and sufficient for induction of allergic airway inflammation. CD11b+ DCs direct the underlying Th2 immunity, but debate surrounds the function of CD103+ DCs in lung immunity and asthma after an allergic challenge. We challenged Batf3-/- mice, which lacked lung CD103+ DCs, with the relevant allergen house dust mite (HDM) as a model to ascertain their role in asthma. We show that acute and chronic HDM exposure leads to defective Th1 immunity in Batf3-deficient mice. In addition, chronic HDM challenge in Batf3-/- mice results in increased Th2 and Th17 immune responses and exacerbated airway inflammation. Mechanistically, Batf3 absence does not affect induction of Treg or IL-10 production by lung CD4+ T cells following acute HDM challenge. Batf3-dependent CD103+ migratory DCs are the main source of IL-12p40 in the mediastinal lymph node DC compartment in the steady state. Moreover, CD103+ DCs selectively increase their IL-12p40 production upon HDM administration. In vivo IL-12 treatment reverts exacerbated allergic airway inflammation upon chronic HDM challenge in Batf3-/- mice, restraining Th2 and Th17 responses without triggering Th1 immunity. These results suggest a protective role for lung CD103+ DCs to HDM allergic airway inflammation through the production of IL-12.es_ES
dc.description.sponsorshipWe are grateful to members of the DS lab for discussions and critical reading of the manuscript. We thank the staff at the CNIC facilities for technical support, Jesus Sanchez-Ruiz for the graphical illustration, Ruth Conde-Garrosa for technical assistance, Antonio Molina-Iracheta for histological quantification and analysis, and Simon Bartlett for editorial assistance. LC is the recipient of a European Respiratory Society Fellowship (RESPIRE2-2013-3708). Work in the DS laboratory is funded by the CNIC and grants from the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) and European Fund for Regional Development (FEDER) (SAF-2013-42920-R and SAF-2016-79040-R); the European Commission (635122-PROCROP H2020); and the Fondation ACTERIA. The CNIC is supported by the MEIC and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505).es_ES
dc.language.isoenges_ES
dc.publisherAmerican Society for Clinical Investigation (ASCI) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectImmunologyes_ES
dc.subjectInflammationes_ES
dc.titleLung CD103+ dendritic cells restrain allergic airway inflammation through IL-12 productiones_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID28515363es_ES
dc.format.volume2es_ES
dc.format.number10es_ES
dc.format.page90420es_ES
dc.identifier.doi10.1172/jci.insight.90420es_ES
dc.contributor.funderEuropean Respiratory Society 
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España) 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.contributor.funderUnión Europea. Comisión Europea 
dc.contributor.funderFundación ProCNIC 
dc.description.peerreviewedes_ES
dc.identifier.e-issn2379-3708es_ES
dc.relation.publisherversionhttps://doi.org/10.1172/jci.insight.90420es_ES
dc.identifier.journalJCI insightes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Inmunobiologíaes_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/635122es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF-2013-42920-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF-2016-79040-Res_ES
dc.rights.accessRightsopen accesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 Internacional