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dc.contributor.authorWculek, Stefanie K 
dc.contributor.authorCueto, Francisco J. 
dc.contributor.authorMujal, Adriana M
dc.contributor.authorMelero, Ignacio
dc.contributor.authorKrummel, Matthew F
dc.contributor.authorSancho, David 
dc.date.accessioned2020-04-20T07:14:23Z
dc.date.available2020-04-20T07:14:23Z
dc.date.issued2020-01
dc.identifier.citationNat Rev Immunol. 2020; 20(1):7-24es_ES
dc.identifier.issn1474-1733es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9618
dc.description.abstractDendritic cells (DCs) are a diverse group of specialized antigen-presenting cells with key roles in the initiation and regulation of innate and adaptive immune responses. As such, there is currently much interest in modulating DC function to improve cancer immunotherapy. Many strategies have been developed to target DCs in cancer, such as the administration of antigens with immunomodulators that mobilize and activate endogenous DCs, as well as the generation of DC-based vaccines. A better understanding of the diversity and functions of DC subsets and of how these are shaped by the tumour microenvironment could lead to improved therapies for cancer. Here we will outline how different DC subsets influence immunity and tolerance in cancer settings and discuss the implications for both established cancer treatments and novel immunotherapy strategies.es_ES
dc.description.sponsorshipS.K.W. is supported by a European Molecular Biology Organization Long- Term Fellowship (grant ALTF 438– 2016) and a CNIC–International Postdoctoral Program Fellowship (grant 17230–2016). F.J.C. is the recipient of a PhD ‘La Caixa’ fellowship. Work in the D.S. laboratory is funded by the CNIC, by the European Research Council (ERC Consolidator Grant 2016 725091), by the European Commission (635122-PROCROP H2020), by the Ministerio de Ciencia, Innovación e Universidades (MCNU), Agencia Estatal de Investigación and Fondo Europeo de Desarrollo Regional (FEDER) (SAF2016-79040-R), by the Comunidad de Madrid (B2017/BMD-3733 Immunothercan- CM), by FIS- Instituto de Salud Carlos III, MCNU and FEDER (RD16/0015/0018-REEM), by Acteria Foundation, by Atresmedia (Constantes y Vitales prize) and by Fundació La Marató de TV3 (201723). The CNIC is supported by the Instituto de Salud Carlos III, the MCNU and the Pro CNIC Foundation, and is a Severo Ochoa Centre of Excellence (SEV-2015-0505).es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Group es_ES
dc.type.hasVersionAMes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleDendritic cells in cancer immunology and immunotherapyes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID31467405es_ES
dc.format.volume20es_ES
dc.format.number1es_ES
dc.format.page7-24es_ES
dc.identifier.doi10.1038/s41577-019-0210-zes_ES
dc.contributor.funderEuropean Molecular Biology Organization 
dc.contributor.funderFundación La Caixa 
dc.contributor.funderUnión Europea. Comisión Europea 
dc.contributor.funderUnión Europea. Comisión Europea. European Research Council (ERC) 
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España) 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.contributor.funderComunidad de Madrid (España) 
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderFondation ACTERIA (Acting on European Research in Immunology and Allergology) 
dc.contributor.funderAtresmedia 
dc.contributor.funderFundación La Marató TV3 
dc.contributor.funderFundación ProCNIC 
dc.description.peerreviewedes_ES
dc.embargo.terms2020-07-01es_ES
dc.identifier.e-issn1474-1741es_ES
dc.relation.publisherversionhttps://doi.org/10.1038/s41577-019-0210-zes_ES
dc.identifier.journalNature reviews. Immunologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Inmunobiologíaes_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/725091es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/635122es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2016-79040-Res_ES
dc.rights.accessRightsopen accesses_ES


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