Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/9332
Título
Cripto shapes macrophage plasticity and restricts EndMT in injured and diseased skeletal muscle
Autor(es)
Fecha de publicación
2020-02-27
Cita
EMBO Rep. 2020:e49075
Idioma
Inglés
Tipo de documento
journal article
Resumen
Macrophages are characterized by a high plasticity in response to changes in tissue microenvironment, which allows them to acquire different phenotypes and to exert essential functions in complex processes, such as tissue regeneration. Here, we report that the membrane protein Cripto plays a key role in shaping macrophage plasticity in skeletal muscle during regeneration and disease. Conditional deletion of Cripto in the myeloid lineage (CriptoMy-LOF ) perturbs MP plasticity in acutely injured muscle and in mouse models of Duchenne muscular dystrophy (mdx). Specifically, CriptoMy-LOF macrophages infiltrate the muscle, but fail to properly expand as anti-inflammatory CD206+ macrophages, which is due, at least in part, to aberrant activation of TGFβ/Smad signaling. This reduction in macrophage plasticity disturbs vascular remodeling by increasing Endothelial-to-Mesenchymal Transition (EndMT), reduces muscle regenerative potential, and leads to an exacerbation of the dystrophic phenotype. Thus, in muscle-infiltrating macrophages, Cripto is required to promote the expansion of the CD206+ anti-inflammatory macrophage type and to restrict the EndMT process, providing a direct functional link between this macrophage population and endothelial cells.
Palabras clave
Cripto | Duchenne muscular dystrophy | Endothelial-to-Mesenchymal Transition | Macrophage plasticity | Skeletal muscle regeneration
Versión en línea
DOI
Aparece en las colecciones
Ficheros en el ítem
![Acceso Abierto Acceso Abierto](/themes/Mirage2/images/openAccess.png)
- Nombre:
- CriptoShapesMacrophagePlastici ...
- Tamaño:
- 18.39Mb
- Formato:
- Descripción:
- Artículo
![Acceso Abierto Acceso Abierto](/themes/Mirage2/images/openAccess.png)
- Nombre:
- CriptoShapesMacrophagePlastici ...
- Tamaño:
- 4.120Mb
- Formato:
- Microsoft Excel 2007