dc.contributor.author | Velasco, Carlos | |
dc.contributor.author | Mota-Cobian, Adriana | |
dc.contributor.author | Mateo, Jesus | |
dc.contributor.author | Espana, Samuel | |
dc.date.accessioned | 2020-01-29T08:42:14Z | |
dc.date.available | 2020-01-29T08:42:14Z | |
dc.date.issued | 2019-12-16 | |
dc.identifier.citation | EJNMMI Phys. 2019; 6(1):25 | es_ES |
dc.identifier.issn | 2197-7364 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/8928 | |
dc.description.abstract | BACKGROUND: Multi-tracer positron emission tomography (PET) imaging can be accomplished by applying multi-tracer compartment modeling. Recently, a method has been proposed in which the arterial input functions (AIFs) of the multi-tracer PET scan are explicitly derived. For that purpose, a gamma spectroscopic analysis is performed on blood samples manually withdrawn from the patient when at least one of the co-injected tracers is based on a non-pure positron emitter. Alternatively, these blood samples required for the spectroscopic analysis may be obtained and analyzed on site by an automated detection device, thus minimizing analysis time and radiation exposure of the operating personnel. In this work, a new automated blood sample detector based on silicon photomultipliers (SiPMs) for single- and multi-tracer PET imaging is presented, characterized, and tested in vitro and in vivo. RESULTS: The detector presented in this work stores and analyzes on-the-fly single and coincidence detected events. A sensitivity of 22.6 cps/(kBq/mL) and 1.7 cps/(kBq/mL) was obtained for single and coincidence events respectively. An energy resolution of 35% full-width-half-maximum (FWHM) at 511 keV and a minimum detectable activity of 0.30 ± 0.08 kBq/mL in single mode were obtained. The in vivo AIFs obtained with the detector show an excellent Pearson's correlation (r = 0.996, p < 0.0001) with the ones obtained from well counter analysis of discrete blood samples. Moreover, in vitro experiments demonstrate the capability of the detector to apply the gamma spectroscopic analysis on a mixture of 68Ga and 18F and separate the individual signal emitted from each one. CONCLUSIONS: Characterization and in vivo evaluation under realistic experimental conditions showed that the detector proposed in this work offers excellent sensibility and stability. The device also showed to successfully separate individual signals emitted from a mixture of radioisotopes. Therefore, the blood sample detector presented in this study allows fully automatic AIFs measurements during single- and multi-tracer PET studies. | es_ES |
dc.description.sponsorship | This work was supported by grants from the Carlos III Institute of Health of Spain and Fondo Europeo de Desarrollo Regional (FEDER, “Una manera de hacer Europa”) (FIS-FEDER PI14-01427), and from the Comunidad de Madrid (2016-T1/TIC-1099). CV holds a fellowship from the Spanish Ministry of Education (FPU014/01794). The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia, Innovación y Universidades (MCNU), and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Arterial input function | es_ES |
dc.subject | Blood activity | es_ES |
dc.subject | Blood sample detector | es_ES |
dc.subject | Gamma spectroscopy | es_ES |
dc.subject | Multi-tracer PET | es_ES |
dc.subject | Non-pure beta emitter | es_ES |
dc.subject | Pharmacokinetic modeling | es_ES |
dc.subject | Positron emission tomography | es_ES |
dc.subject | Silicon photomultiplier | es_ES |
dc.title | Development of a blood sample detector for multi-tracer positron emission tomography using gamma spectroscopy | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 31845002 | es_ES |
dc.format.volume | 6 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 25 | es_ES |
dc.identifier.doi | 10.1186/s40658-019-0263-x | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.contributor.funder | Ministerio de Educación (España) | |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | |
dc.contributor.funder | Fundación ProCNIC | |
dc.relation.publisherversion | https://doi.org/10.1186/s40658-019-0263-x | es_ES |
dc.identifier.journal | EJNMMI physics | es_ES |
dc.repisalud.orgCNIC | CNIC::Unidades técnicas | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III/null/null/Subprograma de proyectos de investigacion en salud (AES 2014). Modalidad proyectos en salud. (2014)/PI14/01427 | |