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dc.contributor.author | Herrero-Fernandez, Beatriz | |
dc.contributor.author | Gomez-Bris, Raquel | |
dc.contributor.author | Somovilla-Crespo, Beatriz | |
dc.contributor.author | Gonzalez-Granado, Jose Maria | |
dc.date.accessioned | 2019-10-31T10:49:53Z | |
dc.date.available | 2019-10-31T10:49:53Z | |
dc.date.issued | 2019-10 | |
dc.identifier.citation | Int J Mol Sci. 2019; 20(21):e5293 | es_ES |
dc.identifier.issn | 1422-0067 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/8540 | |
dc.description.abstract | Cardiovascular disease is the leading cause of mortality worldwide, and atherosclerosis the principal factor underlying cardiovascular events. Atherosclerosis is a chronic inflammatory disease characterized by endothelial dysfunction, intimal lipid deposition, smooth muscle cell proliferation, cell apoptosis and necrosis, and local and systemic inflammation, involving key contributions to from innate and adaptive immunity. The balance between proatherogenic inflammatory and atheroprotective anti-inflammatory responses is modulated by a complex network of interactions among vascular components and immune cells, including monocytes, macrophages, dendritic cells, and T, B, and foam cells; these interactions modulate the further progression and stability of the atherosclerotic lesion. In this review, we take a global perspective on existing knowledge about the pathogenesis of immune responses in the atherosclerotic microenvironment and the interplay between the major innate and adaptive immune factors in atherosclerosis. Studies such as this are the basis for the development of new therapies against atherosclerosis. | es_ES |
dc.description.sponsorship | The authors’ research is supported by grants from the Instituto de Salud Carlos III (ISCIII) (PI17/01395; CPII16/00022) and EuroCellNet COST Action CA15214 with co-funding from the European Regional Development Fund (ERDF), “A way to build Europe,” and the Miguel Servet Program. The CNIC is supported by the ISCIII, the Ministerio de Ciencia, Innovación y Universidades (MCNU), and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505). J.M.G.-G. is supported by the ISCIII Miguel Servet Program, i+12 and Universidad Autónoma de Madrid (UAM); R.G.B. and B.S. by i+12 and ISCIII and B.H.F. by i+12, UAM and FPU programs from the MCNU. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | B-cell | es_ES |
dc.subject | T-cell | es_ES |
dc.subject | Atherosclerosis | es_ES |
dc.subject | Conventional dendritic cell | es_ES |
dc.subject | Foam cell | es_ES |
dc.subject | Macrophage | es_ES |
dc.subject | Monocyte | es_ES |
dc.subject | Monocyte-derived dendritic cell | es_ES |
dc.subject | Plasmacytoid dendritic cell | es_ES |
dc.subject | Regulatory dendritic cell | es_ES |
dc.title | Immunobiology of Atherosclerosis: A Complex Net of Interactions | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 31653058 | es_ES |
dc.format.volume | 20 | es_ES |
dc.format.number | 21 | es_ES |
dc.format.page | 5293 | es_ES |
dc.identifier.doi | 10.3390/ijms20215293 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | |
dc.contributor.funder | Fundación ProCNIC | |
dc.contributor.funder | Autonomous University of Madrid (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1422-0067 | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/ijms20215293 | es_ES |
dc.identifier.journal | International journal of molecular sciences | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Comunicación Intercelular en la Respuesta Inflamatoria | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Fisiopatología Cardiovascular Molecular y Genética | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI17/01395 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/CPII16/00022 | es_ES |
dc.rights.accessRights | open access | es_ES |