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dc.contributor.author | Murphy, Aoife M | |
dc.contributor.author | Smith, Caren E | |
dc.contributor.author | Murphy, Leanne M | |
dc.contributor.author | Follis, Jack L | |
dc.contributor.author | Tanaka, Toshiko | |
dc.contributor.author | Richardson, Kris | |
dc.contributor.author | Noordam, Raymond | |
dc.contributor.author | Lemaitre, Rozenn N | |
dc.contributor.author | Kähönen, Mika | |
dc.contributor.author | Dupuis, Josée | |
dc.contributor.author | Voortman, Trudy | |
dc.contributor.author | Marouli, Eirini | |
dc.contributor.author | Mook-Kanamori, Dennis O | |
dc.contributor.author | Raitakari, Olli T | |
dc.contributor.author | Hong, Jaeyoung | |
dc.contributor.author | Dehghan, Abbas | |
dc.contributor.author | Dedoussis, George | |
dc.contributor.author | de Mutsert, Renée | |
dc.contributor.author | Lehtimäki, Terho | |
dc.contributor.author | Liu, Ching-Ti | |
dc.contributor.author | Rivadeneira, Fernando | |
dc.contributor.author | Deloukas, Panagiotis | |
dc.contributor.author | Mikkilä, Vera | |
dc.contributor.author | Meigs, James B | |
dc.contributor.author | Uitterlinden, Andre | |
dc.contributor.author | Ikram, Mohammad A | |
dc.contributor.author | Franco, Oscar H | |
dc.contributor.author | Hughes, Maria | |
dc.contributor.author | O' Gaora, Peadar | |
dc.contributor.author | Ordovas, Jose M | |
dc.contributor.author | Roche, Helen M | |
dc.date.accessioned | 2019-10-17T08:40:20Z | |
dc.date.available | 2019-10-17T08:40:20Z | |
dc.date.issued | 2019-08-20 | |
dc.identifier.citation | Mol Nutr Food Res. 2019: e1900226 | es_ES |
dc.identifier.issn | 1613-4125 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/8505 | |
dc.description.abstract | SCOPE: Insulin resistance (IR) and inflammation are hallmarks of type 2 diabetes (T2D). The nod-like receptor pyrin domain containing-3 (NLRP3) inflammasome is a metabolic sensor activated by saturated fatty acids (SFA) initiating IL-1β inflammation and IR. Interactions between SFA intake and NLRP3-related genetic variants may alter T2D risk factors. METHODS: Meta-analyses of six Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (n = 19 005) tested interactions between SFA and NLRP3-related single-nucleotide polymorphisms (SNPs) and modulation of fasting insulin, fasting glucose, and homeostasis model assessment of insulin resistance. RESULTS: SFA interacted with rs12143966, wherein each 1% increase in SFA intake increased insulin by 0.0063 IU mL-1 (SE ± 0.002, p = 0.001) per each major (G) allele copy. rs4925663, interacted with SFA (β ± SE = -0.0058 ± 0.002, p = 0.004) to increase insulin by 0.0058 IU mL-1 , per additional copy of the major (C) allele. Both associations are close to the significance threshold (p < 0.0001). rs4925663 causes a missense mutation affecting NLRP3 expression. CONCLUSION: Two NLRP3-related SNPs showed potential interaction with SFA to modulate fasting insulin. Greater dietary SFA intake accentuates T2D risk, which, subject to functional validation, may be further elaborated depending on NLRP3-related genetic variants. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | Cohorts for Heart and Ageing Research in Genomic Epidemiology consortium | es_ES |
dc.subject | NLRP3 inflammasomes | es_ES |
dc.subject | Genome-wide interaction studies | es_ES |
dc.subject | Insulin resistance | es_ES |
dc.subject | Meta-analyses | es_ES |
dc.subject | Saturated fats | es_ES |
dc.title | Potential Interplay between Dietary Saturated Fats and Genetic Variants of the NLRP3 Inflammasome to Modulate Insulin Resistance and Diabetes Risk: Insights from a Meta-Analysis of 19 005 Individuals | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-NoComercial 4.0 Internacional | * |
dc.identifier.pubmedID | 31432628 | es_ES |
dc.format.page | e1900226 | es_ES |
dc.identifier.doi | 10.1002/mnfr.201900226 | es_ES |
dc.contributor.funder | Science Foundation Ireland | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1613-4133 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1002/mnfr.201900226 | es_ES |
dc.identifier.journal | Molecular nutrition & food research | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionales | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |