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dc.contributor.authorHamdi, Yosr
dc.contributor.authorSoucy, Penny
dc.contributor.authorKuchenbaeker, Karoline B
dc.contributor.authorPastinen, Tomi
dc.contributor.authorDroit, Arnaud
dc.contributor.authorLemaçon, Audrey
dc.contributor.authorAdlard, Julian
dc.contributor.authorAittomäki, Kristiina
dc.contributor.authorAndrulis, Irene L
dc.contributor.authorArason, Adalgeir
dc.contributor.authorArnold, Norbert
dc.contributor.authorArun, Banu K
dc.contributor.authorAzzollini, Jacopo
dc.contributor.authorBane, Anita
dc.contributor.authorBarjhoux, Laure
dc.contributor.authorBarrowdale, Daniel
dc.contributor.authorBenitez, Javier 
dc.contributor.authorBerthet, Pascaline
dc.contributor.authorBlok, Marinus J
dc.contributor.authorBobolis, Kristie
dc.contributor.authorBonadona, Valérie
dc.contributor.authorBonanni, Bernardo
dc.contributor.authorBradbury, Angela R
dc.contributor.authorBrewer, Carole
dc.contributor.authorBuecher, Bruno
dc.contributor.authorBuys, Saundra S
dc.contributor.authorCaligo, Maria A
dc.contributor.authorChiquette, Jocelyne
dc.contributor.authorChung, Wendy K
dc.contributor.authorClaes, Kathleen B M
dc.contributor.authorDaly, Mary B
dc.contributor.authorDamiola, Francesca
dc.contributor.authorDavidson, Rosemarie
dc.contributor.authorDe la Hoya, Miguel
dc.contributor.authorDe Leeneer, Kim
dc.contributor.authorDiez, Orland
dc.contributor.authorDing, Yuan Chun
dc.contributor.authorDolcetti, Riccardo
dc.contributor.authorDomchek, Susan M
dc.contributor.authorDorfling, Cecilia M
dc.contributor.authorEccles, Diana
dc.contributor.authorEeles, Ros
dc.contributor.authorEinbeigi, Zakaria
dc.contributor.authorEjlertsen, Bent
dc.contributor.authorEngel, Christoph
dc.contributor.authorGareth Evans, D
dc.contributor.authorFeliubadalo, Lidia
dc.contributor.authorForetova, Lenka
dc.contributor.authorFostira, Florentia
dc.contributor.authorFoulkes, William D
dc.contributor.authorFountzilas, George
dc.contributor.authorFriedman, Eitan
dc.contributor.authorFrost, Debra
dc.contributor.authorGanschow, Pamela
dc.contributor.authorGanz, Patricia A
dc.contributor.authorGarber, Judy
dc.contributor.authorGayther, Simon A
dc.contributor.authorGerdes, Anne-Marie
dc.contributor.authorGlendon, Gord
dc.contributor.authorGodwin, Andrew K
dc.contributor.authorGoldgar, David E
dc.contributor.authorGreene, Mark H
dc.contributor.authorGronwald, Jacek
dc.contributor.authorHahnen, Eric
dc.contributor.authorHamann, Ute
dc.contributor.authorHansen, Thomas V O
dc.contributor.authorHart, Steven
dc.contributor.authorHays, John L
dc.contributor.authorHogervorst, Frans B L
dc.contributor.authorHulick, Peter J
dc.contributor.authorImyanitov, Evgeny N
dc.contributor.authorIsaacs, Claudine
dc.contributor.authorIzatt, Louise
dc.contributor.authorJakubowska, Anna
dc.contributor.authorJames, Paul
dc.contributor.authorJanavicius, Ramunas
dc.contributor.authorJensen, Uffe Birk
dc.contributor.authorJohn, Esther M
dc.contributor.authorJoseph, Vijai
dc.contributor.authorJust, Walter
dc.contributor.authorKaczmarek, Katarzyna
dc.contributor.authorKarlan, Beth Y
dc.contributor.authorKets, Carolien M
dc.contributor.authorKirk, Judy
dc.contributor.authorKriege, Mieke
dc.contributor.authorLaitman, Yael
dc.contributor.authorLaurent, Maïté
dc.contributor.authorLazaro, Conxi
dc.contributor.authorLeslie, Goska
dc.contributor.authorLester, Jenny
dc.contributor.authorLesueur, Fabienne
dc.contributor.authorLiljegren, Annelie
dc.contributor.authorLoman, Niklas
dc.contributor.authorLoud, Jennifer T
dc.contributor.authorManoukian, Siranoush
dc.contributor.authorMariani, Milena
dc.contributor.authorMazoyer, Sylvie
dc.contributor.authorMcGuffog, Lesley
dc.contributor.authorMeijers-Heijboer, Hanne E J
dc.contributor.authorMeindl, Alfons
dc.contributor.authorMiller, Austin
dc.contributor.authorMontagna, Marco
dc.contributor.authorMulligan, Anna Marie
dc.contributor.authorNathanson, Katherine L
dc.contributor.authorNeuhausen, Susan L
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorNussbaum, Robert L
dc.contributor.authorOlah, Edith
dc.contributor.authorOlopade, Olufunmilayo I
dc.contributor.authorOng, Kai-Ren
dc.contributor.authorOosterwijk, Jan C
dc.contributor.authorOsorio, Ana 
dc.contributor.authorPapi, Laura
dc.contributor.authorPark, Sue Kyung
dc.contributor.authorPedersen, Inge Sokilde
dc.contributor.authorPeissel, Bernard
dc.contributor.authorSegura, Pedro Perez
dc.contributor.authorPeterlongo, Paolo
dc.contributor.authorPhelan, Catherine M
dc.contributor.authorRadice, Paolo
dc.contributor.authorRantala, Johanna
dc.contributor.authorRappaport-Fuerhauser, Christine
dc.contributor.authorRennert, Gad
dc.contributor.authorRichardson, Andrea
dc.contributor.authorRobson, Mark
dc.contributor.authorRodriguez, Gustavo C
dc.contributor.authorRookus, Matti A
dc.contributor.authorSchmutzler, Rita Katharina
dc.contributor.authorSevenet, Nicolas
dc.contributor.authorShah, Payal D
dc.contributor.authorSinger, Christian F
dc.contributor.authorSlavin, Thomas P
dc.contributor.authorSnape, Katie
dc.contributor.authorSokolowska, Johanna
dc.contributor.authorSønderstrup, Ida Marie Heeholm
dc.contributor.authorSouthey, Melissa
dc.contributor.authorSpurdle, Amanda B
dc.contributor.authorStadler, Zsofia
dc.contributor.authorStoppa-Lyonnet, Dominique
dc.contributor.authorSukiennicki, Grzegorz
dc.contributor.authorSutter, Christian
dc.contributor.authorTan, Yen
dc.contributor.authorTea, Muy-Kheng
dc.contributor.authorTeixeira, Manuel R
dc.contributor.authorTeulé, Alex
dc.contributor.authorTeo, Soo-Hwang
dc.contributor.authorTerry, Mary Beth
dc.contributor.authorThomassen, Mads
dc.contributor.authorTihomirova, Laima
dc.contributor.authorTischkowitz, Marc
dc.contributor.authorTognazzo, Silvia
dc.contributor.authorToland, Amanda Ewart
dc.contributor.authorTung, Nadine
dc.contributor.authorvan den Ouweland, Ans M W
dc.contributor.authorvan der Luijt, Rob B
dc.contributor.authorvan Engelen, Klaartje
dc.contributor.authorvan Rensburg, Elizabeth J
dc.contributor.authorVaron-Mateeva, Raymonda
dc.contributor.authorWappenschmidt, Barbara
dc.contributor.authorWijnen, Juul T
dc.contributor.authorRebbeck, Timothy
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorOffit, Kenneth
dc.contributor.authorCouch, Fergus J
dc.contributor.authorNord, Silje
dc.contributor.authorEaston, Douglas F
dc.contributor.authorAntoniou, Antonis C
dc.contributor.authorSimard, Jacques
dc.date.accessioned2019-10-08T10:28:42Z
dc.date.available2019-10-08T10:28:42Z
dc.date.issued2017-01
dc.identifier.citationBreast Cancer Res Treat. 2017 Jan;161(1):117-134es_ES
dc.identifier.issn0167-6806es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8485
dc.description.abstractPURPOSE: Cis-acting regulatory SNPs resulting in differential allelic expression (DAE) may, in part, explain the underlying phenotypic variation associated with many complex diseases. To investigate whether common variants associated with DAE were involved in breast cancer susceptibility among BRCA1 and BRCA2 mutation carriers, a list of 175 genes was developed based of their involvement in cancer-related pathways. METHODS: Using data from a genome-wide map of SNPs associated with allelic expression, we assessed the association of ~320 SNPs located in the vicinity of these genes with breast and ovarian cancer risks in 15,252 BRCA1 and 8211 BRCA2 mutation carriers ascertained from 54 studies participating in the Consortium of Investigators of Modifiers of BRCA1/2. RESULTS: We identified a region on 11q22.3 that is significantly associated with breast cancer risk in BRCA1 mutation carriers (most significant SNP rs228595 p = 7 × 10-6). This association was absent in BRCA2 carriers (p = 0.57). The 11q22.3 region notably encompasses genes such as ACAT1, NPAT, and ATM. Expression quantitative trait loci associations were observed in both normal breast and tumors across this region, namely for ACAT1, ATM, and other genes. In silico analysis revealed some overlap between top risk-associated SNPs and relevant biological features in mammary cell data, which suggests potential functional significance. CONCLUSION: We identified 11q22.3 as a new modifier locus in BRCA1 carriers. Replication in larger studies using estrogen receptor (ER)-negative or triple-negative (i.e., ER-, progesterone receptor-, and HER2-negative) cases could therefore be helpful to confirm the association of this locus with breast cancer risk.es_ES
dc.description.sponsorshipFunding for the iCOGS infrastructure came from the European Community's Seventh Framework Programme under Grant Agreement No. 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-cancer GWAS Initiative (1U19 CA148537, 1U19 CA148065, and 1U19 CA148112: the GAME-ON Initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. BCFR: this work was supported by Grant UM1 CA164920 from the National Cancer Institute. BFBOCC was supported by Lithuania (BFBOCC-LT): Research Council of Lithuania Grant SEN-18/2015. BIDMC was supported by the Breast Cancer Research Foundation. BRCA-gene mutations and breast cancer in South African women (BMBSA) was supported by Grants from the Cancer Association of South Africa (CANSA) to Elizabeth J. van Rensburg. BRICOH: SLN was partially supported by the Morris and Horowitz Families Endowed Professorship. CNIO: this work was partially supported by Spanish Association Against Cancer (AECC08), RTICC 06/0020/1060, FISPI08/1120, Mutua Madrilena Foundation (FMMA), and SAF2010-20493. COH-CCGCRN: patients were recruited for this study from the City of Hope Clinical Cancer Genomics Community Research Network, supported in part by Award Number RC4CA153828 (PI: J. Weitzel) from the National Cancer Institute and the Office of the Director, National Institutes of Health. CONSIT Team: Associazione Italiana Ricerca sul Cancro (AIRC) to P. Peterlongo (IG 2012 Id. 12821) and P. Radice (IG 2014 Id. 15547). Funds from Italian citizens who allocated the 5 9 1000 share of their tax payment in support of the Fondazione IRCCS Istituto Nazionale Tumori, according to Italian laws (INT-Institutional Strategic Projects '5x1000') to S. Manoukian. FiorGen Foundation for Pharmacogenomics to L. Papi. CORE: the CIMBA Data Management and Data Analysis were supported by Cancer Research: UK Grants C12292/A20861, C12292/A11174. ACA is a Cancer Research-UK Senior Cancer Research Fellow. GCT is an NHMRC Senior Principal Research Fellow. J. Lecarpentier has been financially supported by the Fondation ARC (FONDATION ARC, 9 rue Guy Moquet 94803 Villejuif: France), Grant Number SAE20131200623. This work was supported by the Canadian Institutes of Health Research for the "CIHR Team in Familial Risks of Breast Cancer" Program: Grant No. CRN-87521 and the Ministry of Economic Development, Innovation and Export Trade: Grant No. PSR-SIIRI-701. The PERSPECTIVE Project was supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the Ministere de l'Economie, Innovation et Exportation du Quebec through Genome Quebec, and The Quebec Breast Cancer Foundation. This work was also supported by the Ministere de l'Economie, Innovation et Exportation du Quebec: Grant No. PSR-SIIRI-701. DEMOKRITOS: this research has been co-financed by the European Union (European Social Fund: ESF) and Greek National Funds through the Operational Program "Education and Lifelong Learning" of the National Strategic Reference Framework (NSRF): Research Funding Program of the General Secretariat for Research and Technology: SYN11_10_19 NBCA. Investing in Knowledge Society through the European Social Fund. The DKFZ Study was supported by the DKFZ. EMBRACE was supported by Cancer Research UK Grants C1287/A10118 and C1287/A11990. D. Gareth Evans and Fiona Lalloo were supported by an NIHR Grant to the Biomedical Research Centre, Manchester. The Investigators at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust were supported by an NIHR Grant to the Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. Ros Eeles and Elizabeth Bancroft were supported by Cancer Research UK Grant C5047/A8385. Ros Eeles was also supported by NIHR support to the Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. FCCC: the authors acknowledge the support from The University of Kansas Cancer Center (P30 CA168524) and the Kansas Bioscience Authority Eminent Scholar Program. A.K.G. was funded by 5U01CA113916, R01CA140323, and by the Chancellors Distinguished Chair in Biomedical Sciences Professorship. The German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC) was supported by the German Cancer Aid (Grant No. 110837, Rita K. Schmutzler). This work was supported by the European Regional Development Fund and Free State of Saxony, Germany (LIFE: Leipzig Research Centre for Civilization Diseases, Project Numbers 713-241202, 713-241202, 14505/2470, 14575/2470). GEMO: the study was supported by the Ligue Nationale Contre le Cancer; the Association "Le cancer du sein, parlons-en!" Award; the Canadian Institutes of Health Research for the "CIHR Team in Familial Risks of Breast Cancer" Program and the French National Institute of Cancer (INCa). GEORGETOWN: CI received support from the Non-therapeutic Subject Registry Shared Resource at Georgetown University (NIH/NCI Grant P30-CA051008), the Fisher Center for Hereditary Cancer and Clinical GenomicsResearch, and Swing Fore the Cure. G-FAST: Bruce Poppe is a Senior Clinical Investigator of FWO. Mattias Van Heetvelde obtained funding from IWT. HCSC was supported by a Grant RD12/0036/0006 and 15/00059 from ISCIII (Spain), partially supported by European Regional Development FEDER Funds. The HEBCS was financially supported by the Helsinki University Hospital Research Fund, Academy of Finland (266528), the Finnish Cancer Society and the Sigrid Juselius Foundation. HEBON Study was supported by the Dutch Cancer Society Grants NKI1998-1854, NKI2004-3088, and NKI2007-3756, the Netherlands Organization of Scientific Research Grant NWO 91109024, the Pink Ribbon Grants 110005 and 2014-187.WO76, the BBMRI Grant NWO 184.021.007/CP46, and the Transcan Grant JTC 2012 Cancer 12-054. HEBON thanks the Registration Teams of Dutch Cancer Registry (IKNL; S. Siesling, J. Verloop) and the Dutch Pathology database (PALGA; L. Overbeek) for their help in part of the data collection. HRBCP was supported by the Hong Kong Sanatorium and Hospital, Dr. Ellen Li Charitable Foundation, The Kerry Group Kuok Foundation, National Institute of Health 1R 03CA130065, and North California Cancer Center. Hungarian Breast and Ovarian Cancer Study (HUNBOCS) was supported by Hungarian Research Grants KTIA-OTKA CK-80745 and OTKA K-112228. ICO: Contract Grant Sponsor: Asociacion Espanola Contra el Cancer, Spanish Health Research Fund; Carlos III Health Institute; Catalan Health Institute and Autonomous Government of Catalonia. Contract Grant Numbers: ISCIIIRETIC RD06/0020/1051, RD12/0036/008, PI10/01422, PI10/00748, PI13/00285, PIE13/00022, 2009SGR290, and 2014SGR364. The IHCC was supported by Grant PBZ_KBN_122/P05/2004. The ILUH Group was supported by the Icelandic Association "Walking for Breast Cancer Research" and by the Landspitali University Hospital Research Fund. INHERIT: this work was supported by the Canadian Institutes of Health Research for the "CIHR Team in Familial Risks of Breast Cancer" Program: Grant No. CRN-87521 and the Ministry of Economic Development, Innovation and Export Trade: Grant No. PSR-SIIRI-701. The PERSPECTIVE Project was supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research (Grant GPH-129344), the Ministere de l'Economie, Science et Innovation du Quebec through Genome Quebec, and the Quebec Breast Cancer Foundation. IOVHBOCS was supported by Ministero della Salute and "5x1000" Istituto Oncologico Veneto Grant. IPOBCS: this study was in part supported by Liga Portuguesa Contra o Cancro. kConFab was supported by a Grant from the National Breast Cancer Foundation, and previously by the National Health and Medical Research Council (NHMRC), the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania, and South Australia, and the Cancer Foundation of Western Australia. KOHBRA was supported by a Grant from the National R&D Program for Cancer Control, Ministry for Health, Welfare and Family Affairs, Republic of Korea (1020350). MAYO was supported by NIH Grants CA116167, CA192393, and CA176785, an NCI Specialized Program of Research Excellence (SPORE) in Breast Cancer (CA116201), and a Grant from the Breast Cancer Research Foundation. MCGILL: Jewish General Hospital Weekend to End Breast Cancer, Quebec Ministry of Economic Development, Innovation and Export Trade. MODSQUAD was supported by MH CZ: DRO (MMCI, 00209805) and by the European Regional Development Fund and the State Budget of the Czech Republic (RECAMO, CZ.1.05/2.1.00/03.0101) to LF, and by Charles University in Prague Project UNCE204024 (MZ). MSKCC was supported by Grants from the Breast Cancer Research Foundation, the Robert and Kate Niehaus Clinical Cancer Genetics Initiative, and the Andrew Sabin Research Fund. NAROD: 1R01 CA149429-01. NCI: the research of Drs. MH Greene and PL Mai was supported by the Intramural Research Program of the US National Cancer Institute, NIH, and by Support Services Contracts NO2-CP-11019-50 and N02-CP-65504 with Westat, Inc., Rockville, MD. NICCC was supported by Clalit Health Services in Israel. Some of its activities were supported by the Israel Cancer Association and the Breast Cancer Research Foundation (BCRF), NY. NNPIO: this work has been supported by the Russian Federation for Basic Research (Grants 15-04-01744 and 16-54-00055). NRG Oncology: this study was supported by NRG Oncology Operations Grant Number U10 CA180868 as well as NRG SDMC Grant U10 CA180822, Gynecologic Oncology Group (GOG) Administrative Office and the GOG Tissue Bank (CA 27469), and the GOG Statistical and Data Center (CA 37517). Drs. Greene, Mai, and Savage were supported by Funding from the Intramural Research Program, NCI. OSUCCG was supported by the Ohio State University Comprehensive Cancer Center. PBCS: this work was supported by the Italian Association of Cancer Research (AIRC) [IG 2013 N.14477] and Tuscany Institute for Tumors (ITT) Grant 2014-2015-2016. SEABASS: Ministry of Science, Technology and Innovation, Ministry of Higher Education (UM.C/HlR/MOHE/06), and Cancer Research Initiatives Foundation. The SMC Team was in part sponsored by a Grant from the Israeli Cancer Association to the Israeli Consortium of Hereditary Breast Cancer. SWE-BRCA Collaborators were supported by the Swedish Cancer Society. UCHICAGO was supported by NCI Specialized Program of Research Excellence (SPORE) in Breast Cancer (CA125183), R01 CA142996, 1U01CA161032, and by the Ralph and Marion Falk Medical Research Trust, the Entertainment Industry Fund National Women's Cancer Research Alliance, and the Breast Cancer Research Foundation. OIO is an ACS Clinical Research Professor. UCLA: Jonsson Comprehensive Cancer Center Foundation; Breast Cancer Research Foundation. UCSF: UCSF Cancer Risk Program and Helen Diller Family Comprehensive Cancer Center. UKFOCR was supported by a Project Grant from CRUK to Paul Pharoah. UPENN: National Institutes of Health (NIH) (R01-CA102776 and R01-CA083855; Breast Cancer Research Foundation; Susan G. Komen Foundation for the Cure, Basser Research Center for BRCA. VFCTG: Victorian Cancer Agency, Cancer Australia, National Breast Cancer Foundation. WCP: Dr. Karlan was funded by the American Cancer Society Early Detection Professorship (SIOP-06-258-01-COUN) and the National Center for Advancing Translational Sciences (NCATS), Grant UL1TR000124.es_ES
dc.language.isoenges_ES
dc.publisherSPRINGERes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectBRCA1 and BRCA2 mutation carrierses_ES
dc.subjectBreast canceres_ES
dc.subjectCis-regulatory variantses_ES
dc.subjectDifferential allelic expressiones_ES
dc.subjectGenetic modifierses_ES
dc.subjectGenetic susceptibilityes_ES
dc.subject.meshBiomarkers, Tumor es_ES
dc.subject.meshBreast Neoplasms es_ES
dc.subject.meshChromosomes, Human, Pair 11 es_ES
dc.subject.meshFemale es_ES
dc.subject.meshGene Expression es_ES
dc.subject.meshGenetic Predisposition to Disease es_ES
dc.subject.meshGenetic Variation es_ES
dc.subject.meshHumans es_ES
dc.subject.meshQuantitative Trait Loci es_ES
dc.subject.meshRisk es_ES
dc.subject.meshAlleles es_ES
dc.subject.meshGenes, BRCA1 es_ES
dc.subject.meshGenes, BRCA2 es_ES
dc.subject.meshHeterozygote es_ES
dc.subject.meshMutation es_ES
dc.titleAssociation of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID27796716es_ES
dc.format.volume161es_ES
dc.format.number1es_ES
dc.format.page117-134es_ES
dc.identifier.doi10.1007/s10549-016-4018-2es_ES
dc.contributor.funderEuropean Research Council (ERC)es_ES
dc.contributor.funderCancer Research (UK)es_ES
dc.contributor.funderPost-cancer GWAS Initiativees_ES
dc.contributor.funderDepartment of Defence (USA)es_ES
dc.contributor.funderResearch Council of Lithuaniaes_ES
dc.contributor.funderAsociación Española Contra el Cánceres_ES
dc.contributor.funderRTICCes_ES
dc.contributor.funderCancer Research UKes_ES
dc.contributor.funderFondation ARC (FONDATION ARC)es_ES
dc.contributor.funderCanadian Institutes of Health Research (CIHR)es_ES
dc.contributor.funderMinistere de l'Economie, Innovation et Exportation (QUEBEC)es_ES
dc.contributor.funderUniversity of Kansas Cancer Centeres_ES
dc.contributor.funderDeutsche Krebshilfees_ES
dc.contributor.funderFree State of Saxony, Germany (LIFE: Leipzig Research Centre for Civilization Diseases)es_ES
dc.contributor.funderNon-therapeutic Subject Registry Shared Resource at Georgetown University (NIH/NCI)es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderAcademy of Finlandes_ES
dc.contributor.funderKWF Kankerbestrijdinges_ES
dc.contributor.funderNetherlands Organization for Scientific Research (NWO)es_ES
dc.contributor.funderPink Ribbon Grantses_ES
dc.contributor.funderBBMRIes_ES
dc.contributor.funderTranscan Grant JTC Canceres_ES
dc.contributor.funderHungarian Research Grantses_ES
dc.contributor.funderGeneralitat de Catalunyaes_ES
dc.contributor.funderMinistry of Health & Welfare, Republic of Koreaes_ES
dc.contributor.funderUnited States Department of Health & Human Services National Institutes of Health (NIH) - USAes_ES
dc.contributor.funderState Budget of the Czech Republic (RECAMO)es_ES
dc.contributor.funderCharles University in Praguees_ES
dc.contributor.funderWestat, Inc., Rockville, MDes_ES
dc.contributor.funderRussian Foundation for Basic Research (RFBR)es_ES
dc.contributor.funderGynecologic Oncology Group (GOG)es_ES
dc.contributor.funderAssociazione Italiana per la Ricerca sul Cancro (AIRC)es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1573-7217es_ES
dc.relation.publisherversionhttps://doi.org/10.1007/s10549-016-4018-2.es_ES
dc.identifier.journalBreast cancer research and treatmentes_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Genética Humanaes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
This item is licensed under a: Atribución-NoComercial-CompartirIgual 4.0 Internacional