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dc.contributor.author | Hurtado-Roca, Yamilee | |
dc.contributor.author | Bueno, Hector | |
dc.contributor.author | Fernandez-Ortiz, Antonio | |
dc.contributor.author | Ordovas, Jose M | |
dc.contributor.author | Ibáñez, Borja | |
dc.contributor.author | Fuster, Valentin | |
dc.contributor.author | Rodríguez-Artalejo, Fernando | |
dc.contributor.author | Laclaustra, Martin | |
dc.date.accessioned | 2019-09-17T06:52:23Z | |
dc.date.available | 2019-09-17T06:52:23Z | |
dc.date.issued | 2017-02 | |
dc.identifier.citation | Diabetes. 2017; 66(2):474-482 | es_ES |
dc.identifier.issn | 0012-1797 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/8355 | |
dc.description.abstract | This study assesses whether oxidative stress, using oxidized LDL (ox-LDL) as a proxy, is associated with metabolic syndrome (MS), whether ox-LDL mediates the association between central obesity and MS, and whether insulin resistance mediates the association between ox-LDL and MS. We examined baseline data from 3,987 subjects without diabetes in the Progression of Early Subclinical Atherosclerosis (PESA) Study. For the second, third, and fourth ox-LDL quartiles versus the first, the odds ratios (95% CI) for MS were 0.84 (0.52, 1.36), 1.47 (0.95, 2.32), and 2.57 (1.66, 4.04) (P < 0.001 for trend) once adjusted for age, sex, smoking, LDL-cholesterol, BMI, waist circumference, and HOMA-insulin resistance (HOMA-IR). Results showing the same trend were found for all MS components except glucose concentration. Ox-LDL mediated 13.9% of the association of waist circumference with triglycerides and only 1-3% of the association with HDL-cholesterol, blood pressure, and insulin concentration. HOMA-IR did not mediate the association between ox-LDL and MS components. This study found higher ox-LDL concentrations were associated with MS and its components independently of central obesity and insulin resistance. Ox-LDL may reflect core mechanisms through which MS components develop and progress in parallel with insulin resistance and could be a clinically relevant predictor of MS development. | es_ES |
dc.description.sponsorship | Y.H.-R. received support from Republic of Peru and the Inter-American Development Bank through FINCyT Science and Technology Program Scholarships No. 088-FINCyT-BDE-2014 under agreement 1663/OC-PE. M.L. received partial support from the Institute de Salud Carlos III, cofunded by the European Regional Development Fund/European Social Fund, "Investing in Your Future" grants PI10/00021 and PI14/00009. The PESA study is supported by a noncompetitive unrestricted grant shared between the CNIC and Santander Bank. The CNIC is supported by the Spanish Ministry of Economy and Competitiveness (MINECO) and the Pro-CNIC Foundation and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Diabetes Association (ADA) | es_ES |
dc.type.hasVersion | AM | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Adult | es_ES |
dc.subject.mesh | Blood Glucose | es_ES |
dc.subject.mesh | Blood Pressure | es_ES |
dc.subject.mesh | Body Mass Index | es_ES |
dc.subject.mesh | Cholesterol, HDL | es_ES |
dc.subject.mesh | Cholesterol, LDL | es_ES |
dc.subject.mesh | Cohort Studies | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Insulin | es_ES |
dc.subject.mesh | Lipoproteins, LDL | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Metabolic Syndrome | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Obesity, Abdominal | es_ES |
dc.subject.mesh | Odds Ratio | es_ES |
dc.subject.mesh | Smoking | es_ES |
dc.subject.mesh | Triglycerides | es_ES |
dc.subject.mesh | Waist Circumference | es_ES |
dc.subject.mesh | Insulin Resistance | es_ES |
dc.subject.mesh | Oxidative Stress | es_ES |
dc.title | Oxidized LDL Is Associated With Metabolic Syndrome Traits Independently of Central Obesity and Insulin Resistance | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 27993926 | es_ES |
dc.format.volume | 66 | es_ES |
dc.format.number | 2 | es_ES |
dc.format.page | 474-482 | es_ES |
dc.identifier.doi | 10.2337/db16-0933 | es_ES |
dc.contributor.funder | Centro Nacional de Investigaciones Cardiovasculares Carlos III (España) | |
dc.contributor.funder | Banco Santander | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Fundación ProCNIC | |
dc.contributor.funder | Ministerio de la Producción (Perú) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1939-327X | es_ES |
dc.relation.publisherversion | https://doi.org/10.2337/db16-0933 | es_ES |
dc.identifier.journal | Diabetes | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionales | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovascular | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Investigación Cardiovascular Traslacional Multidisciplinaria | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/00009 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI10/00021 | es_ES |
dc.rights.accessRights | open access | es_ES |