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dc.contributor.authorHurtado-Roca, Yamilee 
dc.contributor.authorBueno, Héctor 
dc.contributor.authorFernandez-Ortiz, Antonio 
dc.contributor.authorOrdovas, Jose M 
dc.contributor.authorIbanez, Borja 
dc.contributor.authorFuster, Valentin 
dc.contributor.authorRodríguez-Artalejo, Fernando
dc.contributor.authorLaclaustra, Martin
dc.identifier.citationDiabetes. 2017; 66(2):474-482es_ES
dc.description.abstractThis study assesses whether oxidative stress, using oxidized LDL (ox-LDL) as a proxy, is associated with metabolic syndrome (MS), whether ox-LDL mediates the association between central obesity and MS, and whether insulin resistance mediates the association between ox-LDL and MS. We examined baseline data from 3,987 subjects without diabetes in the Progression of Early Subclinical Atherosclerosis (PESA) Study. For the second, third, and fourth ox-LDL quartiles versus the first, the odds ratios (95% CI) for MS were 0.84 (0.52, 1.36), 1.47 (0.95, 2.32), and 2.57 (1.66, 4.04) (P < 0.001 for trend) once adjusted for age, sex, smoking, LDL-cholesterol, BMI, waist circumference, and HOMA-insulin resistance (HOMA-IR). Results showing the same trend were found for all MS components except glucose concentration. Ox-LDL mediated 13.9% of the association of waist circumference with triglycerides and only 1-3% of the association with HDL-cholesterol, blood pressure, and insulin concentration. HOMA-IR did not mediate the association between ox-LDL and MS components. This study found higher ox-LDL concentrations were associated with MS and its components independently of central obesity and insulin resistance. Ox-LDL may reflect core mechanisms through which MS components develop and progress in parallel with insulin resistance and could be a clinically relevant predictor of MS development.es_ES
dc.description.sponsorshipY.H.-R. received support from Republic of Peru and the Inter-American Development Bank through FINCyT Science and Technology Program Scholarships No. 088-FINCyT-BDE-2014 under agreement 1663/OC-PE. M.L. received partial support from the Institute de Salud Carlos III, cofunded by the European Regional Development Fund/European Social Fund, "Investing in Your Future" grants PI10/00021 and PI14/00009. The PESA study is supported by a noncompetitive unrestricted grant shared between the CNIC and Santander Bank. The CNIC is supported by the Spanish Ministry of Economy and Competitiveness (MINECO) and the Pro-CNIC Foundation and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505).es_ES
dc.publisherAmerican Diabetes Associationes_ES
dc.subject.meshAdult es_ES
dc.subject.meshBlood Glucose es_ES
dc.subject.meshBlood Pressure es_ES
dc.subject.meshBody Mass Index es_ES
dc.subject.meshCholesterol, HDL es_ES
dc.subject.meshCholesterol, LDL es_ES
dc.subject.meshCohort Studies es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshInsulin es_ES
dc.subject.meshLipoproteins, LDL es_ES
dc.subject.meshMale es_ES
dc.subject.meshMetabolic Syndrome es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshObesity, Abdominal es_ES
dc.subject.meshOdds Ratio es_ES
dc.subject.meshSmoking es_ES
dc.subject.meshTriglycerides es_ES
dc.subject.meshWaist Circumference es_ES
dc.subject.meshInsulin Resistance es_ES
dc.subject.meshOxidative Stress es_ES
dc.titleOxidized LDL Is Associated With Metabolic Syndrome Traits Independently of Central Obesity and Insulin Resistancees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.contributor.funderCentro Nacional de Investigaciones Cardiovasculares (CNIC)es_ES
dc.contributor.funderBanco Santanderes_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderFundación ProCNICes_ES
dc.contributor.funderMinisterio de la Producción (Perú)es_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionaleses_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovasculares_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Investigación Cardiovascular Traslacional Multidisciplinariaes_ES

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional