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dc.contributor.authorVillalba-Orero, Maria 
dc.contributor.authorLopez-Olaneta, Marina 
dc.contributor.authorGonzalez-Lopez, Esther 
dc.contributor.authorPadron-Barthe, Laura 
dc.contributor.authorGomez-Salinero, Jesus M. 
dc.contributor.authorGarcia-Prieto, Jaime 
dc.contributor.authorWai, Timothy
dc.contributor.authorGarcía-Pavía, Pablo
dc.contributor.authorIbanez, Borja 
dc.contributor.authorJimenez-Borreguero, Luis J. 
dc.contributor.authorLara-Pezzi, Enrique
dc.identifier.citationCardiovasc Res. 2017; 113(10):1113-23es_ES
dc.description.abstractAims: Heart failure (HF) has become an epidemic and constitutes a major medical, social, and economic problem worldwide. Despite advances in medical treatment, HF prognosis remains poor. The development of efficient therapies is hampered by the lack of appropriate animal models in which HF can be reliably determined, particularly in mice. The development of HF in mice is often assumed based on the presence of cardiac dysfunction, but HF itself is seldom proved. Lung ultrasound (LUS) has become a helpful tool for lung congestion assessment in patients at all stages of HF. We aimed to apply this non-invasive imaging tool to evaluate HF in mouse models of both systolic and diastolic dysfunction. Methods and results: We used LUS to study HF in a mouse model of systolic dysfunction, dilated cardiomyopathy, and in a mouse model of diastolic dysfunction, diabetic cardiomyopathy. LUS proved to be a reliable and reproducible tool to detect pulmonary congestion in mice. The combination of LUS and echocardiography allowed discriminating those mice that develop HF from those that do not, even in the presence of evident cardiac dysfunction. The study showed that LUS can be used to identify the onset of HF decompensation and to evaluate the efficacy of therapies for this syndrome. Conclusions: This novel approach in mouse models of cardiac disease enables for the first time to adequately diagnose HF non-invasively in mice with preserved or reduced ejection fraction, and will pave the way to a better understanding of HF and to the development of new therapeutic approaches.es_ES
dc.description.sponsorshipThis study was supported by grants from the Spanish Ministerio de Economia y Competitividad (SAF2015-65722-R), Comunidad Autonoma de Madrid (2010-BMD2321, FIBROTEAM Consortium), European Union's FP7 (CardioNeT-ITN-289600, CardioNext-ITN-608027) and the Spanish Instituto de Salud Carlos III (CPII14/00027 to E.L-P, RD12/0042/0054 to B.I. and RD12/0042/066 to P.G.-P. and E.L-P). This work was also supported by the Plan Estatal de I+D+I 2013-2016 - European Regional Development Fund (FEDER) "A way of making Europe", Spain. The CNIC is supported by the Ministry of Economy, Industry and Competitiveness (MINECO) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505).es_ES
dc.publisherEuropean Society of Cardiologyes_ES
dc.subjectAnimal models of heart failurees_ES
dc.subjectHeart failurees_ES
dc.subjectLung ultrasoundes_ES
dc.subjectTranslational modelses_ES
dc.subject.meshAnimals es_ES
dc.subject.meshCardiomyopathy, Dilated es_ES
dc.subject.meshDiabetic Cardiomyopathies es_ES
dc.subject.meshDiastole es_ES
dc.subject.meshDisease Models, Animales_ES
dc.subject.meshEchocardiography, Doppler, Pulsed es_ES
dc.subject.meshHeart Failure es_ES
dc.subject.meshLung es_ES
dc.subject.meshMale es_ES
dc.subject.meshMice, Inbred C57BL es_ES
dc.subject.meshMice, Transgenic es_ES
dc.subject.meshPleural Effusion es_ES
dc.subject.meshPredictive Value of Tests es_ES
dc.subject.meshPulmonary Edema es_ES
dc.subject.meshReproducibility of Results es_ES
dc.subject.meshStroke Volume es_ES
dc.subject.meshSystole es_ES
dc.subject.meshTranslational Medical Research es_ES
dc.subject.meshUltrasonography es_ES
dc.subject.meshVentricular Function, Right es_ES
dc.subject.meshVentricular Function, Left es_ES
dc.titleLung ultrasound as a translational approach for non-invasive assessment of heart failure with reduced or preserved ejection fraction in micees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderComunidad de Madrides_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderFundación ProCNICes_ES
dc.identifier.journalCardiovascular researches_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Regulación Molecular de la Insuficiencia Cardiacaes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovasculares_ES

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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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