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dc.contributor.authorPanse, Kalyani D
dc.contributor.authorFelkin, Leanne E
dc.contributor.authorLopez-Olaneta, Marina 
dc.contributor.authorGomez-Salinero, Jesus M. 
dc.contributor.authorVillalba-Orero, Maria 
dc.contributor.authorMunoz, Lucia 
dc.contributor.authorNakamura, Kazuto
dc.contributor.authorShimano, Masayuki
dc.contributor.authorWalsh, Kenneth
dc.contributor.authorBarton, Paul J R
dc.contributor.authorRosenthal, Nadia
dc.contributor.authorLara-Pezzi, Enrique 
dc.date.accessioned2019-07-29T13:05:32Z
dc.date.available2019-07-29T13:05:32Z
dc.date.issued2012-12
dc.identifier.citationJ Cardiovasc Transl Res. 2012; 5(6):814-26es_ES
dc.identifier.issn1937-5387es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7981
dc.description.abstractFollistatins are extracellular inhibitors of the TGF-β family ligands including activin A, myostatin and bone morphogenetic proteins. Follistatin-like 3 (FSTL3) is a potent inhibitor of activin signalling and antagonises the cardioprotective role of activin A in the heart. FSTL3 expression is elevated in patients with heart failure and is upregulated in cardiomyocytes by hypertrophic stimuli, but its role in cardiac remodelling is largely unknown. Here, we show that the production of FSTL3 by cardiomyocytes contributes to the paracrine activation of cardiac fibroblasts, inducing changes in cell adhesion, promoting proliferation and increasing collagen production. We found that FSTL3 is necessary for this response and for the induction of cardiac fibrosis. However, full activation requires additional factors, and we identify connective tissue growth factor as a FSTL3 binding partner in this process. Together, our data unveil a novel mechanism of paracrine communication between cardiomyocytes and fibroblasts that may provide potential as a therapeutic target in heart remodelling.es_ES
dc.description.sponsorshipBritish Heart Foundation [PG/08/084/25827]; Heart Research UK; National Institute for Health Research Cardiovascular Biomedical Research Unit at the Royal Brompton; Harefield NHS Foundation Trust; Imperial College; European Union [ERG-239158, ITN-289600]; Spanish Ministry of Science and Innovation [BFU2009-10016, CP08/00144]; Regional Government of Madrid [S2010/BMD-2321 'Fibroteam']es_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshAnimals es_ES
dc.subject.meshCell Adhesion es_ES
dc.subject.meshCell Proliferation es_ES
dc.subject.meshCells, Cultured es_ES
dc.subject.meshCoculture Techniques es_ES
dc.subject.meshCollagen es_ES
dc.subject.meshConnective Tissue Growth Factor es_ES
dc.subject.meshDisease Models, Animales_ES
dc.subject.meshFibroblasts es_ES
dc.subject.meshFibrosis es_ES
dc.subject.meshFollistatin-Related Proteins es_ES
dc.subject.meshGene Expression Regulation es_ES
dc.subject.meshHeart Failure es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMice es_ES
dc.subject.meshMice, Inbred C57BL es_ES
dc.subject.meshMice, Knockout es_ES
dc.subject.meshMyocytes, Cardiaces_ES
dc.subject.meshProteins es_ES
dc.subject.meshRats es_ES
dc.subject.meshSignal Transduction es_ES
dc.subject.meshTime Factors es_ES
dc.subject.meshParacrine Communication es_ES
dc.titleFollistatin-like 3 mediates paracrine fibroblast activation by cardiomyocyteses_ES
dc.typeArtículoes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID22915069es_ES
dc.format.volume5es_ES
dc.format.number6es_ES
dc.format.page814-26es_ES
dc.identifier.doi10.1007/s12265-012-9400-9es_ES
dc.contributor.funderBritish Heart Foundationes_ES
dc.contributor.funderNational Institute for Health Research (United Kingdom)es_ES
dc.contributor.funderNHS Foundation Trusth (United Kingdom)es_ES
dc.contributor.funderImperian College (United Kingdom)es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderComunidad de Madrides_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1937-5395es_ES
dc.relation.publisherversionhttps://doi.org/10.1007/s12265-012-9400-9es_ES
dc.identifier.journalJournal of cardiovascular translational researches_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Regulación Molecular de la Insuficiencia Cardiacaes_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/289600/EUes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/239158/EUes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BFU2009-10016es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CP08/00144es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional