Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/7846
cDC1s: New Orchestrators of Tissue Innate Immunity
Trends Immunol. 2019; 40(7):559-561
Type-I conventional dendritic cells (cDC1s) are key in inducing adaptive immunity. Using single-cell sequencing, Ginhoux and colleagues (Immunity 2019;50:1069-1083.e8) find that a subset of activated cDC1s in bacteria-infected skin is critical for neutrophil recruitment via the production of VEGF-α. These results reveal a crucial function for cDC1s beyond antigen presentation.