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dc.contributor.author | Fuster, Jose J. | |
dc.contributor.author | Castillo, Ana I | |
dc.contributor.author | Zaragoza, Carlos | |
dc.contributor.author | Ibáñez, Borja | |
dc.contributor.author | Andres, Vicente | |
dc.date.accessioned | 2019-05-23T09:29:23Z | |
dc.date.available | 2019-05-23T09:29:23Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Prog Mol Biol Transl Sci. 2012; 105:1-23 | es_ES |
dc.identifier.issn | 18771173 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/7661 | |
dc.description.abstract | Cardiovascular disease is currently the predominant cause of mortality worldwide and its incidence is expected to increase significantly during the next decades owing to the unhealthy effects of modern lifestyle habits (e.g., obesity and lack of physical exercise). Cardiovascular death is frequently associated with acute myocardial infarction or stroke, which are generally the ultimate consequence of an underlying atherosclerotic process. Small and big animal models are valuable tools to understand the molecular mechanisms underlying atherosclerotic plaque formation and progression, as well as the occurrence of associated ischemic events. Moreover, animal models of atherosclerosis are pivotal for testing mechanistic hypothesis and for translational research, including the assessment of dietary and/or pharmacological interventions and the development of imaging technologies and interventional devices. In this chapter, we will describe the most widely used animal models that have permitted major advances in atherosclerosis research and significant improvements in the treatment and diagnosis of atherosclerotic disease. | es_ES |
dc.description.sponsorship | Work in the author’s laboratories is supported by the Spanish Ministry of Science and Innovation (MICINN) (grants SAF2010-16044 and SAF2008-04629) and Fondo de Investigacion Sanitaria—Instituto de Salud Carlos III (RECAVA: grant RD06/0014/0021 and PI10/02268). The CNIC is supported by the MICINN and the Pro-CNIC Foundation | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | AM | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Atherosclerosis | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Disease Models, Animal | es_ES |
dc.title | Animal models of atherosclerosis | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 22137427 | es_ES |
dc.format.volume | 105 | es_ES |
dc.format.page | 1-23 | es_ES |
dc.identifier.doi | 10.1016/B978-0-12-394596-9.00001-9 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Fundación ProCNIC | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1878-0814 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/B978-0-12-394596-9.00001-9 | es_ES |
dc.identifier.journal | Progress in molecular biology and translational science | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Fisiopatología Cardiovascular Molecular y Genética | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovascular | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Antiguos CNIC | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2010-16044 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2008-04629 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD06/0014/0021 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI10/02268 | es_ES |
dc.rights.accessRights | open access | es_ES |