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dc.contributor.authorFuster, Jose J. 
dc.contributor.authorCastillo, Ana I 
dc.contributor.authorZaragoza, Carlos 
dc.contributor.authorIbanez, Borja 
dc.contributor.authorAndres, Vicente 
dc.date.accessioned2019-05-23T09:29:23Z
dc.date.available2019-05-23T09:29:23Z
dc.date.issued2012
dc.identifier.citationProg Mol Biol Transl Sci. 2012; 105:1-23es_ES
dc.identifier.issn18771173es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7661
dc.description.abstractCardiovascular disease is currently the predominant cause of mortality worldwide and its incidence is expected to increase significantly during the next decades owing to the unhealthy effects of modern lifestyle habits (e.g., obesity and lack of physical exercise). Cardiovascular death is frequently associated with acute myocardial infarction or stroke, which are generally the ultimate consequence of an underlying atherosclerotic process. Small and big animal models are valuable tools to understand the molecular mechanisms underlying atherosclerotic plaque formation and progression, as well as the occurrence of associated ischemic events. Moreover, animal models of atherosclerosis are pivotal for testing mechanistic hypothesis and for translational research, including the assessment of dietary and/or pharmacological interventions and the development of imaging technologies and interventional devices. In this chapter, we will describe the most widely used animal models that have permitted major advances in atherosclerosis research and significant improvements in the treatment and diagnosis of atherosclerotic disease.es_ES
dc.description.sponsorshipWork in the author’s laboratories is supported by the Spanish Ministry of Science and Innovation (MICINN) (grants SAF2010-16044 and SAF2008-04629) and Fondo de Investigacion Sanitaria—Instituto de Salud Carlos III (RECAVA: grant RD06/0014/0021 and PI10/02268). The CNIC is supported by the MICINN and the Pro-CNIC Foundationes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshAnimals es_ES
dc.subject.meshAtherosclerosis es_ES
dc.subject.meshHumans es_ES
dc.subject.meshDisease Models, Animales_ES
dc.titleAnimal models of atherosclerosises_ES
dc.typeArtículoes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID22137427es_ES
dc.format.volume105es_ES
dc.format.page1-23es_ES
dc.identifier.doi10.1016/B978-0-12-394596-9.00001-9es_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)
dc.contributor.funderInstituto de Salud Carlos III - ISCIII
dc.contributor.funderFundación ProCNIC
dc.description.peerreviewedes_ES
dc.identifier.e-issn1878-0814es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/B978-0-12-394596-9.00001-9es_ES
dc.identifier.journalProgress in molecular biology and translational sciencees_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Fisiopatología Cardiovascular Molecular y Genéticaes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovasculares_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Antiguos CNICes_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2010-16044es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2008-04629es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD06/0014/0021es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI10/02268es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional