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dc.contributor.authorMenchero, Sergio 
dc.contributor.authorRollan, Isabel 
dc.contributor.authorLopez-Izquierdo, Antonio 
dc.contributor.authorAndreu, Maria Jose 
dc.contributor.authorSainz de Aja, Julio 
dc.contributor.authorKang, Minjung
dc.contributor.authorAdan, Javier 
dc.contributor.authorBenedito, Rui 
dc.contributor.authorRayon, Teresa 
dc.contributor.authorHadjantonakis, Anna-Katerina
dc.contributor.authorManzanares, Miguel 
dc.date.accessioned2019-05-17T09:16:01Z
dc.date.available2019-05-17T09:16:01Z
dc.date.issued2019-04-08
dc.identifier.citationElife. 2019; 8:e42930es_ES
dc.identifier.issn2050-084Xes_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7579
dc.description.abstractThe Notch signalling pathway plays fundamental roles in diverse developmental processes in metazoans, where it is important in driving cell fate and directing differentiation of various cell types. However, we still have limited knowledge about the role of Notch in early preimplantation stages of mammalian development, or how it interacts with other signalling pathways active at these stages such as Hippo. By using genetic and pharmacological tools in vivo, together with image analysis of single embryos and pluripotent cell culture, we have found that Notch is active from the 4-cell stage. Transcriptomic analysis in single morula identified novel Notch targets, such as early naïve pluripotency markers or transcriptional repressors such as TLE4. Our results reveal a previously undescribed role for Notch in driving transitions during the gradual loss of potency that takes place in the early mouse embryo prior to the first lineage decisions.es_ES
dc.description.sponsorshipThis work was supported by the Spanish government (grants BFU2017-84914-P and BFU2015-72319-EXP to MM; FPI-SO Fellowship to SM); and grants NIH-R01DK084391, NIH-R01HD094868 and NIH-P30CA008748 to AKH. The CNIC is supported by the Spanish Ministry of Science, Innovation and Universities and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505).es_ES
dc.language.isoenges_ES
dc.publishereLife Sciences Publicationses_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCdx2es_ES
dc.subjectchromosomeses_ES
dc.subjectdevelopmental biologyes_ES
dc.subjectgene expressiones_ES
dc.subjectmorulaes_ES
dc.subjectmousees_ES
dc.subjectnotches_ES
dc.subjectpreimplantation developmentes_ES
dc.subjecttrophectodermes_ES
dc.titleTransitions in cell potency during early mouse development are driven by Notches_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID30958266es_ES
dc.format.volume8es_ES
dc.identifier.doi10.7554/eLife.42930es_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderFundación ProCNICes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2050-084Xes_ES
dc.relation.publisherversionhttps://doi.org/10.7554/eLife.42930es_ES
dc.identifier.journaleLifees_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Genómica Funcionales_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Genética Molecular de la Angiogénesises_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BFU2017-84914-Pes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BFU2015-72319-EXPes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución 4.0 Internacional
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