Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/7525
Título
Superparamagnetic Nanoparticles for Atherosclerosis Imaging
Autor(es)
Herranz, Fernando CNIC | Salinas, Beatriz CNIC | Groult, Hugo CNIC | Pellico, Juan CNIC | Lechuga-Vieco, Ana V. CNIC | Bhavesh, Riju CNIC | Ruiz-Cabello, Jesus CNIC
Fecha de publicación
2014-06-05
Cita
Nanomaterials (Basel). 2014; 4(2):408-438
Idioma
Inglés
Tipo de documento
journal article
Resumen
The production of magnetic nanoparticles of utmost quality for biomedical imaging requires several steps, from the synthesis of highly crystalline magnetic cores to the attachment of the different molecules on the surface. This last step probably plays the key role in the production of clinically useful nanomaterials. The attachment of the different biomolecules should be performed in a defined and controlled fashion, avoiding the random adsorption of the components that could lead to undesirable byproducts and ill-characterized surface composition. In this work, we review the process of creating new magnetic nanomaterials for imaging, particularly for the detection of atherosclerotic plaque, in vivo. Our focus will be in the different biofunctionalization techniques that we and several other groups have recently developed. Magnetic nanomaterial functionalization should be performed by chemoselective techniques. This approach will facilitate the application of these nanomaterials in the clinic, not as an exception, but as any other pharmacological compound.
Palabras clave
Atherosclerosis plaque | Cardiovascular imaging | Chemoselective functionalization | Iron oxide nanoparticles
Versión en línea
DOI
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