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dc.contributor.authorRingenberg, Jordan
dc.contributor.authorDeo, Makarand
dc.contributor.authorFilgueiras-Rama, David 
dc.contributor.authorPizarro, Gonzalo 
dc.contributor.authorIbanez, Borja 
dc.contributor.authorPeinado, Rafael
dc.contributor.authorMerino, José L.
dc.contributor.authorBerenfeld, Omer
dc.contributor.authorDevabhaktuni, Vijay
dc.identifier.citationClin Med Insights Cardiol. 2014; 8(Suppl 1):1-13es_ES
dc.description.abstractMyocardial fibrosis detected via delayed-enhanced magnetic resonance imaging (MRI) has been shown to be a strong indicator for ventricular tachycardia (VT) inducibility. However, little is known regarding how inducibility is affected by the details of the fibrosis extent, morphology, and border zone configuration. The objective of this article is to systematically study the arrhythmogenic effects of fibrosis geometry and extent, specifically on VT inducibility and maintenance. We present a set of methods for constructing patient-specific computational models of human ventricles using in vivo MRI data for patients suffering from hypertension, hypercholesterolemia, and chronic myocardial infarction. Additional synthesized models with morphologically varied extents of fibrosis and gray zone (GZ) distribution were derived to study the alterations in the arrhythmia induction and reentry patterns. Detailed electrophysiological simulations demonstrated that (1) VT morphology was highly dependent on the extent of fibrosis, which acts as a structural substrate, (2) reentry tended to be anchored to the fibrosis edges and showed transmural conduction of activations through narrow channels formed within fibrosis, and (3) increasing the extent of GZ within fibrosis tended to destabilize the structural reentry sites and aggravate the VT as compared to fibrotic regions of the same size and shape but with lower or no GZ. The approach and findings represent a significant step toward patient-specific cardiac modeling as a reliable tool for VT prediction and management of the patient. Sensitivities to approximation nuances in the modeling of structural pathology by image-based reconstruction techniques are also implicated.es_ES
dc.description.sponsorshipMakarand Deo is supported by American heart association scientist development grant no. 12sdg11480010. the work is also supported by Pro CniC Foundation, Eugenio Rodríguez Pascual Foundation, Fondo Europeo de Desarrollo Regional (Feder), European Union, and Instituto de Salud Carlos iii, Spain [rd12/0042/0036 (RIC)] (David Filgueiras-Rama, Gonzalo Pizarro, and Borja ibañez).es_ES
dc.subjectCardiac MRIes_ES
dc.subjectImage-based 3D ventricular modelinges_ES
dc.subjectVentricular tachycardiaes_ES
dc.titleEffects of Fibrosis Morphology on Reentrant Ventricular Tachycardia Inducibility and Simulation Fidelity in Patient-Derived Modelses_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial 4.0 Internacional*
dc.format.numberSuppl 1es_ES
dc.contributor.funderAmerican Heart Association 
dc.contributor.funderFundación ProCNIC 
dc.contributor.funderFundación Eugenio Rodríguez Pascual 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.contributor.funderUnión Europea 
dc.contributor.funderInstituto de Salud Carlos III 
dc.identifier.journalClinical Medicine Insights: Cardiologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovasculares_ES
dc.rights.accessRightsopen accesses_ES

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Atribución-NoComercial 4.0 Internacional
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