Mostrar el registro sencillo del ítem
dc.contributor.author | Jiménez-García, Manuel-Pedro | |
dc.contributor.author | Lucena-Cacace, Antonio | |
dc.contributor.author | Robles-Frías, María-José | |
dc.contributor.author | Ferrer, Irene | |
dc.contributor.author | Narlik-Grassow, Maja | |
dc.contributor.author | Blanco-Aparicio, Carmen | |
dc.contributor.author | Carnero, Amancio | |
dc.date.accessioned | 2019-03-14T12:27:17Z | |
dc.date.available | 2019-03-14T12:27:17Z | |
dc.date.issued | 2017-08-29 | |
dc.identifier.citation | Oncotarget. 2017 ;8(35):58872-58886 | es_ES |
dc.identifier.issn | 1949-2553 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/7335 | |
dc.description.abstract | The PIM family of Ser/Thr kinase proteins has been implicated in tumorigenesis at different levels. PIM proteins are overexpressed in several tumor types and have been associated with chemoresistance. However, their role in hormone-dependent female tissues has not been explored, especially in the uterus, breast and ovary. We generated conditional transgenic mice with confined expression of human PIM1 or PIM2 genes in these tissues. We characterized the tumoral response to these genetic alterations corroborating their role as oncogenes since they induce hyperproliferation in all tissues and tumors in mammary gland and uterus. Furthermore, we observed a high degree of inflammatory infiltration in these tissues of transgenic mice accompanied by NFAT and mTOR activation and IL6 expression. Moreover, PIM1/2 were overexpressed in human breast, uterine and ovarian tumors, correlating with inflammatory features and stem cell markers. Our data suggest that PIM1/2 kinase overexpression provoke tissue alterations and a large IL6-dependent inflammatory response that may act synergistically during the process of tumorigenesis. The possible end-point is an increased percentage of cancer stem cells, which may be partly responsible for the therapy resistance found in tumors overexpressing PIM kinases. | es_ES |
dc.description.sponsorship | This work was funded by grants from the Spanish Ministry of Economy and Competitivity, Plan Estatal de I+D+I 2013–2016, ISCIII (Fis: PI15/00045) and CIBER de Cáncer (CD16/12/00275), co-funded by FEDER from Regional Development European Funds (European www.impactjournals.com/oncotarget 58885 Oncotarget Union), Consejeria de Ciencia e Innovacion (CTS-1848) and Consejeria de Salud of the Junta de Andalucia (PI- 0096-2014). Especial thanks to the AECC Foundation for also supporting this work. This work has also been made possible by the Fundacion BBVA. The Spanish Ministry of Education (FPU13/00426) funded MPJG | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Impact Journals | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | PIM kinases | es_ES |
dc.subject | Conditional transgenic mice | es_ES |
dc.subject | Mammary tumors | es_ES |
dc.subject | Oncogenesis | es_ES |
dc.subject | Reproductive system tumors | es_ES |
dc.subject.mesh | Prostate | es_ES |
dc.subject.mesh | CHRONIC LYMPHOCYTIC-LEUKEMIA | es_ES |
dc.subject.mesh | PIM KINASES | es_ES |
dc.subject.mesh | SERINE/THREONINE KINASES | es_ES |
dc.subject.mesh | PANCREATIC-CANCER | es_ES |
dc.subject.mesh | Up-Regulation | es_ES |
dc.subject.mesh | Survival | es_ES |
dc.subject.mesh | Growth | es_ES |
dc.subject.mesh | Family | es_ES |
dc.title | Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 28938604 | es_ES |
dc.format.volume | 8 | es_ES |
dc.format.number | 35 | es_ES |
dc.format.page | 58872-58886 | es_ES |
dc.identifier.doi | 10.18632/oncotarget.19438 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Centro de Investigación Biomedica en Red - CIBER | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Regional Government of Andalusia (España) | |
dc.contributor.funder | Asociación Española Contra el Cáncer | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1949-2553 | es_ES |
dc.relation.publisherversion | https://doi.org/10.18632/oncotarget.19438. | es_ES |
dc.identifier.journal | Oncotarget | es_ES |
dc.repisalud.institucion | CNIO | es_ES |
dc.repisalud.orgCNIO | CNIO::Grupos de investigación::Sección de Biología | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI15/00045 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/CD16/12/00275 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/CTS-1848 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI-0096-2014 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/FPU13/00426 | es_ES |
dc.rights.accessRights | open access | es_ES |