Mostrar el registro sencillo del ítem
dc.contributor.author | Danne, Camille | |
dc.contributor.author | Ryzhakov, Grigory | |
dc.contributor.author | Martinez-Lopez, Maria | |
dc.contributor.author | Ilott, Nicholas Edward | |
dc.contributor.author | Franchini, Fanny | |
dc.contributor.author | Cuskin, Fiona | |
dc.contributor.author | Lowe, Elisabeth C | |
dc.contributor.author | Bullers, Samuel J | |
dc.contributor.author | Arthur, J Simon C | |
dc.contributor.author | Powrie, Fiona | |
dc.date.accessioned | 2019-03-11T08:52:41Z | |
dc.date.available | 2019-03-11T08:52:41Z | |
dc.date.issued | 2017-12-13 | |
dc.identifier.citation | Cell Host Microbe. 2017; 22(6):733-745 | es_ES |
dc.identifier.issn | 1931-3128 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/7310 | |
dc.description.abstract | Interactions between the host and its microbiota are of mutual benefit and promote health. Complex molecular pathways underlie this dialog, but the identity of microbe-derived molecules that mediate the mutualistic state remains elusive. Helicobacter hepaticus is a member of the mouse intestinal microbiota that is tolerated by the host. In the absence of an intact IL-10 signaling, H. hepaticus induces an IL-23-driven inflammatory response in the intestine. Here we investigate the interactions between H. hepaticus and host immune cells that may promote mutualism, and the microbe-derived molecule(s) involved. Our results show that H. hepaticus triggers early IL-10 induction in intestinal macrophages and produces a large soluble polysaccharide that activates a specific MSK/CREB-dependent anti-inflammatory and repair gene signature via the receptor TLR2. These data identify a host-bacterial interaction that promotes mutualistic mechanisms at the intestinal interface. Further understanding of this pathway may provide novel prevention and treatment strategies for inflammatory bowel disease. | es_ES |
dc.description.sponsorship | We thank the High-Throughput Genomics Group at the Wellcome Trust Centre for Human Genetics for the generation of the Sequencing data. F.F. was supported by Cancer Research UK (OCRC-DPhil13-FF) and N.E.I. by the Kennedy Trust (KENN 15 16 03). M.M.-L. received a fellowship from the Spanish Ministry of Education, Culture, and Sport. This work was funded by the Wellcome Trust UK (095688/Z/11/Z), an ERC grant (Advanced Grant Ares(2013)3687660), and the Fondation Louis Jeantet | es_ES |
dc.language.iso | eng | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | CREB | es_ES |
dc.subject | Helicobacter hepaticus | es_ES |
dc.subject | MSK1/2 | es_ES |
dc.subject | TLR2 | es_ES |
dc.subject | Anti-inflammatory gene signature | es_ES |
dc.subject | Host-microbe interactions | es_ES |
dc.subject | Inflammatory bowel disease | es_ES |
dc.subject | Macrophage | es_ES |
dc.subject | Mutualism | es_ES |
dc.subject | Polysaccharide | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Helicobacter hepaticus | es_ES |
dc.subject.mesh | Immunosuppressive Agents | es_ES |
dc.subject.mesh | Interleukin-10 | es_ES |
dc.subject.mesh | Interleukin-23 | es_ES |
dc.subject.mesh | Macrophages | es_ES |
dc.subject.mesh | Mice | es_ES |
dc.subject.mesh | Polysaccharides, Bacterial | es_ES |
dc.subject.mesh | Toll-Like Receptor 2 | es_ES |
dc.subject.mesh | Symbiosis | es_ES |
dc.title | A Large Polysaccharide Produced by Helicobacter hepaticus Induces an Anti-inflammatory Gene Signature in Macrophages | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 29241040 | es_ES |
dc.format.volume | 22 | es_ES |
dc.format.number | 6 | es_ES |
dc.format.page | 733-745.e5 | es_ES |
dc.identifier.doi | 10.1016/j.chom.2017.11.002 | es_ES |
dc.contributor.funder | Ministerio de Educación y Ciencia (España) | |
dc.contributor.funder | Wellcome Trust | |
dc.contributor.funder | Kennedy Trust | |
dc.contributor.funder | Foundation Lous Jeantet | |
dc.contributor.funder | Unión Europea. Comisión Europea | |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1934-6069 | es_ES |
dc.identifier.journal | Cell host & microbe | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Inmunobiología | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |