Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/7303
Título
Mitochondria Know No Boundaries: Mechanisms and Functions of Intercellular Mitochondrial Transfer
Autor(es)
Fecha de publicación
2016
Cita
Front Cell Dev Biol. 2016; 4:107
Idioma
Inglés
Tipo de documento
journal article
Resumen
Mitochondria regulate multiple cell processes, including calcium signaling, apoptosis and cell metabolism. Mitochondria contain their own circular genome encoding selected subunits of the oxidative phosphorylation complexes. Recent findings reveal that, in addition to being maternally inherited, mitochondria can traverse cell boundaries and thus be horizontally transferred between cells. Although, the physiological relevance of this phenomenon is still under debate, mitochondria uptake rescues mitochondrial respiration defects in recipient cells and regulates signaling, proliferation or chemotherapy resistance in vitro and in vivo. In this review, we outline the pathophysiological consequences of horizontal mitochondrial transfer and offer a perspective on the cellular and molecular mechanisms mediating their intercellular transmission, including tunneling nanotubes, extracellular vesicles, cellular fusion, and GAP junctions. The physiological relevance of mitochondrial transfer and the potential therapeutic application of this exchange for treating mitochondrial-related diseases are discussed.
Palabras clave
DAMPs | Communication | Exosomes | Extracellular vesicles | Horizontal genetic transfer | Inflammation | Mitochondrial diseases | Tunneling nanotubes
Versión en línea
DOI
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