dc.contributor.author | Martinez-Lopez, Maria | |
dc.contributor.author | Iborra, Salvador | |
dc.contributor.author | Conde-Garrosa, Ruth | |
dc.contributor.author | Mastrangelo, Annalaura | |
dc.contributor.author | Danne, Camille | |
dc.contributor.author | Mann, Elizabeth R | |
dc.contributor.author | Reid, Delyth M | |
dc.contributor.author | Gaboriau-Routhiau, Valérie | |
dc.contributor.author | Chaparro, Maria | |
dc.contributor.author | Lorenzo, María P | |
dc.contributor.author | Minnerup, Lara | |
dc.contributor.author | Saz-Leal, Paula | |
dc.contributor.author | Slack, Emma | |
dc.contributor.author | Kemp, Benjamin | |
dc.contributor.author | Gisbert, Javier P | |
dc.contributor.author | Dzionek, Andrzej | |
dc.contributor.author | Robinson, Matthew J | |
dc.contributor.author | Rupérez, Francisco J | |
dc.contributor.author | Cerf-Bensussan, Nadine | |
dc.contributor.author | Brown, Gordon D | |
dc.contributor.author | Bernardo, David | |
dc.contributor.author | LeibundGut-Landmann, Salomé | |
dc.contributor.author | Sancho, David | |
dc.date.accessioned | 2019-03-07T09:39:03Z | |
dc.date.available | 2019-03-07T09:39:03Z | |
dc.date.issued | 2019-02-19 | |
dc.identifier.citation | Immunity. 2019; 50(2):446-461 | es_ES |
dc.identifier.issn | 10747613 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/7296 | |
dc.description.abstract | Production of interleukin-17 (IL-17) and IL-22 by T helper 17 (Th17) cells and group 3 innate lymphoid cells (ILC3s) in response to the gut microbiota ensures maintenance of intestinal barrier function. Here, we examined the mechanisms whereby the immune system detects microbiota in the steady state. A Syk-kinase-coupled signaling pathway in dendritic cells (DCs) was critical for commensal-dependent production of IL-17 and IL-22 by CD4+ T cells. The Syk-coupled C-type lectin receptor Mincle detected mucosal-resident commensals in the Peyer's patches (PPs), triggered IL-6 and IL-23p19 expression, and thereby regulated function of intestinal Th17- and IL-17-secreting ILCs. Mice deficient in Mincle or with selective depletion of Syk in CD11c+ cells had impaired production of intestinal RegIIIγ and IgA and increased systemic translocation of gut microbiota. Consequently, Mincle deficiency led to liver inflammation and deregulated lipid metabolism. Thus, sensing of commensals by Mincle and Syk signaling in CD11c+ cells reinforces intestinal immune barrier and promotes host-microbiota mutualism, preventing systemic inflammation. | es_ES |
dc.description.sponsorship | M.M.-L. received a Formacion de Personal Universitario (FPU) fellowship (AP2010-5935) from the Spanish Ministerio de Educacion. S.I. is funded by grant SAF2015-74561-JIN from the Spanish Ministerio de Ciencia, Innovacion, y Universidades (MCIU) and Fondos Europeos de Desarrollo Regional (FEDER). G.D.B and D.M.R. are supported by the Wellcome Trust and the MRC Centre for Medical Mycology at the University of Aberdeen. S.L.L. is supported by the Swiss National Science Foundation (PP00P3_150758). Work in the D.S. laboratory is funded by the CNIC and grant SAF2016-79040-R from MCIU, the Agencia Estatal de Investigacion, and FEDER; B2017/BMD-3733 Immunothercan-CM from Comunidad de Madrid; RD16/0015/0018-REEM from FIS-Instituto de Salud Carlos III, MCIU, and FEDER; the Acteria Foundation; the Constantes y Vitales prize (Atresmedia); La Maratode TV3 Foundation (201723); the European Commission (635122-PROCROP H2020), and the European Research Council (ERC-2016-Consolidator Grant 725091). The CNIC is supported by the MCIU and the Pro-CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | IL-17 | es_ES |
dc.subject | IL-22 | es_ES |
dc.subject | Mincle | es_ES |
dc.subject | Syk kinase | es_ES |
dc.subject | T lymphocyte | es_ES |
dc.subject | antimicrobial defense | es_ES |
dc.subject | Dendritic cell | es_ES |
dc.subject | Gut microbiota translocation | es_ES |
dc.subject | Innate lymphoid cells | es_ES |
dc.subject | Intestinal barrier | es_ES |
dc.subject | Lipid metabolism | es_ES |
dc.subject | Liver inflammation | es_ES |
dc.title | Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 30709742 | es_ES |
dc.format.volume | 50 | es_ES |
dc.format.number | 2 | es_ES |
dc.format.page | 446-461.e9 | es_ES |
dc.identifier.doi | 10.1016/j.immuni.2018.12.020 | es_ES |
dc.contributor.funder | Ministerio de Educación y Ciencia (España) | |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Wellcome Trust | |
dc.contributor.funder | University of Aberdeen (Reino Unido) | |
dc.contributor.funder | Swiss National Science Foundation | |
dc.contributor.funder | Centro Nacional de Investigaciones Cardiovasculares Carlos III (España) | |
dc.contributor.funder | Fondation ACTERIA (Acting on European Research in Immunology and Allergology) | |
dc.contributor.funder | Atresmedia | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.contributor.funder | Fundación La Marató TV3 | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Fundación ProCNIC | |
dc.contributor.funder | Unión Europea. Comisión Europea | |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1097-4180 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.immuni.2018.12.020 | es_ES |
dc.identifier.journal | Immunity | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Inmunobiología | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/635122 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/725091 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/AP2010-5935 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2015-74561-JIN | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2016-79040-R | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD16/0015/0018-REEM | es_ES |
dc.rights.accessRights | open access | es_ES |