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dc.contributor.authorFernández-Barahona, Irene
dc.contributor.authorGutiérrez, Lucía
dc.contributor.authorVeintemillas-Verdaguer, Sabino
dc.contributor.authorPellico, Juan 
dc.contributor.authorMorales, María del Puerto
dc.contributor.authorCatala-Montoro, Mauro 
dc.contributor.authordel Pozo, Miguel Angel 
dc.contributor.authorRuiz-Cabello, Jesús 
dc.contributor.authorHerranz, Fernando
dc.identifier.citationACS Omega. 2019; 4(2):2719-2727es_ES
dc.description.abstractSynthesizing iron oxide nanoparticles for positive contrast in magnetic resonance imaging is the most promising approach to bring this nanomaterial back to the clinical field. The success of this approach depends on several aspects: the longitudinal relaxivity values, the complexity of the synthetic protocol, and the reproducibility of the synthesis. Here, we show our latest results on this goal. We have studied the effect of Cu doping on the physicochemical, magnetic, and relaxometric properties of iron oxide nanoparticles designed to provide positive contrast in magnetic resonance imaging. We have used a one-step, 10 min synthesis to produce nanoparticles with excellent colloidal stability. We have synthesized three different Cu-doped iron oxide nanoparticles showing modest to very large longitudinal relaxivity values. Finally, we have demonstrated the in vivo use of these kinds of nanoparticles both in angiography and targeted molecular imaging.es_ES
dc.description.sponsorshipThis study was supported by grants from the Spanish Ministry for Economy and Competitiveness (MEyC) (SAF2016-79593-P, MAT2017-88148-R, and SAF2017-84494-C2-R), Comunidad de Madrid (S2017/BMD-3875), and Instituto de Salud Carlos III (DTS16/00059). L.G. received financial support from the Ramoń y Cajal subprogram (RYC-2014-15512). J.R.-C. acknowledges funding from the Programa Red Guipuzcoana de Ciencia, Tecnología e Información (2018-CIEN-000058-01). I.F.-B. thanks Comunidad de Madrid (B2017/BMD-3875). This work was performed under the Maria de Maeztu Units of Excellence Program from the Spanish State Research Agency (Grant No. MDM-2017-0720).es_ES
dc.publisherAmerican Chemical Society (ACS) es_ES
dc.titleCu-Doped Extremely Small Iron Oxide Nanoparticles with Large Longitudinal Relaxivity: One-Pot Synthesis and in Vivo Targeted Molecular Imaginges_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.contributor.funderComunidad de Madrid 
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderRed Guipuzcoana de Ciencia, Tecnología e Información
dc.identifier.journalACS Omegaes_ES
dc.repisalud.orgCNICCNIC::Unidades técnicases_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Señalización por Integrinases_ES
dc.rights.accessRightsopen accesses_ES

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Atribución 4.0 Internacional
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