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dc.contributor.authorCruz-Adalia, Aránzazu
dc.contributor.authorRamirez-Santiago, Guillermo
dc.contributor.authorOsuna-Pérez, Jesús
dc.contributor.authorTorres-Torresano, Mónica
dc.contributor.authorZorita, Virginia 
dc.contributor.authorMartínez-Riaño, Ana
dc.contributor.authorBoccasavia, Viola
dc.contributor.authorBorroto, Aldo
dc.contributor.authorMartinez del Hoyo, Gloria 
dc.contributor.authorGonzalez-Granado, Jose Maria 
dc.contributor.authorAlarcón, Balbino
dc.contributor.authorSanchez-Madrid, Francisco 
dc.contributor.authorVeiga, Esteban
dc.date.accessioned2019-02-25T11:39:15Z
dc.date.available2019-02-25T11:39:15Z
dc.date.issued2017
dc.identifier.citationNat Commun. 2017; 8(1):1591es_ES
dc.identifier.issn2041-1723es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7229
dc.description.abstractBacterial phagocytosis and antigen cross-presentation to activate CD8+ T cells are principal functions of professional antigen presenting cells. However, conventional CD4+ T cells also capture and kill bacteria from infected dendritic cells in a process termed transphagocytosis (also known as transinfection). Here, we show that transphagocytic T cells present bacterial antigens to naive CD8+ T cells, which proliferate and become cytotoxic in response. CD4+ T-cell-mediated antigen presentation also occurs in vivo in the course of infection, and induces the generation of central memory CD8+ T cells with low PD-1 expression. Moreover, transphagocytic CD4+ T cells induce protective anti-tumour immune responses by priming CD8+ T cells, highlighting the potential of CD4+ T cells as a tool for cancer immunotherapy.es_ES
dc.description.sponsorshipJ.M.G.-G. is supported by the Miguel Servet Program (Instituto de Salud Carlos III; ISCIII) and V.Z. by the ISCIII. This work was supported by grants from the Spanish Ministries of Science and Technology (MICINN; BFU2011-29450 to E.V.) and of Economy and Competitiveness (MINECO; SAF201456716-REDT and BFU2014-59585-R to E.V., SAF2014-55579-R to F.S.M., SAF201347975-R to B.A., SAF2014-58895-JIN to A.C.-A.), the ISCIII (PI14/00526; CP11/00145; CPII16/00022 to J.M.G.-G.), the Fundación Ramón Areces (to J.M.G.-G.), the Madrid regional government (INDISNET-S2011/BMD-2332 to F.S.M.) and the European Research Council (ERC-2011-AdG 294340-GENTRIS to F.S.M.; ERC 2013-AdG 334763 NOVARIPP to B.A.). F.S.M. and J.M.G.-G. are also financed by CIBER Cardiovascular, Spain.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/*
dc.subject.meshAnimals es_ES
dc.subject.meshAntigen Presentation es_ES
dc.subject.meshAntigens, Bacterial es_ES
dc.subject.meshCD4-Positive T-Lymphocytes es_ES
dc.subject.meshCD8-Positive T-Lymphocytes es_ES
dc.subject.meshCells, Cultured es_ES
dc.subject.meshCross-Priming es_ES
dc.subject.meshCytotoxicity, Immunologic es_ES
dc.subject.meshImmunologic Memory es_ES
dc.subject.meshImmunological Synapses es_ES
dc.subject.meshMice, Inbred C57BL es_ES
dc.subject.meshMice, Transgenic es_ES
dc.subject.meshPhagocytosis es_ES
dc.subject.meshProgrammed Cell Death 1 Receptor es_ES
dc.titleConventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responseses_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID29147022es_ES
dc.format.volume8es_ES
dc.format.number1es_ES
dc.format.page1591es_ES
dc.identifier.doi10.1038/s41467-017-01661-7es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderComunidad de Madrides_ES
dc.contributor.funderFundación Ramón Areceses_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderEuropean Research Counciles_ES
dc.contributor.funderCentro de Investigación Biomedica en Red - CIBERes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2041-1723es_ES
dc.relation.publisherversionhttps://doi.org/10.1038/s41467-017-01661-7es_ES
dc.identifier.journalNature communicationses_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Comunicación Intercelular en la Respuesta Inflamatoriaes_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/294340/EUes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/334763/EUes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BFU2011-29450es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2014-56716-REDTes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BFU2014-59585-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2014-55579-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2014-58895-JINes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2013-47975-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14/00526es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CP11/00145es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CPII16/00022es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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