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dc.contributor.author | Cruz-Adalia, Aránzazu | |
dc.contributor.author | Ramirez-Santiago, Guillermo | |
dc.contributor.author | Osuna-Pérez, Jesús | |
dc.contributor.author | Torres-Torresano, Mónica | |
dc.contributor.author | Zorita, Virginia | |
dc.contributor.author | Martínez-Riaño, Ana | |
dc.contributor.author | Boccasavia, Viola | |
dc.contributor.author | Borroto, Aldo | |
dc.contributor.author | Martinez del Hoyo, Gloria | |
dc.contributor.author | Gonzalez-Granado, Jose Maria | |
dc.contributor.author | Alarcón, Balbino | |
dc.contributor.author | Sanchez-Madrid, Francisco | |
dc.contributor.author | Veiga, Esteban | |
dc.date.accessioned | 2019-02-25T11:39:15Z | |
dc.date.available | 2019-02-25T11:39:15Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Nat Commun. 2017; 8(1):1591 | es_ES |
dc.identifier.issn | 2041-1723 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/7229 | |
dc.description.abstract | Bacterial phagocytosis and antigen cross-presentation to activate CD8+ T cells are principal functions of professional antigen presenting cells. However, conventional CD4+ T cells also capture and kill bacteria from infected dendritic cells in a process termed transphagocytosis (also known as transinfection). Here, we show that transphagocytic T cells present bacterial antigens to naive CD8+ T cells, which proliferate and become cytotoxic in response. CD4+ T-cell-mediated antigen presentation also occurs in vivo in the course of infection, and induces the generation of central memory CD8+ T cells with low PD-1 expression. Moreover, transphagocytic CD4+ T cells induce protective anti-tumour immune responses by priming CD8+ T cells, highlighting the potential of CD4+ T cells as a tool for cancer immunotherapy. | es_ES |
dc.description.sponsorship | J.M.G.-G. is supported by the Miguel Servet Program (Instituto de Salud Carlos III; ISCIII) and V.Z. by the ISCIII. This work was supported by grants from the Spanish Ministries of Science and Technology (MICINN; BFU2011-29450 to E.V.) and of Economy and Competitiveness (MINECO; SAF201456716-REDT and BFU2014-59585-R to E.V., SAF2014-55579-R to F.S.M., SAF201347975-R to B.A., SAF2014-58895-JIN to A.C.-A.), the ISCIII (PI14/00526; CP11/00145; CPII16/00022 to J.M.G.-G.), the Fundación Ramón Areces (to J.M.G.-G.), the Madrid regional government (INDISNET-S2011/BMD-2332 to F.S.M.) and the European Research Council (ERC-2011-AdG 294340-GENTRIS to F.S.M.; ERC 2013-AdG 334763 NOVARIPP to B.A.). F.S.M. and J.M.G.-G. are also financed by CIBER Cardiovascular, Spain. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | * |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Antigen Presentation | es_ES |
dc.subject.mesh | Antigens, Bacterial | es_ES |
dc.subject.mesh | CD4-Positive T-Lymphocytes | es_ES |
dc.subject.mesh | CD8-Positive T-Lymphocytes | es_ES |
dc.subject.mesh | Cells, Cultured | es_ES |
dc.subject.mesh | Cross-Priming | es_ES |
dc.subject.mesh | Cytotoxicity, Immunologic | es_ES |
dc.subject.mesh | Immunologic Memory | es_ES |
dc.subject.mesh | Immunological Synapses | es_ES |
dc.subject.mesh | Mice, Inbred C57BL | es_ES |
dc.subject.mesh | Mice, Transgenic | es_ES |
dc.subject.mesh | Phagocytosis | es_ES |
dc.subject.mesh | Programmed Cell Death 1 Receptor | es_ES |
dc.title | Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-CompartirIgual 4.0 Internacional | * |
dc.identifier.pubmedID | 29147022 | es_ES |
dc.format.volume | 8 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 1591 | es_ES |
dc.identifier.doi | 10.1038/s41467-017-01661-7 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.contributor.funder | Fundación Ramón Areces | |
dc.contributor.funder | Unión Europea. Comisión Europea | |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | |
dc.contributor.funder | Centro de Investigación Biomedica en Red - CIBER | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2041-1723 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1038/s41467-017-01661-7 | es_ES |
dc.identifier.journal | Nature communications | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Comunicación Intercelular en la Respuesta Inflamatoria | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/294340/EU | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/334763/EU | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/BFU2011-29450 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2014-56716-REDT | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/BFU2014-59585-R | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2014-55579-R | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2014-58895-JIN | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2013-47975-R | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/00526 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/CP11/00145 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/CPII16/00022 | es_ES |
dc.rights.accessRights | open access | es_ES |