Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/7217
Data on administration of cyclosporine, nicorandil, metoprolol on reperfusion related outcomes in ST-segment Elevation Myocardial Infarction treated with percutaneous coronary intervention
Campo, Gianluca | Pavasini, Rita | Morciano, Giampaolo | Lincoff, Michael A | C Gibson, Michael | Kitakaze, Masafumi | Lonborg, Jacob | Ahluwalia, Amrita | Ishii, Hideki | Frenneaux, Michael | Ovize, Michel | Galvani, Marcello | Atar, Dan | Ibanez, Borja CNIC | Cerisano, Giampaolo | Biscaglia, Simone | Neil, Brandon J | Asakura, Masanori | Engstrom, Thomas | Jones, Daniel A | Dawson, Dana | Ferrari, Roberto | Pinton, Paolo | Ottani, Filippo
Data Brief. 2017; 14:197-205
Mortality and morbidity in patients with ST elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) are still high . A huge amount of the myocardial damage is related to the mitochondrial events happening during reperfusion . Several drugs directly and indirectly targeting mitochondria have been administered at the time of the PCI and their effect on fatal (all-cause mortality, cardiovascular (CV) death) and non fatal (hospital readmission for heart failure (HF)) outcomes have been tested showing conflicting results , , , , , , , , , , , , , . Data from 15 trials have been pooled with the aim to analyze the effect of drug administration versus placebo on outcome . Subgroup analysis are here analyzed: considering only randomized clinical trial (RCT) on cyclosporine or nicorandil , , , , , , excluding a trial on metoprolol  and comparing trial with follow-up length <12 months versus those with longer follow-up , , , , , , , , , , , , , . This article describes data related article titled "Clinical Benefit of Drugs Targeting Mitochondrial Function as an Adjunct to Reperfusion in ST-segment Elevation Myocardial Infarction: a Meta-Analysis of Randomized Clinical Trials" .
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