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dc.contributor.authorCorella, Dolores
dc.contributor.authorColtell, Oscar
dc.contributor.authorPortolés, Olga
dc.contributor.authorSotos-Prieto, Mercedes 
dc.contributor.authorFernández-Carrión, Rebeca
dc.contributor.authorRamirez-Sabio, Judith B
dc.contributor.authorZanón-Moreno, Vicente
dc.contributor.authorMattei, Josiemer
dc.contributor.authorSorlí, José V
dc.contributor.authorOrdovas, Jose M 
dc.date.accessioned2019-02-21T10:30:08Z
dc.date.available2019-02-21T10:30:08Z
dc.date.issued2018-12-20
dc.identifier.citationNutrients. 2018; 11(1):4es_ES
dc.identifier.issn2072-6643es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7207
dc.description.abstractPrecision nutrition aims to make dietary recommendations of a more personalized nature possible, to optimize the prevention or delay of a disease and to improve health. Therefore, the characteristics (including sex) of an individual have to be taken into account as well as a series of omics markers. The results of nutritional genomics studies are crucial to generate the evidence needed so that precision nutrition can be applied. Although sex is one of the fundamental variables for making recommendations, at present, the nutritional genomics studies undertaken have not analyzed, systematically and with a gender perspective, the heterogeneity/homogeneity in gene-diet interactions on the different phenotypes studied, thus there is little information available on this issue and needs to be improved. Here we argue for the need to incorporate the gender perspective in nutritional genomics studies, present the general context, analyze the differences between sex and gender, as well as the limitations to measuring them and to detecting specific sex-gene or sex-phenotype associations, both at the specific gene level or in genome-wide-association studies. We analyzed the main sex-specific gene-diet interactions published to date and their main limitations and present guidelines with recommendations to be followed when undertaking new nutritional genomics studies incorporating the gender perspective.es_ES
dc.description.sponsorshipThis study was partially funded by the Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (FEDER) (grants CIBER 06/03, PRX17/00500, PI16/00366, PI06/1326, and SAF2016–80532-R); the University Jaume I (grants P1–1B2013–54 and COGRUP/2016/06); the Fundació La Marató de TV3 (grant 538/U/2016); the Real Colegio Complutense at Harvard University, the Generalitat Valenciana (grant PROMETEO2017/017 and AEST/2018/044) and by the US Department of Agriculture, Agriculture Research Service (8050–51000-098-00D).es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectdietes_ES
dc.subjectgenderes_ES
dc.subjectnutrigenomicses_ES
dc.subjectnutritional genomicses_ES
dc.subjectprecision nutritiones_ES
dc.subjectsexes_ES
dc.subject.meshDiet es_ES
dc.subject.meshFemale es_ES
dc.subject.meshGender Identity es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMale es_ES
dc.subject.meshNutrigenomics es_ES
dc.subject.meshNutritional Physiological Phenomena es_ES
dc.subject.meshNutritional Status es_ES
dc.subject.meshPhenotype es_ES
dc.subject.meshPrecision Medicine es_ES
dc.subject.meshSex Characteristics es_ES
dc.subject.meshSex Factors es_ES
dc.titleA Guide to Applying the Sex-Gender Perspective to Nutritional Genomicses_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID30577445es_ES
dc.format.volume11es_ES
dc.format.number1es_ES
dc.format.page4es_ES
dc.identifier.doi10.3390/nu11010004es_ES
dc.contributor.funderMinisterio de Sanidad, Consumo y Bienestar Social (España)es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderFundacio La Maratoes_ES
dc.contributor.funderGeneralitat Valencianaes_ES
dc.contributor.funderUniversidad Jaume Ies_ES
dc.contributor.funderDepartment of Agriculture (United States)es_ES
dc.contributor.funderCentro de Investigación Biomedica en Red - CIBERes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2072-6643es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/nu11010004es_ES
dc.identifier.journalNutrientses_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionaleses_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PRX17/00500es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI16/00366es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI06/1326es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2016-80532-Res_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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