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dc.contributor.author | Corella, Dolores | |
dc.contributor.author | Coltell, Oscar | |
dc.contributor.author | Portolés, Olga | |
dc.contributor.author | Sotos-Prieto, Mercedes | |
dc.contributor.author | Fernández-Carrión, Rebeca | |
dc.contributor.author | Ramirez-Sabio, Judith B | |
dc.contributor.author | Zanón-Moreno, Vicente | |
dc.contributor.author | Mattei, Josiemer | |
dc.contributor.author | Sorlí, José V | |
dc.contributor.author | Ordovas, Jose M | |
dc.date.accessioned | 2019-02-21T10:30:08Z | |
dc.date.available | 2019-02-21T10:30:08Z | |
dc.date.issued | 2018-12-20 | |
dc.identifier.citation | Nutrients. 2018; 11(1):4 | es_ES |
dc.identifier.issn | 2072-6643 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/7207 | |
dc.description.abstract | Precision nutrition aims to make dietary recommendations of a more personalized nature possible, to optimize the prevention or delay of a disease and to improve health. Therefore, the characteristics (including sex) of an individual have to be taken into account as well as a series of omics markers. The results of nutritional genomics studies are crucial to generate the evidence needed so that precision nutrition can be applied. Although sex is one of the fundamental variables for making recommendations, at present, the nutritional genomics studies undertaken have not analyzed, systematically and with a gender perspective, the heterogeneity/homogeneity in gene-diet interactions on the different phenotypes studied, thus there is little information available on this issue and needs to be improved. Here we argue for the need to incorporate the gender perspective in nutritional genomics studies, present the general context, analyze the differences between sex and gender, as well as the limitations to measuring them and to detecting specific sex-gene or sex-phenotype associations, both at the specific gene level or in genome-wide-association studies. We analyzed the main sex-specific gene-diet interactions published to date and their main limitations and present guidelines with recommendations to be followed when undertaking new nutritional genomics studies incorporating the gender perspective. | es_ES |
dc.description.sponsorship | This study was partially funded by the Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (FEDER) (grants CIBER 06/03, PRX17/00500, PI16/00366, PI06/1326, and SAF2016–80532-R); the University Jaume I (grants P1–1B2013–54 and COGRUP/2016/06); the Fundació La Marató de TV3 (grant 538/U/2016); the Real Colegio Complutense at Harvard University, the Generalitat Valenciana (grant PROMETEO2017/017 and AEST/2018/044) and by the US Department of Agriculture, Agriculture Research Service (8050–51000-098-00D). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Diet | es_ES |
dc.subject | Gender | es_ES |
dc.subject | Nutrigenomics | es_ES |
dc.subject | Nutritional genomics | es_ES |
dc.subject | Precision nutrition | es_ES |
dc.subject | Sex | es_ES |
dc.subject.mesh | Diet | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Gender Identity | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Nutrigenomics | es_ES |
dc.subject.mesh | Nutritional Physiological Phenomena | es_ES |
dc.subject.mesh | Nutritional Status | es_ES |
dc.subject.mesh | Phenotype | es_ES |
dc.subject.mesh | Precision Medicine | es_ES |
dc.subject.mesh | Sex Characteristics | es_ES |
dc.subject.mesh | Sex Factors | es_ES |
dc.title | A Guide to Applying the Sex-Gender Perspective to Nutritional Genomics | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 30577445 | es_ES |
dc.format.volume | 11 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 4 | es_ES |
dc.identifier.doi | 10.3390/nu11010004 | es_ES |
dc.contributor.funder | Ministerio de Sanidad, Consumo y Bienestar Social (España) | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Fundación La Marató TV3 | |
dc.contributor.funder | Generalitat Valenciana (España) | |
dc.contributor.funder | Jaume I University (España) | |
dc.contributor.funder | United States Department of Agriculture | |
dc.contributor.funder | Centro de Investigación Biomedica en Red - CIBER | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2072-6643 | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/nu11010004 | es_ES |
dc.identifier.journal | Nutrients | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionales | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PRX17/00500 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI16/00366 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI06/1326 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2016-80532-R | es_ES |
dc.rights.accessRights | open access | es_ES |