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dc.contributor.authorGomez-Serrano, Maria 
dc.contributor.authorCamafeita, Emilio 
dc.contributor.authorLoureiro, Marta 
dc.contributor.authorPeral, Belén
dc.identifier.citationOxid Med Cell Longev. 2018; 2018:1435934es_ES
dc.description.abstractMitochondria are highly dynamic and regulated organelles that historically have been defined based on their crucial role in cell metabolism. However, they are implicated in a variety of other important functions, making mitochondrial dysfunction an important axis in several pathological contexts. Despite that conventional biochemical and molecular biology approaches have provided significant insight into mitochondrial functionality, innovative techniques that provide a global view of the mitochondrion are still necessary. Proteomics fulfils this need by enabling accurate, systems-wide quantitative analysis of protein abundance. More importantly, redox proteomics approaches offer unique opportunities to tackle oxidative stress, a phenomenon that is intimately linked to aging, cardiovascular disease, and cancer. In addition, cutting-edge proteomics approaches reveal how proteins exert their functions in complex interaction networks where even subtle alterations stemming from early pathological states can be monitored. Here, we describe the proteomics approaches that will help to deepen the role of mitochondria in health and disease by assessing not only changes to mitochondrial protein composition but also alterations to their redox state and how protein interaction networks regulate mitochondrial function and dynamics. This review is aimed at showing the reader how the application of proteomics approaches during the last 20 years has revealed crucial mitochondrial roles in the context of aging, neurodegenerative disorders, metabolic disease, and cancer.es_ES
dc.description.sponsorshipThe proteomic data supporting this systematic review are from previously reported studies and datasets, which have been cited throughout the text. This work was supported by grant SAF2012-33014 from the Ministry of Economy, Industry and Competitiveness (MEIC), Spain, and partially financed with FEDER funds (to B.P.). CNIC is supported by the Ministerio de Ciencia, Innovación y Universidades, and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505).es_ES
dc.publisherHindawi es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMitochondria es_ES
dc.subject.meshOxidation-Reduction es_ES
dc.subject.meshOxidative Stress es_ES
dc.subject.meshProteomics es_ES
dc.titleMitoproteomics: Tackling Mitochondrial Dysfunction in Human Diseasees_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España) 
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España) 
dc.contributor.funderFundación ProCNIC 
dc.identifier.journalOxidative medicine and cellular longevityes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Proteómica cardiovasculares_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Proteómica / Metabolómicaes_ES
dc.rights.accessRightsopen accesses_ES

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Atribución 4.0 Internacional
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