Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/6693
Título
Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration
Autor(es)
Sanchez-Iranzo, Hector CNIC | Galardi-Castilla, Maria CNIC | Minguillon, Carolina | Sanz-Morejon, Andres CNIC | Gonzalez-Rosa, Juan Manuel CNIC | Felker, Anastasia | Ernst, Alexander | Guzman-Martinez, Gabriela CNIC | Mosimann, Christian | Mercader, Nadia CNIC
Fecha de publicación
2018
Cita
Nat Commun. 2018; 9(1):428
Idioma
Inglés
Tipo de documento
journal article
Resumen
During development, mesodermal progenitors from the first heart field (FHF) form a primitive cardiac tube, to which progenitors from the second heart field (SHF) are added. The contribution of FHF and SHF progenitors to the adult zebrafish heart has not been studied to date. Here we find, using genetic tbx5a lineage tracing tools, that the ventricular myocardium in the adult zebrafish is mainly derived from tbx5a(+) cells, with a small contribution from tbx5a(+) SHF progenitors. Notably, ablation of ventricular tbx5a(+)-derived cardiomyocytes in the embryo is compensated by expansion of SHF-derived cells. In the adult, tbx5a expression is restricted to the trabeculae and excluded from the outer cortical layer. tbx5a-lineage tracing revealed that trabecular cardiomyocytes can switch their fate and differentiate into cortical myocardium during adult heart regeneration. We conclude that a high degree of cardiomyocyte cell fate plasticity contributes to efficient regeneration.
Versión en línea
DOI
Aparece en las colecciones
Ficheros en el ítem
![Acceso Abierto Acceso Abierto](/themes/Mirage2/images/openAccess.png)
- Nombre:
- Tbx5aLineageTracingShows_2018_ ...
- Tamaño:
- 16.06Kb
- Formato:
- Microsoft Word 2007
![Acceso Abierto Acceso Abierto](/themes/Mirage2/images/openAccess.png)
- Nombre:
- Tbx5aLineageTracingShows_2018_ ...
- Tamaño:
- 1.532Mb
- Formato:
- Microsoft Excel 2007