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dc.contributor.authorHalcox, Julian P. J.
dc.contributor.authorRoy, Carine
dc.contributor.authorTubach, Florence
dc.contributor.authorBanegas, José Ramón
dc.contributor.authorDallongeville, Jean
dc.contributor.authorDe Backer, Guy
dc.contributor.authorGuallar, Eliseo 
dc.contributor.authorSazova, Oguen
dc.contributor.authorMedina, Jesus
dc.contributor.authorPerk, Joep
dc.contributor.authorSteg, Philippe Gabriel
dc.contributor.authorRodríguez-Artalejo, Fernando
dc.contributor.authorBorghi, Claudio
dc.date.accessioned2018-10-25T08:19:45Z
dc.date.available2018-10-25T08:19:45Z
dc.date.issued2014
dc.identifierISI:000334535900001
dc.identifier.citationBMC Cardiovasc Disord. 2014; 14(1):25
dc.identifier.issn1471-2261
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6516
dc.description.abstractBackground: Elevated C-reactive protein (CRP) levels are associated with high cardiovascular risk, and might identify patients who could benefit from more carefully adapted risk factor management. We have assessed the prevalence of elevated CRP levels in patients with one or more traditional cardiovascular risk factors. Methods: Data were analysed from the European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice (EURIKA, ClinicalTrials. gov Identifier: NCT00882336), which included patients (aged = 50 years) from 12 European countries with at least one traditional cardiovascular risk factor but no history of cardiovascular disease. Analysis was also carried out on the subset of patients without diabetes mellitus who were not receiving statin therapy. Results: In the overall population, CRP levels were positively correlated with body mass index and glycated haemoglobin levels, and were negatively correlated with high- density lipoprotein cholesterol levels. CRP levels were also higher in women, those at higher traditionally estimated cardiovascular risk and those with greater numbers of metabolic syndrome markers. Among patients without diabetes mellitus who were not receiving statin therapy, approximately 30\% had CRP levels >= 3 mg/ L, and approximately 50\% had CRP levels = 2 mg/ L, including those at intermediate levels of traditionally estimated cardiovascular risk. Conclusions: CRP levels are elevated in a large proportion of patients with at least one cardiovascular risk factor, without diabetes mellitus who are not receiving statin therapy, suggesting a higher level of cardiovascular risk than predicted according to conventional risk estimation systems.
dc.description.sponsorshipWriting support was provided by Dr Stephen Sweet from Oxford PharmaGenesis T Ltd, Oxford, UK, and was funded by AstraZeneca. The authors thank Professor Dr Eliseo Guallar, Department of Cardiovascular Epidemiology and Population Genetics, National Center for Cardiovascular Research, Madrid, Spain, who participated as a member of the EURIKA study academic steering committee.
dc.language.isoeng
dc.publisherBiomed Central LTD
dc.relation.isversionofPublisher's version
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectC-reactive protein
dc.subjectCardiovascular disease
dc.subjectEpidemiology
dc.subjectRisk factors/global assessment
dc.subjectCORONARY-HEART-DISEASE
dc.subjectPRIMARY PREVENTION
dc.subjectCLINICAL-PRACTICE
dc.subjectHEALTHY-ADULTS
dc.subjectPREDICTION
dc.subjectWOMEN
dc.subjectINFLAMMATION
dc.subjectPOPULATION
dc.subjectMORTALITY
dc.subjectJUPITER
dc.titleC-reactive protein levels in patients at cardiovascular risk: EURIKA study
dc.typeArtículo
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID24564178
dc.format.volume14
dc.identifier.doi10.1186/1471-2261-14-25
dc.contributor.funderOxford PharmaGenesis
dc.description.peerreviewed
dc.relation.publisherversionhttps://doi.org/10.1186/1471-2261-14-25
dc.identifier.journalBMC Cardiovascular Disorders
dc.repisalud.orgCNICCNIC::Grupos de investigación::Antiguos CNIC
dc.repisalud.institucionCNIC
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución 4.0 Internacional
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