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dc.contributor.authorIborra, Salvador 
dc.contributor.authorSancho, David 
dc.date.accessioned2017-12-01T07:37:26Z
dc.date.available2017-12-01T07:37:26Z
dc.date.issued2015
dc.identifierISI:000346758700003
dc.identifier.citationImmunobiology. 2015; 220(2):175-84
dc.identifier.issn0171-2985
dc.identifier.urihttp://hdl.handle.net/20.500.12105/5520
dc.description.abstractAmong myeloid immune receptors, C-type lectin receptors (CLRs) have a remarkable capacity to sense a variety of self and non-self ligands. The coupling of CLRs to different signal transduction modules is influenced not only by the receptor, but also by the nature, density and architecture of the ligand, which can affect the rate of receptor internalization and trafficking to diverse intracellular compartments. Understanding how the variety of self and non-self ligands triggers differential CLR signalling and function presents a fascinating biological challenge. Non-self ligands usually promote inflammation and immunity, whereas self ligands are frequently involved in communication and tolerance. But pathogens can mimic self-inhibitory signals to escape immune surveillance, and endogenous ligands can contribute to the sensing of pathogens through CLRs. In this review, we survey the complexity and flexibility in functional outcome found in the myeloid CLRs, which is not only based on their differing intracellular motifs, but is also conditioned by the physical nature, affinity and avidity of the ligand. (C) 2014 The Authors. Published by Elsevier GmbH.
dc.description.sponsorshipWe are grateful to members of the Immunobiology of Inflammation laboratory for helpful discussion. We thank Simon Bartlett (CNIC) for editorial assistance. Work in the Immunobiology of Inflammation laboratory is funded by the CNIC and grants from the Spanish Ministry of Economy and Competitiveness (SAF-2010-15120) and the European Research Council (ERC Starting Independent Researcher Grant 2010, ERC-2010-StG 260414). DS is the recipient of a Ramon y Cajal fellowship (RYC-2009-04235) from the Spanish Ministry of Economy and Competitiveness.
dc.language.isoeng
dc.publisherElsevier
dc.relation.isversionofPublisher's version
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectInnate immunity
dc.subjectC-type lectin receptors
dc.subjectMyeloid cells
dc.subjectPATTERN-RECOGNITION RECEPTOR
dc.subjectDENDRITIC CELL-RECEPTOR
dc.subjectINDUCED NEUTROPHIL ACTIVATION
dc.subjectSYK TYROSINE KINASE
dc.subjectDC-SIGN
dc.subjectFCR-GAMMA
dc.subjectINFLAMMATORY RESPONSES
dc.subjectCANDIDA-ALBICANS
dc.subjectIMMUNE-RESPONSES
dc.subjectDECTIN-2 RECOGNITION
dc.titleSignalling versatility following self and non-self sensing by myeloid C-type lectin receptors
dc.typeArtículo
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID25269828
dc.format.volume220
dc.format.page175-184
dc.identifier.doi10.1016/j.imbio.2014.09.013
dc.contributor.funderEuropean Commission
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.contributor.funderEuropean Research Council
dc.description.peerreviewed
dc.relation.publisherversionhttps://doi.org/10.1016/j.imbio.2014.09.013
dc.identifier.journalImmunobiology
dc.repisalud.orgCNICCNIC::Grupos de investigación::Inmunobiología
dc.repisalud.institucionCNIC
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/260414/EUes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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