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dc.contributor.author | Sanchez-Gonzalez, Javier | |
dc.contributor.author | Fernandez-Jimenez, Rodrigo | |
dc.contributor.author | Nothnagel, Nils D. | |
dc.contributor.author | Lopez-Martin, Gonzalo J. | |
dc.contributor.author | Fuster, Valentin | |
dc.contributor.author | Ibáñez, Borja | |
dc.date.accessioned | 2017-12-01T07:37:25Z | |
dc.date.available | 2017-12-01T07:37:25Z | |
dc.date.issued | 2015 | |
dc.identifier | ISI:000349945900004 | |
dc.identifier.citation | J Cardiovasc Magn Reson. 2015; 17(1):116 | |
dc.identifier.issn | 1097-6647 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/5515 | |
dc.description.abstract | Background: In-vivo quantification of cardiac perfusion is of great research and clinical value. The dual-bolus strategy is universally used in clinical protocols but has known limitations. The dual-saturation acquisition strategy has been proposed as a more accurate alternative, but has not been validated across the wide range of perfusion rates encountered clinically. Dual-saturation acquisition also lacks a clinically-applicable procedure for optimizing parameter selection. Here we present a comprehensive validation study of dual-saturation strategy in vitro and in vivo. Methods: The impact of saturation time and profile ordering in acquisitions was systematically analyzed in a phantom consisting of 15 tubes containing different concentrations of contrast agent. In-vivo experiments in healthy pigs were conducted to evaluate the effect of R2{*} on the definition of the arterial input function (AIF) and to evaluate the relationship between R2{*} and R1 variations during first-pass of the contrast agent. Quantification by dual-saturation perfusion was compared with the reference-standard dual-bolus strategy in 11 pigs with different grades of myocardial perfusion. Results: Adequate flow estimation by the dual-saturation strategy is achieved with myocardial tissue saturation times around 100 ms (always < 30 ms of AIF), with the lowest echo time, and following a signal model for contrast conversion that takes into account the residual R2{*} effect and profile ordering. There was a good correlation and agreement between myocardial perfusion quantitation by dual-saturation and dual-bolus techniques (R-2 = 0.92, mean difference of 0.1 ml/min/g; myocardial perfusion ranges between 0.18 and 3.93 ml/min/g). Conclusions: The dual-saturation acquisition strategy produces accurate estimates of absolute myocardial perfusion in vivo. The procedure presented here can be applied with minimal interference in standard clinical procedures. | |
dc.description.sponsorship | This work was supported by a competitive grant from the Ministry of Economy and Competitiveness (MINECO), Fondo Europeo de Desarrollo Regional (FEDER, SAF2013-49663-EXP), Carlos III Institute of Health-Fondo de Investigacion Sanitaria (PI13/01979), and FP7-HEALTH-2009 ``Cardio Repair European Multidisciplinary Initiative (CARE-MI)´´. This study forms part of a Master Research Agreement between CNIC and Philips Healthcare. The Spanish Ministry of Economy and Competitiveness and the Pro-CNIC Foundation support the CNIC. Dr. Fermandez-Jimenez is a recipient of a Rio Hortega fellowship from the Ministry of Economy and Competitiveness through the Instituto de Salud Carlos III; and has received a FICNIC fellowship from the Fundacio Jesus Serra, the Fundacion Interhospitalaria de Investigacion Cardiovascular, and the CNIC. Nils Nothnagel is a P7-PEOPLE-2011-ITN `` Translational Training network on the Cellular and Molecular Bases of Heart Homeostasis and Repair´´ fellow. Dr. Sanchez-Gonzalez is an employee of Philips Healthcare.. B.I is supported by the Red de Investigacion Cardiovascular (RIC) of the Spanish Ministry of Health (RD 12/0042/0054). Simon Bartlett (CNIC) provided English editing. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. | |
dc.language.iso | eng | |
dc.publisher | BioMed Central (BMC) | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Dual saturation acquisition strategy | |
dc.subject | Absolute quantitative cardiac perfusion | |
dc.subject | Cardiovascular magnetic resonance | |
dc.subject | CARDIOVASCULAR MAGNETIC-RESONANCE | |
dc.subject | CORONARY-ARTERY-DISEASE | |
dc.subject | NONINVASIVE DETECTION | |
dc.subject | T1 MEASUREMENTS | |
dc.subject | INPUT FUNCTION | |
dc.subject | DOGS | |
dc.subject | ISCHEMIA/REPERFUSION | |
dc.subject | ENHANCEMENT | |
dc.subject | T2-ASTERISK | |
dc.subject | RELAXATION | |
dc.title | Optimization of dual-saturation single bolus acquisition for quantitative cardiac perfusion and myocardial blood flow maps | |
dc.type | journal article | |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 25880970 | |
dc.format.volume | 17 | |
dc.identifier.doi | 10.1186/s12968-015-0116-2 | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Fundación ProCNIC | |
dc.contributor.funder | Fundación Jesús Serra | |
dc.contributor.funder | Fundación Interhospitalaria de Investigación Cardiovascular | |
dc.contributor.funder | Centro de Investigación Biomédica en Red - CIBERCV (Enfermedades Cardiovasculares) | |
dc.identifier.e-issn | 1532-429X | |
dc.relation.publisherversion | https://doi.org/10.1186/s12968-015-0116-2 | |
dc.identifier.journal | Journal of Cardiovascular Magnetic Resonance | |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovascular | |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionales | |
dc.repisalud.institucion | CNIC | |
dc.relation.projectID | MINECO/ICTI2013-2016/SAF2013-49663-EXP | es_ES |
dc.rights.accessRights | open access | es_ES |