Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/5255
T-1-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis
Nanomaterials. 2015; 5(4):1880-90
Iron oxide nanoparticles have long been studied as a T-2 contrast agent in MRI due to their superparamagnetic behavior. T-1-based positive contrast, being much more favorable for clinical application due to brighter and more accurate signaling is, however, still limited to gadolinium- or manganese-based imaging tools. Though being the only available commercial positive-contrast agents, they lack an efficient argument when it comes to biological toxicity and their circulatory half-life in blood. The need arises to design a biocompatible contrast agent with a scope for easy surface functionalization for long circulation in blood and/or targeted imaging. We hereby propose an extremely fast microwave synthesis for fluorescein-labeled extremely-small iron oxide nanoparticles (fdIONP), in a single step, as a viable tool for cell labeling and T-1-MRI. We demonstrate the capabilities of such an approach through high-quality magnetic resonance angiographic images of mice.
iron oxide nanoparticles | MRI | T-1 contrast | microwave | MRI CONTRAST AGENTS | MAGNETIC NANOPARTICLES | T-1
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