Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/5249
Título
Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis
Autor(es)
Fecha de publicación
2016
Cita
Stem Cells Int. 2016; 2016:3543678
Idioma
Inglés
Tipo de documento
journal article
Resumen
Peritoneal dialysis is a form of renal replacement alternative to the hemodialysis. During this treatment, the peritoneal membrane acts as a permeable barrier for exchange of solutes and water. Continual exposure to dialysis solutions, as well as episodes of peritonitis and hemoperitoneum, can cause acute/chronic inflammation and injury to the peritoneal membrane, which undergoes progressive fibrosis, angiogenesis, and vasculopathy, eventually leading to discontinuation of the peritoneal dialysis. Among the different events controlling this pathological process, epithelial to mesenchymal transition of mesothelial cells plays a main role in the induction of fibrosis and in subsequent functional deterioration of the peritoneal membrane. Here, the main extracellular inducers and cellular players are described. Moreover, signaling pathways acting during this process are elucidated, with emphasis on signals delivered by TGF-beta family members and by Toll-like/IL-1 beta receptors. The understanding of molecular mechanisms underlying fibrosis of the peritoneal membrane has both a basic and a translational relevance, since it may be useful for setup of therapies aimed at counteracting the deterioration as well as restoring the homeostasis of the peritoneal membrane.
Palabras clave
TO-MESENCHYMAL TRANSITION | NEGATIVE FEEDBACK LOOP | GLYCATION END-PRODUCTS | E-CADHERIN EXPRESSION | NF-KAPPA-B | MESOTHELIAL CELLS | DIALYSIS PATIENTS | GROWTH-FACTOR | PULMONARY-FIBROSIS | IN-VIVO
Versión en línea
DOI
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