Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/5218
Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair
Barreiro, Olga CNIC | Cibrian, Danay CNIC | Clemente, Cristina CNIC | Alvarez, David ISCIII | Moreno, Vanessa CNIC | Valiente, Iñigo CNIC | Bernad, Antonio CNIC | Vestweber, Dietmar | Arroyo, Alicia G CNIC | Martin, Pilar CNIC | von Andrian, Ulrich H. | Sanchez Madrid, Francisco CNIC
Heterogeneity and functional specialization among skin-resident macrophages are incompletely understood. In this study, we describe a novel subset of murine dermal perivascular macrophages that extend protrusions across the endothelial junctions in steady-state and capture blood-borne macromolecules. Unlike other skin-resident macrophages that are reconstituted by bone marrow-derived progenitors after a genotoxic insult, these cells are replenished by an extramedullary radio-resistant and UV-sensitive Bmi1(+) progenitor. Furthermore, they possess a distinctive anti-inflammatory transcriptional profile, which cannot be polarized under inflammatory conditions, and are involved in repair and remodeling functions for which other skin-resident macrophages appear dispensable. Based on all their properties, we define these macrophages as Skin Transendothelial Radio-resistant Anti-inflammatory Macrophages (STREAM) and postulate that their preservation is important for skin homeostasis.
CD103(+) DENDRITIC CELLS | RESIDENT MACROPHAGES | IN-VIVO | ACTIVATED MACROPHAGES | EXPRESSION PROFILES | BLOOD-VESSELS | KUPFFER CELLS | LYMPH-NODES | STEM-CELLS | RNA-SEQ