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Título
Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization
Autor(es)
Smith, Caren E. | Coltell, Oscar | Sorli, Jose V. | Estruch, Ramon | Angel Martinez-Gonzalez, Miguel | Salas-Salvado, Jordi | Fito, Montserrat | Aros, Fernando | Dashti, Hassan S. | Lai, Chao Q. | Miro, Leticia | Serra-Majem, Lluis | Gomez-Gracia, Enrique | Fiol, Miquel | Ros, Emilio | Aslibekyan, Stella | Hidalgo, Bertha | Neuhouser, Marian L. | Di, Chongzhi | Tucker, Katherine L. | Arnett, Donna K | Ordovas, Jose M CNIC | Corella, Dolores
Fecha de publicación
2016
Cita
Sci Rep. 2016; 6:33188
Idioma
Inglés
Tipo de documento
research article
Resumen
Controversy persists on the association between dairy products, especially milk, and cardiovascular diseases (CVD). Genetic proxies may improve dairy intake estimations, and clarify diet-disease relationships through Mendelian randomization. We meta-analytically (n <= 20,089) evaluated associations between a lactase persistence (LP) SNP, the minichromosome maintenance complex component 6 (MCM6)-rs3754686C>T (nonpersistence>persistence), dairy intake, and CVD biomarkers in American (Hispanics, African-American and Whites) and Mediterranean populations. Moreover, we analyzed longitudinal associations with milk, CVD and mortality in PREDIMED), a randomized Mediterranean diet (MedDiet) intervention trial (n = 7185). The MCM6-rs3754686/MCM6-rs309180 (as proxy), LP-allele (T) was strongly associated with higher milk intake, but inconsistently associated with glucose and lipids, and not associated with CVD or total mortality in the whole population. Heterogeneity analyses suggested some sex-specific associations. The T-allele was associated with higher CVD and mortality risk in women but not in men (P-sex interaction: 0.005 and 0.032, respectively), mainly in the MedDiet group. However, milk intake was not associated with CVD biomarkers, CVD or mortality either generally or in sub-groups. Although MCM6-rs3754686 is a good milk intake proxy in these populations, attributing its associations with CVD and mortality in Mediterranean women to milk is unwarranted, as other factors limiting the assumption of causality in Mendelian randomization may exist.
Palabras clave
FOOD-FREQUENCY QUESTIONNAIRE | SINGLE-NUCLEOTIDE POLYMORPHISM | LACTASE-PERSISTENCE PHENOTYPE | DOSE-RESPONSE METAANALYSIS | METABOLIC RISK-FACTORS | DAIRY CONSUMPTION | UNITED-STATES | PUERTO-RICAN | BODY-WEIGHT | DIET
MESH
Cardiovascular Diseases | Aged | Genetic Markers | Minichromosome Maintenance Complex Component 6 | United States | Alleles | Humans | Mendelian Randomization Analysis | Mediterranean Region | Middle Aged | Male | Milk | Sex Factors | Female | Animals | Diet, Mediterranean
DECS
Dieta Mediterránea | Animales | Componente 6 del Complejo de Mantenimiento de Minicromosoma | Análisis de la Aleatorización Mendeliana | Leche | Femenino | Masculino | Alelos | Factores Sexuales | Humanos | Región Mediterránea | Persona de Mediana Edad | Anciano | Enfermedades Cardiovasculares | Marcadores Genéticos | Estados Unidos
Versión en línea
DOI
Aparece en las colecciones
- Investigación > IIS > IdisBa - Instituto de Investigación Sanitaria Illes Balears (Baleares)
- Investigación > IIS > IMIM - Hospital del Mar Research Institute-Barcelona (Cataluña)
- Investigación > IIS > IDIBAPS - Instituto de Investigaciones Biomédicas August Pi i Sunyer (Cataluña)
- Investigación > CNIC > Grupos de investigación
- Investigación > IIS > IdiSNA - Instituto de Investigación Sanitaria de Navarra (Navarra)
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