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dc.contributor.authorNunez, Julio
dc.contributor.authorVicente Monmeneu, Jose
dc.contributor.authorMollar, Anna
dc.contributor.authorNunez, Eduardo
dc.contributor.authorBodi, Vicent
dc.contributor.authorMinana, Gema
dc.contributor.authorGarcia-Blas, Sergio
dc.contributor.authorSantas, Enrique
dc.contributor.authorAguero, Jaume 
dc.contributor.authorChorro, Francisco J.
dc.contributor.authorSanchis, Juan
dc.contributor.authorPilar Lopez-Lereu, Maria
dc.date.accessioned2017-10-20T10:33:51Z
dc.date.available2017-10-20T10:33:51Z
dc.date.issued2016
dc.identifierISI:000387765400010
dc.identifier.citationESC Heart Fail. 2016; 3(4):293-298
dc.identifier.issn2055-5822
dc.identifier.urihttp://hdl.handle.net/20.500.12105/5173
dc.description.abstractAimsIn patients with heart failure with reduced ejection fraction (HFrEF) and iron deficiency, treatment with intravenous iron has shown a clinical improvement regardless of anaemic status. Cardiac magnetic resonance (CMR) T2{*} sequence has shown a potential utility for evaluating myocardial iron deficiency. We aimed to evaluate whether T2{*} sequence significantly changes after ferric carboximaltose (FCM) administration, and if such changes correlate with changes in left ventricle ejection fraction (LVEF). Methods and resultsIn this pilot study, we included eight patients with chronic symptomatic (New York Heart Association II-III) HFrEF and iron deficiency. A CMR, including T2{*} analysis, was performed before and at a median of 43days (interquartile range=35-48) after intravenous FCM administration. Pearson or Spearman correlation coefficient (r) was used for bivariate contrast as appropriate. A partial correlation analysis was performed between LVEF and T2{*} while controlling for anaemia status at baseline. Anaemia was present in half of patients. After FCM administration, T2{*} decreased from a median of 39.5 (35.9-48) to 32ms (32-34.5), P=0.012. Simultaneously, a borderline increase in median of LVEF [40\% (36-44.5) to 48.5\% (38.5-53), P=0.091] was registered. In a bivariate correlational analysis, T2{*} was highly correlated with LVEF (r=-0.747, P=0.033). After controlling for anaemia at baseline, the association between T2{*} and LVEF persisted [r(partial): -0.865, R-2(partial): 0.748, P=0.012]. A median regression analysis backed-up these findings. ConclusionsIn a small sample of patients with HFrEF and iron deficiency, myocardial iron repletion assessed by CMR was associated to left ventricular remodelling. Further studies are warranted.
dc.language.isoeng
dc.publisherWILEY PERIODICALS, INC
dc.relation.isversionofPublisher's version
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectIron deficiency
dc.subjectIntravenous iron
dc.subjectLeft ventricular ejection fraction
dc.subjectSystolic heart failure
dc.subjectMagnetic resonance imaging
dc.subjectT2{*} sequence
dc.subjectT2-ASTERISK-MAGNETIC RESONANCE
dc.subjectFERRIC CARBOXYMALTOSE
dc.subjectDEFICIENCY
dc.subjectANEMIA
dc.titleLeft ventricular ejection fraction recovery in patients with heart failure treated with intravenous iron: a pilot study
dc.typeArtículo
dc.rights.licenseAtribución-NoComercial 4.0 Internacional*
dc.identifier.pubmedID27867532
dc.format.volume3
dc.format.page293-298
dc.identifier.doi10.1002/ehf2.12101
dc.description.peerreviewed
dc.relation.publisherversionhttps://doi.org/10.1002/ehf2.12101
dc.identifier.journalESC Heart Failure
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovascular
dc.repisalud.institucionCNIC
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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