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dc.contributor.author | Velasco, Carlos | |
dc.contributor.author | Mateo, Jesus | |
dc.contributor.author | Santos, Arnoldo | |
dc.contributor.author | Mota-Cobian, Adriana | |
dc.contributor.author | Herranz, Fernando | |
dc.contributor.author | Pellico, Juan | |
dc.contributor.author | Mota, Ruben A. | |
dc.contributor.author | Espana, Samuel | |
dc.contributor.author | Ruiz-Cabello, Jesus | |
dc.date.accessioned | 2017-10-20T10:33:50Z | |
dc.date.available | 2017-10-20T10:33:50Z | |
dc.date.issued | 2017 | |
dc.identifier | ISI:000392550700001 | |
dc.identifier.citation | EJNMMI Res. 2017; 7(1):7 | |
dc.identifier.issn | 2191-219X | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/5167 | |
dc.description.abstract | Background: In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of Ga-68-DOTA PET for the in vivo quantitative determination of regional PBF is proposed. This methodology was implemented and tested in healthy pigs and validated using fluorescent microspheres. The study was performed on young large white pigs (n = 4). To assess the reproducibility and consistency of the method, three PET scans were obtained for each animal. Each radiotracer injection was performed simultaneously to the injection of fluorescent microspheres. PBF images were generated applying a two-compartment exchange model over the dynamic PET images. PET and microspheres values were compared by regression analysis and Bland-Altman plot. Results: The capability of the proposed technique to produce 3D regional PBF images was demonstrated. The correlation evaluation between Ga-68-DOTA PET and microspheres showed a good and significant correlation (r = 0.74, P < 0.001). Conclusions: Assessment of PBF with the proposed technique allows combining the high quantitative accuracy of PET imaging with the use of Ga-68/Ge-68 generators. Thus, Ga-68-DOTA PET emerges as a potential inexpensive method for measuring PBF in clinical settings with an extended use. | |
dc.description.sponsorship | This work was supported by a grant from the Spanish Ministry of Economy and Competitiveness (MINECO) (SAF2014-58920-R) and a grant from the Carlos III Institute of Health (FIS-FEDER PI14-01427). C. Velasco is a recipient of a fellowship from the Spanish Ministry of Education (FPU014/01794). S. Espana and A. Santos are recipients of M+Vision Advanced fellowships from the community of Madrid. The CNIC is supported by the MINECO and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). | |
dc.language.iso | eng | |
dc.publisher | Springer | |
dc.type.hasVersion | VoR | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | PET | |
dc.subject | Pulmonary blood flow | |
dc.subject | Gallium-68 | |
dc.subject | Fluorescent microspheres | |
dc.subject | POSITRON-EMISSION-TOMOGRAPHY | |
dc.subject | MYOCARDIAL-PERFUSION | |
dc.subject | LUNG PERFUSION | |
dc.subject | PIG MODEL | |
dc.subject | QUANTIFICATION | |
dc.subject | MICROSPHERES | |
dc.subject | VALIDATION | |
dc.subject | CT | |
dc.subject | DEPOSITION | |
dc.subject | VOLUME | |
dc.title | Assessment of regional pulmonary blood flow using Ga-68-DOTA PET | |
dc.type | journal article | |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 28101850 | |
dc.format.volume | 7 | |
dc.identifier.doi | 10.1186/s13550-017-0259-2 | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Ministerio de Educación, Cultura y Deporte (España) | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.contributor.funder | Fundación ProCNIC | |
dc.description.peerreviewed | Sí | |
dc.relation.publisherversion | https://doi.org/10.1186/s13550-017-0259-2 | |
dc.identifier.journal | EJNMMI Research | |
dc.repisalud.orgCNIC | CNIC::Unidades técnicas::Imagen Avanzada | |
dc.repisalud.institucion | CNIC | |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2014-58920-R | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14-01427 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/FPU014/01794 | es_ES |
dc.rights.accessRights | open access | es_ES |