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dc.contributor.author | Guerra-Espinosa, Claudia | |
dc.contributor.author | Jiménez-Fernández, María | |
dc.contributor.author | Sánchez-Madrid, Francisco | |
dc.contributor.author | Serrador, Juan M | |
dc.date.accessioned | 2024-07-09T12:58:02Z | |
dc.date.available | 2024-07-09T12:58:02Z | |
dc.date.issued | 2024-02-14 | |
dc.identifier.citation | Cells. 2024 Feb 14;13(4):339. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20362 | |
dc.description.abstract | Interactions among leukocytes and leukocytes with immune-associated auxiliary cells represent an essential feature of the immune response that requires the involvement of cell adhesion molecules (CAMs). In the immune system, CAMs include a wide range of members pertaining to different structural and functional families involved in cell development, activation, differentiation and migration. Among them, β2 integrins (LFA-1, Mac-1, p150,95 and αDβ2) are predominantly involved in homotypic and heterotypic leukocyte adhesion. β2 integrins bind to intercellular (I)CAMs, actin cytoskeleton-linked receptors belonging to immunoglobulin superfamily (IgSF)-CAMs expressed by leukocytes and vascular endothelial cells, enabling leukocyte activation and transendothelial migration. β2 integrins have long been viewed as the most important ICAMs partners, propagating intracellular signalling from β2 integrin-ICAM adhesion receptor interaction. In this review, we present previous evidence from pioneering studies and more recent findings supporting an important role for ICAMs in signal transduction. We also discuss the contribution of immune ICAMs (ICAM-1, -2, and -3) to reciprocal cell signalling and function in processes in which β2 integrins supposedly take the lead, paying particular attention to T cell activation, differentiation and migration. | es_ES |
dc.description.sponsorship | This study was supported by grant PID2022-140155OB-I00 to J.M.S. and grants PDC2021- 121719-I00 and PID-2020-120412RB-I00 to F.S.M. from the Spanish Ministry of Science, Innovation and Universities, and also supported by grants S2022/BMD-7209 (INTEGRAMUNE-CM) and by “La Caixa” Health Research Grant LCF/PR/HR23/52430018. C.G-E. was supported by Unión Europea—Next Generation EU. M.J-F. was supported by Formación Personal Investigador Severo Ochoa (FPI-SO) Program (PRE2019-087941), Ministry of Science, Innovation and Universities and Fondo Europeo de Desarrollo Regional (FEDER) and Fondo Social Europeo (FSE). The CBMSO receives an institutional grant from the Fundación Ramón Areces. The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovación (MCIN) and the Pro CNIC Foundation. The CBMSO and the CNIC are both Severo Ochoa Center of Excellence (grant CEX2021-001154-S and grant CEX2020-001041-S funded by MICIN/AEI/10.13039/501100011033). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Endothelial Cells | es_ES |
dc.subject.mesh | Cell Adhesion Molecules | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Lymphocyte Function-Associated Antigen-1 | es_ES |
dc.subject.mesh | Macrophage-1 Antigen | es_ES |
dc.subject.mesh | CD18 Antigens | es_ES |
dc.subject.mesh | Communication | es_ES |
dc.title | ICAMs in Immunity, Intercellular Adhesion and Communication. | es_ES |
dc.type | review article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 38391953 | es_ES |
dc.format.volume | 13 | es_ES |
dc.format.number | 4 | es_ES |
dc.identifier.doi | 10.3390/cells13040339 | es_ES |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | es_ES |
dc.contributor.funder | Fundación La Caixa | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2073-4409 | es_ES |
dc.relation.publisherversion | 10.3390/cells13040339 | es_ES |
dc.identifier.journal | Cells | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Comunicación Intercelular en la Respuesta Inflamatoria | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PID2022-140155OB-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PDC2021-121719-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PID-2020-120412RB-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/S2022/BMD-7209 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/LCF/PR/HR23/52430018 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PRE2019-087941 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CEX2021-001154-S | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CEX2020-001041-S | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/MICIN/AEI/10.13039/501100011033 | es_ES |