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dc.contributor.author | Fernández-Friera, Leticia | |
dc.contributor.author | García-Alvarez, Ana | |
dc.contributor.author | Oliva, Belen | |
dc.contributor.author | García-Lunar, Inés | |
dc.contributor.author | García, Iris | |
dc.contributor.author | Moreno-Arciniegas, Andrea | |
dc.contributor.author | Gómez-Talavera, Sandra | |
dc.contributor.author | Pérez-Herreras, Cristina | |
dc.contributor.author | Sánchez-González, Javier | |
dc.contributor.author | de Vega, Vicente Martinez | |
dc.contributor.author | Rossello, Xavier | |
dc.contributor.author | Bueno, Héctor | |
dc.contributor.author | Fernández-Ortiz, Antonio | |
dc.contributor.author | Ibañez, Borja | |
dc.contributor.author | Sanz, Javier | |
dc.contributor.author | Fuster, Valentín | |
dc.date.accessioned | 2024-07-09T10:50:37Z | |
dc.date.available | 2024-07-09T10:50:37Z | |
dc.date.issued | 2024-06-28 | |
dc.identifier.citation | Eur Heart J Cardiovasc Imaging. 2024 Jun 28;25(7):968-975. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20323 | |
dc.description.abstract | AIMS Evidence on the association between subclinical atherosclerosis (SA) and cardiovascular (CV) events in low-risk populations is scant. To study the association between SA burden and an ischaemic scar (IS), identified by cardiac magnetic resonance (CMR), as a surrogate of CV endpoint, in a low-risk population. METHODS AND RESULTS A cohort of 712 asymptomatic middle-aged individuals from the Progression of Early SA (PESA-CNIC-Santander) study (median age 51 years, 84% male, median SCORE2 3.37) were evaluated on enrolment and at 3-year follow-up with 2D/3D vascular ultrasound (VUS) and coronary artery calcification scoring (CACS). A cardiac magnetic study (CMR) was subsequently performed and IS defined as the presence of subendocardial or transmural late gadolinium enhancement (LGE). On CMR, 132 (19.1%) participants had positive LGE, and IS was identified in 20 (2.9%) participants. Individuals with IS had significantly higher SCORE2 at baseline and higher CACS and peripheral SA burden (number of plaques by 2DVUS and plaque volume by 3DVUS) at both SA evaluations. High CACS and peripheral SA (number of plaques) burden were independently associated with the presence of IS, after adjusting for SCORE2 [OR for 3rd tertile, 8.31; 95% confidence interval (CI) 2.85-24.2; P < 0.001; and 2.77; 95% CI, 1.02-7.51; P = 0.045, respectively] and provided significant incremental diagnostic value over SCORE2. CONCLUSION In a low-risk middle-aged population, SA burden (CAC and peripheral plaques) was independently associated with a higher prevalence of IS identified by CMR. These findings reinforce the value of SA evaluation to early implement preventive measures. CLINICAL TRIAL REGISTRATION Progression of Early Subclinical Atherosclerosis (PESA) Study Identifier: NCT01410318. | es_ES |
dc.description.sponsorship | The PESA study is co-funded equally by the Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain, and Banco Santander, Madrid, Spain. The study also receives funding from the Instituto de Salud Carlos III (ISCIII, PI15/02019) and the European Regional Development Fund (ERDF) ‘Una manera de hacer Europa’. The CNIC is supported by the ISCIII, the Ministerio de Ciencia e Innovación and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (CEX2020-001041-S). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Myocardial Infarction | es_ES |
dc.subject.mesh | Magnetic Resonance Imaging, Cine | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Risk Assessment | es_ES |
dc.subject.mesh | Cohort Studies | es_ES |
dc.subject.mesh | Atherosclerosis | es_ES |
dc.subject.mesh | Coronary Artery Disease | es_ES |
dc.subject.mesh | Asymptomatic Diseases | es_ES |
dc.subject.mesh | Prospective Studies | es_ES |
dc.subject.mesh | Adult | es_ES |
dc.title | Association between subclinical atherosclerosis burden and unrecognized myocardial infarction detected by cardiac magnetic resonance in middle-aged low-risk adults. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 38426763 | es_ES |
dc.format.volume | 25 | es_ES |
dc.format.number | 7 | es_ES |
dc.format.page | 968 | es_ES |
dc.identifier.doi | 10.1093/ehjci/jeae044 | es_ES |
dc.contributor.funder | Centro Nacional de Investigaciones Cardiovasculares Carlos III (España) | es_ES |
dc.contributor.funder | Banco Santander | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2047-2412 | es_ES |
dc.relation.publisherversion | 10.1093/ehjci/jeae044 | es_ES |
dc.identifier.journal | European heart journal. Cardiovascular Imaging | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionales | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI15/02019 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CEX2020-001041-S | es_ES |