dc.contributor.author | Izzi, Benedetta | |
dc.contributor.author | Fuster, Jose J. | |
dc.date.accessioned | 2024-07-08T14:53:36Z | |
dc.date.available | 2024-07-08T14:53:36Z | |
dc.date.issued | 2024-02 | |
dc.identifier.citation | Hamostaseologie. 2024 Feb;44(1):13-20. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20214 | |
dc.description.abstract | Acquired mutations that lead to clonal hematopoiesis have emerged as a new and potent risk factor for atherosclerotic cardiovascular disease and other cardiovascular conditions. Human sequencing studies and experiments in mouse models provide compelling evidence supporting that this condition, particularly when driven by specific mutated genes, contributes to the development of atherosclerosis by exacerbating inflammatory responses. The insights gained from these studies are paving the way for the development of new personalized preventive care strategies against cardiovascular disease. Furthermore, available evidence also suggests a potential relevance of these mutation in the context of thrombosis, an area requiring thorough investigation. In this review, we provide an overview of our current understanding of this emerging cardiovascular risk factor, focusing on its relationship to atherosclerosis and thrombosis. | es_ES |
dc.description.sponsorship | Research work in our laboratory related to this topic is
supported by grant PLEC2021-008194, funded by
MCIN/AEI/10.13039/501100011033 and by the “European
Union NextGenerationEU/PRTR”; by grant PID2021-1265
80OB-I00, funded by MCIN/AEI/10.13039/501100011033
and by “ERDF A way of making Europe”; and by the “la
Caixa” Foundation (ID 100010434) under agreement
LCF/PR/HR22/00732. BI is supported by the program
Atracción de Talento of the Comunidad de Madrid (GN:
2022-T1/BMD-23767). The CNIC is supported by the MICIN,
the Instituto de Salud Carlos III, the Pro-CNIC Foundation,
and is a Severo Ochoa Center of Excellence (grant number
CEX2020-001041-S). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | GEORG THIEME VERLAG KG | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Cardiovascular Diseases | es_ES |
dc.subject.mesh | Atherosclerosis | es_ES |
dc.subject.mesh | Thrombosis | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Mice | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Risk Factors | es_ES |
dc.subject.mesh | Clonal Hematopoiesis | es_ES |
dc.subject.mesh | Hematopoiesis | es_ES |
dc.subject.mesh | Heart Disease Risk Factors | es_ES |
dc.subject.mesh | Mutation | es_ES |
dc.title | Clonal Hematopoiesis and Cardiovascular Risk: Atherosclerosis, Thrombosis, and beyond. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 38417801 | es_ES |
dc.format.volume | 44 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 13 | es_ES |
dc.identifier.doi | 10.1055/a-2219-6410 | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. NextGenerationEU | es_ES |
dc.contributor.funder | Fundación La Caixa | es_ES |
dc.contributor.funder | Comunidad de Madrid (España) | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2567-5761 | es_ES |
dc.relation.publisherversion | 10.1055/a-2219-6410 | es_ES |
dc.identifier.journal | Hamostaseologie | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Fisiopatología Hematovascular | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PLEC2021-008194 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/MCIN/AEI/10.13039/501100011033 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PID2021-126580OB-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/LCF/PR/HR22/00732/100010434 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/2022-T1/BMD-23767 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CEX2020-001041-S | es_ES |