dc.contributor.author | Polo-Generelo, Salvador | |
dc.contributor.author | Rodríguez-Mateo, Cristina | |
dc.contributor.author | Torres, Belén | |
dc.contributor.author | Pintor-Tortolero, José | |
dc.contributor.author | Guerrero-Martínez, José A | |
dc.contributor.author | König, Julian | |
dc.contributor.author | Vazquez, Jesus | |
dc.contributor.author | Bonzón-Kulichenco, Elena | |
dc.contributor.author | Padillo-Ruiz, Javier | |
dc.contributor.author | de la Portilla, Fernando | |
dc.contributor.author | Reyes, José C | |
dc.contributor.author | Pintor-Toro, José A | |
dc.date.accessioned | 2024-07-08T14:39:26Z | |
dc.date.available | 2024-07-08T14:39:26Z | |
dc.date.issued | 2024-03-06 | |
dc.identifier.citation | Cell Death Discov. 2024 Mar 6;10(1):116. | es_ES |
dc.identifier.issn | 2058-7716 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20213 | |
dc.description.abstract | Serine protease inhibitor clade E member 1 (SERPINE1) inhibits extracellular matrix proteolysis and cell detachment. However, SERPINE1 expression also promotes tumor progression and plays a crucial role in metastasis. Here, we solve this apparent paradox and report that Serpine1 mRNA per se, independent of its protein-coding function, confers mesenchymal properties to the cell, promoting migration, invasiveness, and resistance to anoikis and increasing glycolytic activity by sequestering miRNAs. Expression of Serpine1 mRNA upregulates the expression of the TRA2B splicing factor without affecting its mRNA levels. Through transcriptional profiling, we found that Serpine1 mRNA expression downregulates through TRA2B the expression of genes involved in the immune response. Analysis of human colon tumor samples showed an inverse correlation between SERPINE1 mRNA expression and CD8+ T cell infiltration, unveiling the potential value of SERPINE1 mRNA as a promising therapeutic target for colon tumors. | es_ES |
dc.description.sponsorship | We wish to thank Dr. Olga Anczuków for providing the pWZL-Hygro-Tra2b plasmid.
We are grateful to Dr. Abelardo López-Rivas and Dr. Laura Martínez-Muñoz for critical
reading of the manuscript, and Dr. Mario Domínguez for technical support. This work
was supported by grants from Ministerio de Ciencia e Innovación: PID2020-
119732RB-I00 to JAP-T and PID2020-118516GB-I00 to JCR. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Serpine1 mRNA confers mesenchymal characteristics to the cell and promotes CD8+ T cells exclusion from colon adenocarcinomas. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 38448406 | es_ES |
dc.format.volume | 10 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 116 | es_ES |
dc.identifier.doi | 10.1038/s41420-024-01886-8 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | 10.1038/s41420-024-01886-8 | es_ES |
dc.identifier.journal | Cell death discovery | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Proteómica cardiovascular | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PID2020-119732RB-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PID2020-118516GB-I00 | es_ES |