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dc.contributor.author | Curtabbi, Andrea | |
dc.contributor.author | Enriquez, Jose Antonio | |
dc.date.accessioned | 2024-07-08T10:30:15Z | |
dc.date.available | 2024-07-08T10:30:15Z | |
dc.date.issued | 2022-07 | |
dc.identifier.citation | IUBMB Life. 2022 Jul;74(7):629-644. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20198 | |
dc.description.abstract | The flavin mononucleotide (FMN) cofactor of respiratory complex I occupies a key position in the electron transport chain. Here, the electrons coming from NADH start the sequence of oxidoreduction reactions, which drives the generation of the proton-motive force necessary for ATP synthesis. The overall architecture and the general catalytic proprieties of the FMN site are mostly well established. However, several aspects regarding the complex I flavin cofactor are still unknown. For example, the flavin binding to the N-module, the NADH-oxidizing portion of complex I, lacks a molecular description. The dissociation of FMN from the enzyme is beginning to emerge as an important regulatory mechanism of complex I activity and ROS production. Finally, how mitochondria import and metabolize FMN is still uncertain. This review summarizes the current knowledge on complex I flavin cofactor and discusses the open questions for future research. | es_ES |
dc.description.sponsorship | This work was supported by the following researchgrants: RTI2018-099357-B-I00, HFSP (RGP0016/2018) CIBERFES16/10/00282 and RED2018-102576-T, Leducq2016 (17CVD04). This project has received funding fromthe European Union's Horizon 2020 research and inno-vation programme under the Marie Skłodowska-Curiegrant agreement No. 713673.” The CNIC is supportedby the Pro-CNIC Foundation and is a SeveroOchoa Center of Excellence. Figures are created with BioRender.com. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.type.hasVersion | CVoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Electron Transport Complex I | es_ES |
dc.subject.mesh | Flavin Mononucleotide | es_ES |
dc.subject.mesh | Flavins | es_ES |
dc.subject.mesh | NAD | es_ES |
dc.subject.mesh | Oxidation-Reduction | es_ES |
dc.title | The ins and outs of the flavin mononucleotide cofactor of respiratory complex I. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 35166025 | es_ES |
dc.format.volume | 74 | es_ES |
dc.format.number | 7 | es_ES |
dc.format.page | 629 | es_ES |
dc.identifier.doi | 10.1002/iub.2600 | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. H2020 | es_ES |
dc.contributor.funder | Marie Curie | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1521-6551 | es_ES |
dc.relation.publisherversion | 10.1002/iub.2600 | es_ES |
dc.identifier.journal | IUBMB life | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Genética Funcional del Sistema de Fosforilación Oxidativa | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/713673 | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RTI2018-099357-B-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RGP0016/2018 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CIBERFES16/10/00282 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RED2018-102576-T | es_ES |