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dc.contributor.author | Zeng, Qun | |
dc.contributor.author | Oliva, Valeria Maria | |
dc.contributor.author | Moro, María Ángeles | |
dc.contributor.author | Scheiermann, Christoph | |
dc.date.accessioned | 2024-07-04T13:05:56Z | |
dc.date.available | 2024-07-04T13:05:56Z | |
dc.date.issued | 2024-03-15 | |
dc.identifier.citation | Circ Res. 2024 Mar 15;134(6):791-809. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20181 | |
dc.description.abstract | Circadian rhythms exert a profound impact on most aspects of mammalian physiology, including the immune and cardiovascular systems. Leukocytes engage in time-of-day-dependent interactions with the vasculature, facilitating the emigration to and the immune surveillance of tissues. This review provides an overview of circadian control of immune-vascular interactions in both the steady state and cardiovascular diseases such as atherosclerosis and infarction. Circadian rhythms impact both the immune and vascular facets of these interactions, primarily through the regulation of chemoattractant and adhesion molecules on immune and endothelial cells. Misaligned light conditions disrupt this rhythm, generally exacerbating atherosclerosis and infarction. In cardiovascular diseases, distinct circadian clock genes, while functioning as part of an integrated circadian system, can have proinflammatory or anti-inflammatory effects on these immune-vascular interactions. Here, we discuss the mechanisms and relevance of circadian rhythms in vascular immunopathologies. | es_ES |
dc.description.sponsorship | The work in the Scheiermann Laboratory was supported by grants from the European Research Council (CoG 101001233 and CIRCADYN to C. Scheiermann), the Swiss National Science Foundation (310030_219256/1 to C. Scheiermann), the Swiss Cancer League (KLS-4836-08-2019 to C. Scheiermann), and the Geneva Cancer League (2106 to C. Scheiermann). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Lippincott Williams & Wilkins (LWW) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Atherosclerosis | es_ES |
dc.subject.mesh | Cardiovascular Diseases | es_ES |
dc.subject.mesh | Circadian Clocks | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Circadian Rhythm | es_ES |
dc.subject.mesh | Endothelial Cells | es_ES |
dc.subject.mesh | Infarction | es_ES |
dc.subject.mesh | Mammals | es_ES |
dc.title | Circadian Effects on Vascular Immunopathologies. | es_ES |
dc.type | review article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 38484032 | es_ES |
dc.format.volume | 134 | es_ES |
dc.format.number | 6 | es_ES |
dc.format.page | 791 | es_ES |
dc.identifier.doi | 10.1161/CIRCRESAHA.123.323619 | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | es_ES |
dc.contributor.funder | Swiss National Science Foundation | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1524-4571 | es_ES |
dc.identifier.journal | Circulation research | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Fisiopatología Neurovascular | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/ERC/CoG/101001233 | es_ES |
dc.rights.accessRights | open access | es_ES |