dc.contributor.author | Nieto-Roca, Luis | |
dc.contributor.author | Camblor Blasco, Andrea | |
dc.contributor.author | Devesa, Ana | |
dc.contributor.author | Gómez-Talavera, Sandra | |
dc.contributor.author | Balaguer-Germán, Jorge | |
dc.contributor.author | Lumpuy-Castillo, Jairo | |
dc.contributor.author | Pello, Ana María | |
dc.contributor.author | Dhier, Luis Martínez | |
dc.contributor.author | Lapeña, Gregoria | |
dc.contributor.author | Jiménez, Lucía Llanos | |
dc.contributor.author | Lorenzo, Óscar | |
dc.contributor.author | Tuñón, José | |
dc.contributor.author | Ibáñez, Borja | |
dc.contributor.author | Aceña, Álvaro | |
dc.date.accessioned | 2024-07-03T13:08:34Z | |
dc.date.available | 2024-07-03T13:08:34Z | |
dc.date.issued | 2024-04-30 | |
dc.identifier.citation | J Cardiovasc Dev Dis. 2024 Apr 30;11(5):142. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20031 | |
dc.description.abstract | BACKGROUND
Transthyretin cardiac amyloidosis (ATTR amyloidosis) is a frequent etiology of heart failure. Inflammation and mineral metabolism are associated with myocardial dysfunction and clinical performance. Cardiac global longitudinal strain (GLS) allows function assessment and is associated with prognosis. Our aim was to describe possible correlations between GLS, biomarker levels and clinical performance in ATTR amyloidosis.
METHODS
Thirteen patients with ATTR amyloidosis were included. Clinical characteristics; echocardiographic features, including strain assessment and 6 min walk test (6MWT); and baseline inflammatory, mineral metabolism and cardiovascular biomarker levels were assessed.
RESULTS
Of the 13 patients, 46.2% were women, and the mean age was 79 years. TAPSE correlated with NT-ProBNP (r -0.65, p < 0.05) and galectin-3 (r 0.76, p < 0.05); E/E' ratio correlated with hsCRP (r 0.58, p < 0.05). Left ventricular GLS was associated with NT-ProBNP (r 0.61, p < 0.05) (patients have a better prognosis if the strain value is more negative) and left atrial GLS with NT-ProBNP (r -0.73, p < 0.05) and MCP1 (r 0.55, p < 0.05). Right ventricular GLS was correlated with hsTnI (r 0.62, p < 0.05) and IL6 (r 0.881, p < 0.05). Klotho levels were correlated with 6MWT (r 0.57, p < 0.05).
CONCLUSIONS
While inflammatory biomarkers were correlated with cardiac function, klotho levels were associated with clinical performance in the population with TTR-CA. | es_ES |
dc.description.sponsorship | This study received funding from the Instituto de Salud Carlos III (ISCIII; PI19/00655
and PI20/0923), with cofunding from the European Regional Development Fund (ERDF) ‘A way
of making Europe’ (Á.A.) and the Ministry of Science and Innovation (RTC2019-006826-1). B.I. is
funded by the European Research Council (ERC) under the European Union Horizon 2020 Research
and Innovation Program (ERC-Consolidator grant agreement no. 819775) and by the Ministry of
Science and Innovation (‘RETOS 2019′ grant no. PID2019-107332RB-I00). The CNIC is supported
by the ISCIII, the MCN and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence
(SEV-2015-0505). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Serum Biomarkers and Their Association with Myocardial Function and Exercise Capacity in Cardiac Transthyretin Amyloidosis. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 38786964 | es_ES |
dc.format.volume | 11 | es_ES |
dc.format.number | 5 | es_ES |
dc.identifier.doi | 10.3390/jcdd11050142 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2308-3425 | es_ES |
dc.relation.publisherversion | 10.3390/jcdd11050142 | es_ES |
dc.identifier.journal | Journal of cardiovascular development and disease | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovascular | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/ERC/CoG/819775 | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI19/00655 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI20/0923 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RTC2019-006826-1 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PID2019-107332RB-I00 | es_ES |